4-Hydroxy-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

4-Hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile is often involved in the field of pharmaceutical chemistry in various uses.
In the process of pharmaceutical research and development, it can be a key intermediate. The molecular structure is unique and can participate in the reaction in a specific way, resulting in the construction of more complex and biologically active compounds. For example, when creating new antimalarial drugs, chemists may integrate them into drug molecules through ingenious synthetic pathways. Functional groups such as hydroxyl and formonitrile in its structure can interact with specific targets in the malaria parasite, or interfere with the metabolic process of the malaria parasite, or hinder its protein synthesis, thus achieving anti-malarial effect.
In the context of materials science, its structure endows specific physical and chemical properties, or can be used to prepare functional materials. For example, if it is introduced into a polymer material system, its unique structure may improve the thermal stability and optical properties of the material. The interaction mode between its molecules can promote the formation of a specific microstructure of the material, which in turn exhibits characteristics that are completely different from conventional materials, paving the way for the development of new materials.
In the field of organic synthetic chemistry, it is often used as a key building block. Based on its structure, chemists use various organic reactions, such as nucleophilic substitution, cyclization, etc., to derive a series of compounds with novel structures. In this process, it is like the cornerstone of building a complex molecular edifice. It is cleverly spliced by organic synthesis to construct a variety of organic molecules with potential application value, which promotes organic synthetic chemistry and opens up new molecular spaces and application fields.

The method for synthesizing 4-hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile can be carried out according to the following steps.
First take a suitable starting material, or a material with a pyrazolo [1,5-a] pyridine skeleton, and there are chemically convertible groups on it, such as halogen atoms, hydroxyl groups, etc. This is the basis for the reaction.
6- (2-hydroxy-2-methylpropoxy) structure is constructed by etherification reaction. Hydroxy-containing pyrazolo [1,5-a] pyridine and 2-halo-2-methylpropanol can be heated and stirred in suitable solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) in the presence of bases such as potassium carbonate and sodium carbonate to promote the formation of ether bonds. In this reaction, the base can capture the hydrogen of the phenolic hydroxyl group to form phenoxy anions, which enhances its nucleophilicity and is conducive to the nucleophilic substitution reaction with halogenated hydrocarbons to generate the desired ether structure.
For the introduction of 4-hydroxy groups, if the corresponding position in the starting material is a halogen atom, the nucleophilic substitution reaction can be carried out. If a phenate salt or an alcohol salt is reacted with a pyridine derivative containing a halogen atom, the halogen atom is replaced by a hydroxyl group for the purpose of introducing a 4-hydroxyl group. The reaction conditions need to consider the temperature, solvent and the proportion of the reactants. For example, by reacting an aqueous sodium hydroxide solution with a halogen-containing substrate at an appropriate temperature, the hydroxyl group can be substituted for the halogen atom.
And the introduction of the 3-formonitrile group can be used for cyanidation. If the starting material is a halogen atom in this position, it can react with cyanide reagents such as potassium cyanide, sodium cyanide, etc., in an organic solvent in the presence of a phase transfer catalyst such as tetrabutylammonium bromide. The phase transfer catalyst can promote the ionic cyanide reagent to enter the organic phase, accelerate the cyanide reaction, and replace the halogen atom with a cyanyl group to form a 3-formonitrile group.
After each step of the reaction, it needs to be separated and purified by methods such as column chromatography, recrystallization, etc., to obtain high-purity 4-hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile products. The whole synthesis process needs to pay attention to the control of reaction conditions to achieve good yield and purity.

The physicochemical properties of 4-hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile are as follows.
From the perspective of this compound, it is often in a solid state, mostly in the form of white or off-white powders. The powder is fine in texture and has a relatively uniform touch. The lid is arranged in an orderly manner due to its molecular structure, resulting in its appearance.
Its melting point is crucial for identification and purification. After many experiments, the melting point of this substance is in a specific range, which is derived from the size and characteristics of intermolecular forces. Intermolecular interactions, such as hydrogen bonds, van der Waals forces, etc., jointly maintain the arrangement of molecules. When heated to the melting point, these forces are weakened, and the orderly arrangement of molecules is destroyed, so it changes from solid to liquid.
Solubility is also an important physical and chemical property. In common organic solvents, its solubility varies. In polar organic solvents, such as ethanol and dimethyl sulfoxide, there is a certain solubility. This is because polar solvents interact with the polar groups of the compound, which can effectively disperse compound molecules. In non-polar solvents, such as n-hexane and benzene, the solubility is very small, and the force between the polar part of its molecular structure and the non-polar solvent is weak. In terms of stability,
is relatively stable under normal temperature and pressure without the interference of special chemical environment. However, in case of strong acid, strong base or high temperature environment, the molecular structure may change. Because strong acid and strong base can chemically react with specific groups of compounds, high temperature intensifies molecular movement, making chemical bonds easier to break and rearrange.
Spectral characteristics also have characteristics. In the infrared spectrum, specific functional groups have corresponding absorption peaks. For example, the absorption peak of hydroxyl groups can indicate the existence of hydroxyl groups, and the absorption peak of nitrile groups can confirm the structure of nitrile groups. This spectral characteristic provides a strong basis for its qualitative and quantitative analysis.

I don't know what the market price of 4 - Hydroxy - 6 - (2 - hydroxy - 2 - methylpropoxy) pyrazolo [1,5 - a] pyridine - 3 - carbonitrile is. This compound may not be widely known and commonly used, and it is circulating or rare in the market, so its price is difficult to determine.
Guanfu's "Tiangong Kaiwu", there are many records of craftsmanship and the origin of products. It is related to the price of various things, or it is slightly involved, but it is all related to the genus of materials and various utensils commonly used in people's livelihood. Such fine chemical synthesis compounds are not recorded in the book.
If you want to know the price of this product today, you need to explore the chemical raw material market and chemical reagent suppliers. However, its price is also affected by many factors, such as the difficulty of synthesis, the price of raw materials required, the amount of market demand, and the difference between manufacturers. Or the price is high due to the complex synthesis process and the rarity of raw materials, or the price is low due to the lack of market demand. And different suppliers have different prices, and wholesale and retail prices are also different. To get the exact number, you need to consult the merchant in detail to know the general outline.

4-Hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile has a wide range of application fields. In the field of pharmaceutical research and development, this compound may have unique biological activities and can be used as a potential drug precursor. The structure of Geinpyrazolo-pyridine often shows various biological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. The presence of hydroxyl and alkoxy groups in its molecules may change the lipophilicity and hydrophilicity of the compound, thereby affecting its ability to bind to biological targets. In this field, researchers can explore its structure-activity relationship and develop specific new drugs to solve the suffering of patients.
In agricultural chemistry, such compounds may have the functions of insecticidal, bactericidal or plant growth regulation. Because they contain specific functional groups such as cyanide groups, they may interfere with the physiological processes of pests and achieve insecticidal effects; or they can regulate plant metabolism, promote crop growth, and improve the quality and quantity of agricultural products. This is of great significance in ensuring agricultural harvest and maintaining ecological balance.
Furthermore, in the field of materials science, 4-hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile or can be used as a construction unit of special functional materials. Because of its stable structure and reactive activity check point, or can be chemically modified, materials with specific optical, electrical or adsorption properties can be prepared to meet different industrial needs, such as electronic devices, adsorption separation and other fields.
In summary, 4-hydroxy-6- (2-hydroxy-2-methylpropoxy) pyrazolo [1,5-a] pyridine-3-formonitrile has potential applications in the fields of medicine, agriculture and materials science. It needs to be further explored by researchers to develop its greater value.