4-Chloro-2-[(Methylamino)-Carbonyl]-Pyridine

4-Alkane-2-[ (methoxy) benzyl] pyridine is mainly used in many fields. In the field of medicinal chemistry, it can be used as a key intermediate to help develop new drugs. For example, when developing anti-cancer drugs with specific targeting properties, the unique structure of this compound can give drug molecules the ability to precisely act on specific targets of cancer cells, thereby improving the efficacy of anti-cancer drugs and reducing damage to normal cells. In the field of materials science, due to its unique chemical properties, it can be used to prepare special functional materials. For example, the preparation of organic semiconductor materials with excellent photoelectric properties and their application in organic Light Emitting Diodes (OLEDs) or organic solar cells can enhance the charge transfer efficiency of materials and improve the luminous efficiency or photoelectric conversion efficiency of devices. In the field of organic synthesis, as an important synthetic building block, organic compounds with complex structures and unique properties can be constructed through various chemical reactions. For example, by substitution and addition with different nucleophiles or electrophilic reagents, molecular structures can be expanded to obtain organic molecules with novel structures and specific functions, providing key raw materials and synthesis paths for the development of organic synthetic chemistry. Overall, 4-alkane-2-[ (methoxy) benzyl] pyridine plays an indispensable and important role in many scientific research and industrial production fields, and plays a key role in promoting technological innovation and development in related fields.

4-Ammonia-2- [ (methoxy) carbonyl] pyridine, this substance is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is mostly white to light yellow crystalline powder. This state is very common in many organic synthesis reactions, because its powder is easy to weigh, mix and participate in the reaction, which is quite convenient to operate.
Smell it, or it has a faint special smell. Although its taste is not as strong and pungent as some volatile substances, it can still be detected under specific circumstances. This smell is derived from the vibration and volatilization of specific functional groups in its molecular structure.
As for the melting boiling point, the melting point is roughly within a certain range, and the specific value will vary slightly due to factors such as purity. The characteristics of the melting point determine the temperature node at which it converts from solid to liquid during the heating process. It is of great significance to separate, purify and participate in the control of the reaction under specific temperature conditions. The same is true for the boiling point, which is related to the temperature required for its gasification and is crucial for separation operations such as distillation.
In terms of solubility, it exhibits a certain solubility in common organic solvents such as ethanol and acetone. This property allows for the selection of suitable solvents according to the reaction requirements in organic synthesis to promote full contact and reaction with other reactants, accelerate the reaction process and improve the reaction efficiency. In water, the solubility is relatively limited, which is due to the difference in the polarity of its molecules and the polarity of water molecules.
The density is slightly heavier or lighter than that of water. This property needs to be considered when it involves liquid-liquid separation and other operations to determine its location in the system and separation method.
The physical properties of 4-ammonia-2- [ (methoxy) carbonyl] pyridine play an important role in organic synthesis, drug development and other fields. The design and implementation of many reactions need to be carefully planned according to their properties.

4-Alkane-2- [ (methoxy) carbonyl] pyridine, which is an organic compound. Looking at its structure, it contains a pyridine ring, and the ring is connected with a specific substituent.
In terms of its chemical properties, the pyridine ring is basic to a certain extent, because the nitrogen atom has lone pair electrons and can accept protons. As an electron-withdrawing group, the methoxy carbonyl group will affect the electron cloud distribution of the pyridine ring, which in turn affects its basicity. From the perspective of reactivity, the presence of methoxy carbonyl groups makes the electron cloud density of the pyridine ring adjacent and para-position relatively low, and the meta-position is relatively high. Electrophilic substitution reactions may occur more easily in the meta-position. At the same time, methoxycarbonyl itself can undergo reactions such as hydrolysis and alcoholysis. When it encounters water, it can be hydrolyzed to carboxyl groups under appropriate conditions; when it encounters alcohols, it can occur alcoholysis to form corresponding esters. In addition, nitrogen atoms on the pyridine ring can coordinate with metal ions as ligands to form complexes, which may have applications in catalysis and other fields.
Overall, 4-alkane-2- [ (methoxy) carbonyl] pyridine has rich chemical properties and may have potential uses in organic synthesis, medicinal chemistry and other fields. Its specific structure determines the chemical properties, and the chemical properties lay the foundation for its application.

To prepare 4-alkyl-2- [ (methoxy) carbonyl] pyridine, there are many methods for its synthesis, and the most important ones are now.
First, it can be started by pyridine derivatives. Find a suitable pyridine compound, which needs to have a modifiable group at a specific position, such as a halogen atom. First, the halogenated pyridine and the reagent containing methoxy carbonyl are nucleophilic substitution in a suitable base and solvent environment. This reaction needs to be controlled at temperature and time to ensure that the reaction progresses in the expected direction, so that the halogen atom is replaced by a methoxy carbonyl group, and then the desired substituent is introduced.
Second, through the strategy of constructing a pyridine ring. Using chain compounds containing appropriate functional groups as raw materials, pyridine rings are formed by cyclization. If a suitable carbon chain length with specific active groups at both ends is selected, the chain molecules are cyclized under the specific reaction conditions of the catalyst, and methoxycarbonyl and alkyl are introduced at key positions. This process requires strict reaction conditions, and the choice of catalyst and the ratio of reactants are all about success or failure.
Third, metal-catalyzed coupling reactions can be used. The coupling reaction occurs with methoxycarbonyl-containing pyridinium boric acid derivatives and halogenated alkanes under the action of metal catalysts such as palladium catalysts. This reaction needs to be carried out in an inert gas protective atmosphere to avoid catalyst poisoning and side reactions. Precisely control the reaction parameters, such as temperature, catalyst dosage, reaction time, etc., to obtain the target product with higher yield and purity.
Furthermore, the method of functional group transformation can also be considered starting from the existing compounds with similar structures. First look for pyridine derivatives with similar structures, which have groups that can be converted into functional groups methoxycarbonyl and alkyl groups, and gradually modify them by a series of reactions such as oxidation, reduction, and substitution to obtain 4-alkane-2- [ (methoxy) carbonyl] pyridine. This approach requires precise control of each step of the reaction to ensure the selectivity and efficiency of functional group transformation.

Wen Jun inquired about the price range of 4-bromo-2- [ (methoxy) carbonyl] pyridine in the market. This compound, in the field of chemical industry, has a wide range of uses, and its price varies depending on quality, quantity and market conditions.
In normal condition, if it is a laboratory-grade pure product, it is purchased in small quantities, and the price per gram may be between tens and hundreds of dollars. For use in the laboratory, the purity is very high, and the preparation is also complex, so the price is high.
If it is an industrial grade, its price is slightly lower. However, for industrial use, it depends on the amount. If you buy in large quantities, such as kilograms, the price per kilogram may be between thousands of yuan due to the effect of scale.
In addition, the supply and demand of the market, the price of raw materials, and the technology of preparation can all make the price fluctuate. If the production of raw materials is suddenly reduced, or the technology of preparation is innovated, the price will change. In order to know the exact price, you should consult the chemical industry and compare their quotations to get a near-real price.