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What are the main uses of 4-Chloro-3-Methoxy-2-Methylpyridine N-Oxide?
4-Chloro-3-methoxy-2-methylpyridine-N-oxide has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate. Due to its unique chemical structure, it can derive many bioactive compounds through various chemical reactions, which is of great help to the creation of new drugs. For example, it may participate in the construction of the core skeleton of a specific drug molecule, which in turn affects the interaction between the drug and the target, which is related to the efficacy and specificity of the drug.
It also plays an important role in the field of pesticide research and development. Or it can be chemically modified and converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities. With its chemical properties, it can effectively interfere with the physiological and metabolic processes of pests, pathogens or weeds, and achieve the purpose of control.
In the field of materials science, it may be used to synthesize functional materials. After specific reactions, the material is endowed with special properties such as light, electricity, magnetism, etc., which expands the path for the development of new materials. For example, in the synthesis of organic optoelectronic materials, its structural characteristics regulate the electronic transport performance of the material and improve the photoelectric conversion efficiency of the material. In conclusion, 4-chloro-3-methoxy-2-methylpyridine-N-oxide has shown important uses in many fields such as medicine, pesticides, and materials science due to its unique structure, providing key support for technological progress and innovation in related fields.
4-Chloro-3-Methoxy-2-Methylpyridine the synthesis of N-Oxide
To prepare 4-chloro-3-methoxy-2-methylpyridine-N-oxide, there are various methods. The common method is to use 4-chloro-2-methylpyridine as the starting material, methoxylated, and then oxidized.
Take 4-chloro-2-methylpyridine first, add an appropriate amount of alkali, such as potassium carbonate, to a suitable reactor, and then add methanol and a phase transfer catalyst, such as tetrabutylammonium bromide. Warm to a certain temperature to allow it to fully react. This step aims to introduce methoxy groups to generate 4-chloro-3-methoxy-2-methylpyridine. After the reaction, the pure intermediate is obtained by separation and purification methods, such as distillation and extraction.
The resulting 4-chloro-3-methoxy-2-methylpyridine is placed in another reaction system and a suitable oxidizing agent is added. A common oxidant is m-chloroperoxybenzoic acid (m-CPBA). In an organic solvent, such as dichloromethane, the oxidant is slowly added dropwise under low temperature conditions to make it fully react, so that the nitrogen atom on the pyridine ring is oxidized to N-oxide. After the reaction is completed, pure 4-chloro-3-methoxy-2-methylpyridine-N-oxide can be obtained by washing with water, drying, column chromatography, etc. < Br >
There are also other methods, such as using 2-methyl-3-methoxypyridine as raw material, chlorination first, and then oxidation. However, the chlorination step needs to control the reaction conditions to prevent the formation of polychlorinated substitutes, and subsequent separation and purification also requires fine operation. All methods have advantages and disadvantages. In actual synthesis, it is necessary to weigh and choose according to the availability of raw materials, cost and difficulty of reaction.
4-Chloro-3-Methoxy-2-Methylpyridine the physical properties of N-Oxide
4-Chloro-3-methoxy-2-methylpyridine-N-oxide is an organic compound with unique physical properties. It is usually in a solid state at room temperature and pressure, but the specific physical state may also vary depending on impurities or preparation conditions.
Looking at its appearance, it is usually a white to light yellow crystalline powder with a pure and uniform color, with few variegated colors or impurities mixed in. This compound has a certain melting point, about a specific temperature range, but the exact melting point is affected by purity and determination methods. Generally speaking, its melting point is relatively stable, which is one of the important indicators for the identification of this substance.
In terms of solubility, 4-chloro-3-methoxy-2-methylpyridine-N-oxide has different solubility in organic solvents. In common organic solvents such as ethanol and acetone, it exhibits good solubility and can dissolve quickly to form a homogeneous solution. However, in water, its solubility is poor and only slightly soluble. This difference in solubility provides an important basis for the separation, purification and application of this compound.
Furthermore, the density of this compound is specific. Although the exact value needs to be determined experimentally, its density has a certain range among similar organic compounds. Density is not only related to the relationship between material mass and volume, but also a key consideration in chemical production, storage and transportation.
In addition, the stability of 4-chloro-3-methoxy-2-methylpyridine-N-oxide is of concern. Under conventional environmental conditions, the compound has certain chemical stability and is not prone to spontaneous decomposition or other chemical reactions. However, under specific conditions such as strong acid, strong base or high temperature, light, etc., its chemical structure may change, decompose or participate in other reactions. Therefore, when storing, pay attention to environmental factors to avoid contact with unsuitable substances to ensure stability and quality.
4-Chloro-3-Methoxy-2-Methylpyridine the chemical properties of N-Oxide
The chemical properties of 4-chloro-3-methoxy-2-methylpyridine-N-oxide are quite unique. In its structure, chlorine atoms, methoxy groups interact with methyl and pyridine-N-oxide structures to create diverse properties.
In terms of reactivity, chlorine atoms can participate in nucleophilic substitution reactions under suitable conditions. Due to its high electronegativity, the connected carbon atoms are partially positively charged and vulnerable to attack by nucleophiles. If the nucleophilic reagent is a compound containing hydroxyl groups, amino groups, etc., it can replace chlorine atoms to form new pyridine derivatives. The
methoxy group exhibits a power supply effect, which can enhance the electron cloud density of the pyridine ring, which in turn affects the selectivity of the reaction check point. In the electrophilic substitution reaction, the reaction is more likely to occur at a specific position of the pyridine ring, which is different from the reaction without this substituent. Although the
methyl group is relatively small, it also affects the molecular reactivity and physical properties due to the steric resistance. It alters the spatial environment around the pyridine ring, and has an effect on some reactions that require spatial adaptation, or on intermolecular interactions, such as crystal accumulation and solubility.
The pyridine-N-oxide part has a certain degree of oxidation due to the oxidation of the nitrogen atom. At the same time, its alkalinity changes compared with pyridine, and it can participate in acid-base related reactions or form complexes with metal ions, showing different coordination chemical properties from pyridine precursors.
In addition, its physical properties cannot be ignored. Due to the molecular polarity being affected by each substituent, the solubility varies in different solvents. And the physical constants such as melting point and boiling point will also be different from pyridine precursors and other simple derivatives due to the change of intermolecular forces. This is because the substituents cooperate with each other to endow 4-chloro-3-methoxy-2-methylpyridine-N-oxide with unique chemical properties.
4-Chloro-3-Methoxy-2-Methylpyridine the price range of N-Oxide in the market
The price of 4-chloro-3-methoxy-2-methylpyridine-N-oxide in the market often varies according to many reasons. This compound is used in the chemical industry, medicine and other industries, and its demand and supply have a significant impact on its price.
If at a certain time, various industries are prosperous to it, but the producers are few, and the supply is not enough, its price may rise. On the contrary, if the supply exceeds the demand, the price may drop. And the price of raw materials for its preparation is also a major factor. The price of raw materials is high, the cost of preparation increases, and the price of this compound may also be high; the price of raw materials decreases, and the price may also decrease.
Furthermore, the difficulty of the preparation process is also related to its price. If the process is complicated, high-end equipment and exquisite skills are required, the cost will be high, and the price will follow; if the process is simple, the cost will be reduced, and the price may also be low.
In addition, the state of market competition is also involved. If there are many producers and the competition is intense, the price may be lower in order to compete for the market share; if there are few producers, the price may be controllable at a high level.
However, according to normal circumstances, in the chemical raw material market, the price of 4-chloro-3-methoxy-2-methylpyridine-N-oxide per kilogram may be between hundreds and thousands of yuan. This is only an approximate estimate, and the actual price is subject to changes in market conditions and the policies of various suppliers. If the buyer wants to know the exact price, he can consult the chemical raw material supplier, or check the quotation of the professional chemical product trading platform, before he can be trusted.
