4-Cyano-2-fluoropyridine

4-Cyano-2-fluoropyridine is one of the valuable organic compounds. Its main application fields are wide, and its contribution is particularly significant in the field of medicinal chemistry. Because of its unique structure, good biological activity and drug affinity, it is often a key intermediate for the synthesis of new drugs. When doctors develop antibacterial, antiviral and anti-cancer drugs, they often rely on this compound as the basis and are chemically modified to become specific drugs.
In the field of materials science, 4-cyano-2-fluoropyridine also plays an important role. It can participate in the preparation of special functional materials, such as optoelectronic materials. The materials constructed from it may have excellent optical and electrical properties, and can be applied to high-tech industries such as organic Light Emitting Diode (OLED) and solar cells to enhance the performance of such materials.
Furthermore, in the field of pesticide chemistry, this compound also has a place. With its special chemical properties, it can be used as a raw material for the synthesis of high-efficiency and low-toxicity pesticides. The pesticides produced have strong lethality to specific pests and are less harmful to the environment, which meets the needs of the current development of green agriculture, and contributes to ensuring the harvest of crops and maintaining ecological balance. Overall, 4-cyano-2-fluoropyridine has key applications in various fields such as medicine, materials, and pesticides, promoting the progress and development of various industries.

The synthesis method of 4-cyano-2-fluoropyridine has been explored by many sages in the past. The following are the common ones.
First, 2-fluoropyridine is used as the starting material and prepared by cyanidation. In the reactor, put 2-fluoropyridine and dissolve it in a suitable organic solvent, such as dichloromethane. Cool down to a specific temperature, such as about 0 ° C, and slowly add a cyanide reagent, commonly known as cuprous cyanide. This process requires close monitoring of the reaction process. Due to the toxicity of cuprous cyanide, the operation must be cautious. After adding, heat up to an appropriate temperature, such as 50 ° C, and stir the reaction for several times. After the reaction is completed, 4-cyano-2-fluoropyridine can be obtained through extraction, washing, drying, distillation and other purification steps.
Second, start from 2-fluoro-4-halopyridine. First select 2-fluoro-4-chloropyridine or 2-fluoro-4-bromopyridine and react it with a cyanide reagent. Potassium cyanide can be selected and carried out in a polar solvent such as N, N-dimethylformamide (DMF). The reaction temperature is about 100 ° C. In an alkaline environment, such as adding potassium carbonate to assist the reaction. In the reaction, the halogen atom is replaced by a cyanyl group to form the target product. Subsequent purification is carried out by reduced pressure distillation, column chromatography and other methods.
Third, the coupling reaction catalyzed by palladium. React with 2-fluoropyridine boronic acid or its derivatives with cyanylation reagents, such as cyanotrimethylsilane, under the action of palladium catalysts, such as tetra (triphenylphosphine) palladium. In an organic solvent toluene, add an appropriate amount of base, such as cesium carbonate, and heat to about 80 ° C. This method has mild conditions and good selectivity, but the cost of palladium catalysts is higher.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, cost, reaction conditions and product purity to choose the most suitable method.

4-Cyano-2-fluoropyridine, in today's market, its price is geometric, and it is difficult to judge. Given its price, it is determined by various factors, just like the trade-off of ancient times, and it needs to be considered in many ways before it can be determined.
First, it is related to the technique of production. If the preparation method is simple and efficient, the raw materials are convenient to use, the cost can be reduced, and the price is also easier. If the ancient craftsmanship makes good use of clever technology, saves labor and is effective, the value of the product is also appropriate. However, if the preparation is complicated, the conditions are strict, rare raw materials are required, or huge amounts of resources are consumed, the cost will be high, and the price will also rise, just like the fine-crafted jade, the price is high and rare.
Second, the supply and demand of the market is the cardinal of the price. If there are many people who want it, but there are few people who supply it, if there are frequent wars, military supplies need it, or pharmaceutical research and development, chemical production and other industries rely on it increasingly, but the production capacity is not enough, the price will rise, just like the grain in a dry year, although expensive and people compete to buy it. On the contrary, if the supply exceeds the demand, manufacturers compete to ship, and the price will fall automatically, just like the valley of a good year, although there are many but worthless.
Third, changes in the current situation also affect its price. Regulations on international commerce and trade, increases and decreases in tariffs, and obstacles to transportation are all important factors. If trade barriers are high, tariffs rise sharply, or accidents occur during transportation, such as rivers and rivers are congested and boats are difficult to navigate, the cost will increase and the price will also rise.
According to past market conditions, the price may fluctuate between hundreds and thousands of yuan per kilogram. However, this is only a rough number, and times change. Today's price should be subject to real-time market news. If you want to know the exact price, you can consult the supplier of chemical raw materials or visit a professional chemical trading platform to obtain the current actual price, just like asking someone who is familiar with the path, you can reach the place you want.

4-Cyano-2-fluoropyridine, this is an organic compound with unique physical and chemical properties.
In terms of its physical properties, 4-cyano-2-fluoropyridine is mostly colorless to light yellow liquid at room temperature and pressure, and it looks clear. Its boiling point is about 220-225 ° C, which makes it change from liquid to gaseous at a specific temperature environment. The melting point is around -20 ° C, which means that when the temperature drops to this value, the compound solidifies from liquid to solid. Its density is about 1.25 g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom of the water. The compound has little solubility in water, but it can be soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. Due to the principle of "similar miscibility", its molecular structure is similar to that of organic solvents, so it can be miscible.
As for chemical properties, the cyano group (-CN) of 4-cyano-2-fluoropyridine and the fluorine atom (-F) give it unique reactivity. Cyanyl groups have high reactivity and can participate in many reactions, such as hydrolysis reactions. Under the catalysis of acids or bases, cyanyl groups can be gradually converted into carboxyl groups (-COOH) to form 4-carboxyl-2-fluoropyridine; they can also participate in nucleophilic addition reactions, like reacting with alcohols under specific conditions to form nitrogen-containing heterocyclic derivatives. Fluorine atoms change the electron cloud density of the pyridine ring due to their high electronegativity, which affects the activity of electrophilic substitution reactions. Electrophilic substitution reactions on pyridine rings usually occur at higher electron cloud densities, while the electron cloud densities of the adjacent and para-sites of fluorine atoms are relatively reduced, and the meta-sites are relatively high. Therefore, electrophilic substitution reactions are more likely to occur at the At the same time, 4-cyano-2-fluoropyridine can be used as a ligand to complex with metal ions to form metal complexes, which has potential applications in the field of catalysis. Due to its unique physical and chemical properties, 4-cyano-2-fluoropyridine is widely used in medicine, pesticides, materials science and other fields.

4-Cyano-2-fluoropyridine is an important intermediate in organic synthesis, and many matters need to be paid attention to during storage and transportation.
First, storage, this material prefers a dry and cool place, and shelter from heat and fire sources is the most important. Because it is easy to decompose when heated, it causes changes in properties, loses its original effectiveness and endangers safety. Therefore, it must be stored in a well-ventilated warehouse, away from fire and heat sources. The storage temperature should be controlled within a suitable range, and must not be too high. In addition, this product has certain toxicity and irritation, and must be stored separately from oxidants, acids, bases, etc., to prevent dangerous interactions. When storing, you should also pay attention to the integrity of the package. If the package is damaged, it is very easy to leak and cause harm.
As for transportation, transportation personnel must be familiar with its characteristics and emergency treatment methods. Vehicles used in transportation must be clean, dry, and free of any residues that react to it. During transportation, the vehicle should be kept steady to avoid severe vibration and impact to prevent damage to the package. And when transporting, proper protective measures should be taken, such as emergency treatment equipment for leaks. If the transportation process encounters high temperature weather, it is advisable to take necessary cooling measures to ensure that the temperature is appropriate. At the same time, the packaging of transportation must be in accordance with relevant regulations, affixed with obvious warning signs to make others aware of its danger.
Therefore, during the storage and transportation of 4-cyano-2-fluoropyridine, attention should be paid to the above in order to ensure its safety and avoid accidents.