4-Chloro-pyridine-2-carbonyl chloride

4-Chloropyridine-2-formyl chloride is an important compound in organic chemistry. Its physical properties are particularly critical, and it is related to many chemical processes and practical applications.
Looking at its appearance, under room temperature and pressure, 4-chloropyridine-2-formyl chloride is mostly colorless to light yellow liquid. This color characteristic can be visually distinguished by the naked eye in laboratory or industrial operation, which helps chemists to preliminarily determine its purity and state.
On odor, the compound emits a pungent and corrosive odor. This odor is strong and unique, warning people of its high chemical activity. Special attention should be paid during operation to avoid inhalation, because it is seriously irritating to the respiratory tract, eyes and skin. The boiling point and melting point of 4-chloropyridine-2-formyl chloride are also important physical properties. Its boiling point is about a specific temperature range, at which the compound changes from liquid to gaseous state. Precise control of the boiling point is crucial in chemical operations such as distillation and separation, which can help chemists effectively purify the substance. In terms of melting point, at a specific temperature, the compound changes from solid to liquid state, which is of great significance for the setting of storage and transportation conditions.
Furthermore, the solubility of 4-chloropyridine-2-formyl chloride cannot be ignored. Its solubility in organic solvents such as dichloromethane and chloroform is quite good. This property allows chemists to select suitable solvents in organic synthesis reactions according to the principle of similar miscibility, so as to promote the smooth progress of the reaction and improve the reaction efficiency and product purity.
And density is also a significant physical property of this compound. The density under specific conditions is indispensable for accurate measurement and calculation of the proportion of reactants, which directly affects the accuracy and controllability of chemical reactions. In conclusion, the physical properties of 4-chloropyridine-2-formyl chloride, such as appearance, odor, melting point, solubility, and density, are interrelated and affect each other, providing a key basis for many fields such as organic synthesis and chemical analysis, and playing an indispensable role in chemical research and industrial production.

4-Chloropyridine-2-formyl chloride is a crucial raw material in organic synthesis and has a wide range of uses in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate. The unique structure of Gainpyridine and chlorine atoms endows compounds with specific biological activities. Taking the preparation of antibacterial drugs as an example, by reacting with compounds containing active groups such as amino groups and hydroxyl groups, complex molecular structures with antibacterial effects can be constructed. The synthesis path of many antibacterial drugs relies on this substance to start, and through multi-step reactions, molecules that meet pharmacological requirements are precisely constructed.
Second, in the field of pesticide chemistry, it also plays an important role. The creation of pesticides often requires compounds with high efficiency, low toxicity and specific targets. 4-Chloropyridine-2-formyl chloride can be connected to various functional groups through a series of reactions to prepare pesticides with different modes of action such as contact, stomach toxicity or internal aspiration to pests. For example, some new insecticides contain structural fragments derived from the reaction of this substance in their molecular structures, which interfere with the physiological metabolism of pests to achieve the purpose of insecticide.
Third, in the field of materials science, it also shows its use. Can participate in the synthesis of some functional polymer materials. For example, the polycondensation reaction occurs with polymer monomers containing active end groups, and pyridine and chlorine elements are introduced into the main chain or side chain of the polymer, giving the material special electrical, optical or thermal properties. In the research and development of some new optoelectronic materials, this strategy is used, hoping to improve the material's response ability to optical signals or charge transfer efficiency with the help of the unique electron cloud distribution and reactivity of the material.
In summary, 4-chloropyridine-2-formyl chloride is an indispensable synthetic raw material in many fields such as medicine, pesticides and materials due to its own structural particularity, promoting the development and innovation of related technologies in various fields.

The synthesis of 4-chloropyridine-2-carbonyl chloride is very important and difficult. The synthesis method can follow the following steps.
First, 4-chloropyridine-2-carboxylic acid is used as the starting material. This raw material can be placed in the reaction vessel with sulfuryl chloride ($SOCl_2 $). Sulfuryl chloride is a commonly used chlorination reagent and plays a key role in this reaction. When the two react, it needs to be heated at a suitable temperature, generally between 60 and 80 ° C. When heated, the thionyl chloride reacts with the carboxyl group in the 4-chloropyridine-2-carboxylic acid, and the hydroxyl group of the carboxyl group is replaced by the chlorine atom, resulting in 4-chloropyridine-2-carbonyl chloride. At the same time, the thionyl chloride reacts to form sulfur dioxide ($SO_2 $) and hydrogen chloride ($HCl $) gas to escape. The chemical equation of the
reaction is as follows: 4 dollars - chloropyridine - 2 - carboxylic acid + SOCl_2\ stackrel {60 - 80 ℃} {\ longrightarrow} 4 - chloropyridine - 2 - carbonyl chloride + SO_2 ↑ + HCl ↑ $
During the reaction, many things should be paid attention to. First, the reaction vessel must be dry, because sulfuryl chloride is easily decomposed in contact with water, if there is water, it will seriously affect the reaction process and yield. Second, the reaction needs to be carried out in a well-ventilated environment, because the escape of sulfur dioxide and hydrogen chloride gas are both irritating and harmful to human health. Third, the reaction time also needs to be precisely controlled. If the time is too short, the reaction is not complete, and the yield is low; if the time is too long, it may cause side reactions, resulting in a decrease in the purity of the product.
After the reaction is completed, the product can be purified by vacuum distillation. Due to the volatility of 4-chloropyridine-2-carbonyl chloride, vacuum distillation can separate it from the unreacted raw materials and impurities at a lower temperature, thereby obtaining high-purity 4-chloropyridine-2-carbonyl chloride.
Although the steps of this synthesis are simple, fine caution is required when operating, and all links are related to the quality and quantity of the product. Mastering this synthesis method is of great benefit to the preparation of compounds containing such structures in the field of organic synthesis.

4-Chloropyridine-2-carbonyl chloride is a chemical substance. When storing and transporting, you must pay attention to many matters.
The first thing to store is to choose a cool, dry and well-ventilated place. This substance is afraid of moisture. If it is placed in a humid place, it is easy to cause deterioration. The temperature of the warehouse should be controlled within a certain range and should not be too high to prevent its chemical properties from changing. And it needs to be stored separately from oxidizing agents, alkalis and other substances. Because of its high chemical activity, contact with them or cause violent reactions, it is dangerous to health.
Furthermore, the storage place should be equipped with suitable containment materials to prevent leakage and can be properly handled in time. Packaging is also very important. It is necessary to ensure that it is tight and use high-quality packaging materials to ensure that there is no possibility of leakage.
When transporting, caution is also required. Transportation vehicles should have good ventilation equipment to disperse harmful gases that may be generated. Drivers and escorts must be familiar with the characteristics of this substance and emergency treatment methods. During transportation, it is necessary to prevent exposure to the sun, rain, and avoid high temperature and humid environments.
When loading and unloading, the operation must be gentle, do not collide or drag, to prevent leakage caused by package damage. If a leak unfortunately occurs, the surrounding personnel should be evacuated immediately, the contaminated area should be isolated, and the emergency response personnel need professional protective equipment. Collect and clean up the leak according to the correct method. Do not discard it at will to avoid polluting the environment.
All of these are important for the storage and transportation of 4-chloropyridine-2-carbonyl chloride, so as to ensure safety and avoid danger.

The market price range of 4-chloropyridine-2-formyl chloride is difficult to determine. The price of this chemical often changes for many reasons.
First, the trend of supply and demand is the key. If the market demand for 4-chloropyridine-2-formyl chloride is strong, but the supply is limited, the price will rise; conversely, if the supply is abundant and the demand is weak, the price may drop.
Second, the cost of raw materials has a significant impact. The production of this chemical requires specific raw materials. If the price of raw materials fluctuates, the price of finished products will also fluctuate. If the raw materials are scarce or the production cost increases, the price of 4-chloropyridine-2-formyl chloride will also increase.
Third, the difficulty of the preparation process is also related to the price. If the preparation method is complicated, high-end technology and equipment are required, and the production environment is strict, the cost is high, and the price is not low; if the process is simple, the cost may be reduced, and the price will follow.
Fourth, the market competition situation cannot be ignored. There are many manufacturers of this chemical in the market, and the competition is fierce. In order to compete for a share, there may be price reductions; if there are few manufacturers and the competition is weak, the price may rise steadily.
According to the past market, the price of 4-chloropyridine-2-formyl chloride may be between hundreds and thousands of yuan per kilogram. However, this is only an approximation. The current exact price needs to be consulted in detail with chemical product suppliers or on relevant chemical trading platforms.