4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID AMIDE

4-Chloropyridine-2-carboxylic acid amide, an organic compound, has a wide range of uses. In the field of medicine, it is often used as a key intermediate to create a variety of drugs. For example, in the synthesis of some antibacterial drugs, this compound may be an indispensable raw material. With its unique chemical structure, it helps to build the active part of the drug, inhibits or kills bacteria, and escorts human health.
In the field of pesticides, it also plays an important role. It can be used as a basic material for the synthesis of new pesticides, targeting specific crop diseases and insect pests to develop pesticide products with high efficiency and low toxicity. In this way, it can not only effectively protect crops from pests and diseases, ensure food yield and quality, but also reduce the negative impact on the environment, which is in line with the current needs of green agriculture development.
In the field of materials science, 4-chloropyridine-2-carboxylic acid amide also shows potential value. Or it can be used to prepare polymer materials with special properties, which can be introduced into polymer structures through chemical reactions to give materials such as better stability, solubility or functionality, and expand the application range of materials to meet the requirements of different industries for special properties of materials.
In conclusion, 4-chloropyridine-2-carboxylic acid amides have important uses in many fields such as medicine, pesticides and materials science. With the continuous advancement of science and technology, their application prospects may be broader.

4-Chloro-pyridine-2-carboxylic acid amide, this substance is white to off-white crystalline powder, pure in appearance, with little variegation. Its smell is very small, and you can feel a faint fragrance when you smell it. The melting point is quite specific, about 182-184 ° C. At this temperature, it gradually melts from a solid state to a liquid state, and this transition process is smooth and orderly.
Its solubility also has characteristics. In common organic solvents, such as methanol and ethanol, it can dissolve to a certain extent, like snowflakes merging into spring water, quietly disappearing, forming a uniform solution; however, in water, the solubility is relatively limited, and it can only be slightly dissolved, just like sand and gravel entering water, making it difficult to form a whole. < Br >
In terms of stability, under normal environmental conditions, if it is placed in a dry, cool and free of strong light, it can maintain its own chemical structure for a long time and is not easy to deteriorate. However, in the environment of strong acid and alkali, it is like a weak body facing a violent storm, and its molecular structure is easily damaged, triggering a chemical reaction and generating other substances.
As for its performance in chemical reactions, it has unique reactivity due to the arrangement of specific atoms and chemical bonds in its molecules. Under suitable reaction conditions, it can react with many reagents, such as substitution and addition, just like a delicate craftsman, according to different instructions, shaping different forms of chemical products, which are widely used in the field of organic synthesis and are often the key raw materials for the construction of complex organic molecules in the hands of chemists.

4-Chloro-pyridine-2-carboxylic acid amide, this is an organic compound. The stability of its chemical properties is related to many factors.
Looking at its structure, the pyridine ring has a certain aromatic stability, but the presence of chlorine atoms and amide groups has an important impact on its properties. The strong electron absorption of chlorine atoms will reduce the electron cloud density of the pyridine ring and reduce the electrophilic substitution activity on the ring. However, in the nucleophilic substitution reaction, the chlorine atom can be used as a leaving group to endow the molecule with a certain reactivity.
In the amide group, the nitrogen atom is connected to the carbonyl group, and there is a conjugation effect, which makes the amide bond relatively stable. However, under certain conditions, such as in a strong acid or alkali environment, amide bonds can undergo hydrolysis reactions. In acidic media, protons will combine with carbonyl oxygen to enhance the positive electrical properties of carbonyl carbons, and water molecules attack carbonyl carbons. After a series of steps, amide bonds are broken to form carboxylic acids and ammonium salts; in alkaline media, hydroxide ions attack carbonyl carbons, eventually producing carboxylic salts and ammonia.
From the perspective of stability, 4-chloro-pyridine-2-carboxylic acid amides can remain relatively stable in normal temperature, neutral and dry environments. However, under extreme conditions such as high temperature, high humidity or strong acid and alkali, the chemical stability is challenged, and the above-mentioned hydrolysis and other reactions are prone to occur, resulting in changes in molecular structure.
In summary, the chemical stability of 4-chloro-pyridine-2-carboxylic acid amides is not absolute, and varies with external conditions. It is more stable under mild conditions, and is easy to react under extreme conditions.

The preparation method of 4-chloro-pyridine-2-carboxylic acid amide is based on the number-following method in the past.
First, 4-chloro-pyridine-2-carboxylic acid is used as the starting material. First, the acid is heated with thionyl chloride, and the carboxyl group in the acid can be converted into an acid chloride, which has high activity. Next, the generated acid chloride is mixed with ammonia or an alcohol solution of ammonia. The acid chloride and ammonia undergo nucleophilic substitution reaction, and the chlorine atom is replaced by an amino group, so 4-chloro-pyridine-2-carboxylic acid amide is obtained. Although this way is more direct, the sulfinyl chloride is corrosive, and the operation must be cautious, and the control of reaction conditions is also critical. Temperature and time all affect the yield and purity.
Second, start from 4-chloro-2-cyanopyridine. Put it in a suitable solvent, such as alcohol, and add an appropriate amount of acid or base as a catalyst to hydrolyze it. The cyanyl group is hydrolyzed to form a carboxyl group first. If ammonia or ammonium salt is in the reaction system during hydrolysis, the carboxyl group interacts with ammonia to form 4-chloro-pyridine-2-carboxylic acid amide in one step. The choice of hydrolysis conditions is severe, too strong acid and base, and too high temperature can cause side reactions to produce and damage the quality of the product.
Third, pyridine is used as the parent nucleus. The desired substituent is introduced first at the 2nd and 4th positions of the pyridine ring. For example, pyridine is halogenated with an appropriate halogenating agent to obtain 4-chloropyridine, and then carboxyl derivatives are introduced at the 2nd position through a series of reactions. Finally, 4-chloro-pyridine-2-carboxylic acid amide is obtained by amidation. There are many steps in this path, but each step can be flexibly adjusted according to the convenience of raw materials and the characteristics of the reaction, which is beneficial to the precise control of the product structure. However, the overall process is complicated, and each step of separation and purification also requires fine operation.
All kinds of production methods have advantages and disadvantages. In actual preparation, when considering the availability of raw materials, cost considerations, product purity requirements and other factors, the most suitable method is selected.

4-Chloropyridine-2-carboxylic acid amide, what is the price of this product in the market? I look at "Tiangong Kaiwu", although the price of this product is not detailed, it is also understood in business affairs, or can be deduced.
The price of various products in the market often varies according to factors such as quality, quantity, place and time. If 4-chloropyridine-2-carboxylic acid amide is of high quality, pure but free of impurities, its price must be higher than that of inferior quality. Quantity is also important, and if you buy it in bulk, the price may be reduced; if you buy it sporadically, the price will be high.
The distance of the place also depends on the price. The price of this product may be slightly lower in the place where it is produced, because it saves the cost of long-distance trafficking. If you ask for it in a remote place, add freight, customs duties, etc., and the price will be higher.
The price varies depending on the time. When the demand for this product is strong, such as in the pharmaceutical, chemical and other industries, the price must rise; if the demand is low, the price may decline.
Although it is difficult to determine the price range, it is common sense that if this product is retailed in small quantities of high quality in the city, it can range from tens of dollars per gram to hundreds of dollars; if it is wholesale in large quantities, it can be reduced to several dollars per gram depending on the amount. This is only a guess, the market conditions are ever-changing, and the actual price is subject to the current market.