4 Chloro 2 3 5 6 Tetrafluoropyridine
pyridine pyrrole pyrazine piperidine piperazine

4-chloro-2,3,5,6-tetrafluoropyridine

    Specifications

    HS Code

    989977

    Chemical Formula C5ClF4N
    Appearance Colorless to light yellow liquid
    Boiling Point 118 - 120 °C
    Melting Point N/A
    Density 1.569 g/cm³
    Solubility In Water Insoluble
    Vapor Pressure N/A
    Flash Point 26 °C
    Refractive Index 1.407
    Pka N/A
    Logp 3.2

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    General Information
    Where to Buy 4-chloro-2,3,5,6-tetrafluoropyridine in China?
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    Frequently Asked Questions

    As a leading 4-chloro-2,3,5,6-tetrafluoropyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 4-chloro-2,3,5, 6-tetrafluoropyridine
    4-Chloro-2,3,5,6-tetrafluoropyridine is also an organic compound. It has a wide range of uses and plays an important role in many fields.
    Bearing the brunt, it is a key synthetic intermediate in the field of medicinal chemistry. It can be used to produce antibacterial, antiviral and anti-cancer drugs. Due to its special chemical structure, it can interact with specific targets in organisms and help build molecular structures with biological activity. For example, in the design of new antimicrobial drugs, 4-chloro-2,3,5,6-tetrafluoropyridine is used as the starting material, and through a series of chemical reactions, the molecules can be precisely modified to enhance the affinity and inhibitory effect of the drug on pathogens, making great contributions to human health.
    Furthermore, in the field of pesticide chemistry, it is also indispensable. It can be used to create highly efficient, low-toxicity and environmentally friendly pesticides. Such as the synthesis of new insecticides, fungicides, etc. With the unique structure of 4-chloro-2,3,5,6-tetrafluoropyridine, such pesticides exhibit excellent killing and inhibitory effects on crop pests and pathogens, while reducing the adverse effects on the environment and non-target organisms, and ensuring the sustainable development of agriculture.
    In addition, in the field of materials science, 4-chloro-2,3,5,6-tetrafluoropyridine is also useful. It can participate in the synthesis of polymer materials with special properties. It is introduced into the polymer chain through a specific polymerization reaction, giving the material unique properties such as corrosion resistance, high temperature resistance and electrical properties. These materials have broad application prospects in high-end fields such as electronic devices and aerospace.
    To sum up, 4-chloro-2,3,5,6-tetrafluoropyridine is an extremely important compound in many fields such as medicine, pesticides and materials science, and has contributed to the development of related industries.
    What are the synthesis methods of 4-chloro-2,3,5, 6-tetrafluoropyridine
    The synthesis method of 4-chloro-2,3,5,6-tetrafluoropyridine, through the ages, many parties have their own wonderful methods. Now let's describe its common methods.
    First, tetrafluoropyridine is used as the starting material, and the target product can be obtained by chlorination. Among the chlorinated agents, chlorine gas, thionyl chloride, etc. Under suitable reaction conditions, the chlorinated agent interacts with tetrafluoropyridine, and the chlorine atom replaces the hydrogen atom at a specific position on the pyridine ring to obtain 4-chloro-2,3,5,6-tetrafluoropyridine. The reaction conditions of this path may need to be precisely regulated. Temperature, pressure, reaction time, etc. are all related to the yield and purity of the product. If the temperature is too high, the product will be complex and difficult to distinguish; if the temperature is too low, the reaction will be slow and time-consuming.
    Second, there are also fluorine-containing and chlorine-containing basic compounds that are cyclized to form pyridine rings, and then 4-chloro-2,3,5,6-tetrafluoropyridine is synthesized. This process often requires the help of catalysts to promote the reaction. The basic compounds involved have exquisite structures and properties, which need to meet the mechanism and requirements of the cyclization reaction. The choice of catalyst is also key. Different catalysts have different activities and selectivity, which have a great impact on the process and results of the reaction.
    Third, by means of halogen exchange reaction, a specific halogenated pyridine is used as the substrate to exchange with fluoride. In this reaction, fluorine atoms gradually replace the halogen atoms on the halogenated pyridine ring, resulting in 4-chloro-2,3,5,6-tetrafluoropyridine. However, the halogen exchange reaction also faces challenges, and the activity difference of halides and the compatibility of the reaction system need to be carefully considered.
    All these synthesis methods have advantages and disadvantages. In practical application, when considering the availability of raw materials, cost considerations, product quality requirements and many other factors, careful choices can be made to achieve the best synthesis effect.
    What are the physical properties of 4-chloro-2,3,5, 6-tetrafluoropyridine
    4-Chloro-2,3,5,6-tetrafluoropyridine is one of the organic compounds. Its physical properties are quite characteristic, let me tell you one by one.
    Looking at its shape, under room temperature and pressure, 4-chloro-2,3,5,6-tetrafluoropyridine is often colorless to light yellow liquid, and its color is clear, just like the purity of autumn dew. From the visual, it can be seen that its fluidity is quite good, and it flows lightly in the container, like smart water.
    Smell its odor, this compound emits a unique pungent odor. Although the smell is not as pungent as the stench, it is also irritating to a certain extent. If people are close to it, they feel a little uncomfortable. This is due to its chemical structure.
    When it comes to the melting point, its melting point is about -20 ° C. At this temperature, the compound gradually solidifies from a liquid state, just like winter water condenses into ice. Its boiling point is about 134-136 ° C. When the temperature rises, the compound changes from a liquid state to a gaseous state, such as the rise of clouds.
    In terms of solubility, 4-chloro-2,3,5,6-tetrafluoropyridine is soluble in many organic solvents, such as ether and acetone. In ether, the two are like water emulsifying and dissolve each other, while in water, their solubility is relatively limited, due to the difference between the polarity of the compound itself and the polarity of water.
    Furthermore, its density is slightly larger than that of water. Placing it in one place with water shows that it sinks to the bottom of the water, just like a pearl sinking into the abyss, showing its unique physical properties. The vapor pressure of this compound is relatively low at room temperature and is not easy to volatilize. However, with the increase of temperature, the vapor pressure also increases, and the volatilization trend gradually becomes apparent.
    The physical properties of 4-chloro-2,3,5,6-tetrafluoropyridine are of great significance in the fields of organic synthesis. With its unique properties, it can provide opportunities for many chemical reactions and promote the progress and development of the chemical field.
    What are the chemical properties of 4-chloro-2,3,5, 6-tetrafluoropyridine
    4-Chloro-2,3,5,6-tetrafluoropyridine, this is an organic compound. Its unique chemical properties are crucial for the development of organic synthesis chemistry.
    First of all, its active substitution reaction. Due to the uneven distribution of electron clouds on the pyridine ring and the induction effect of chlorine atoms and fluorine atoms, the chlorine atoms in this compound are quite active. Under suitable conditions, chlorine atoms are easily replaced by nucleophiles. For example, by reacting with nucleophiles such as alkoxides and amines, corresponding substitution products can be successfully formed. This property provides an effective way to construct a variety of pyridine derivatives, which can be used in the field of medicinal chemistry to synthesize compounds with specific biological activities. < Br >
    Furthermore, its stability also has characteristics. The pyridine ring has a certain aromatic stability, and the presence of surrounding fluorine atoms further enhances its stability. Fluorine atoms have high electronegativity and form a large C-F bond energy, which makes the molecular structure more stable. This stability has a significant impact under extreme conditions such as high temperature, strong acid or strong base. Under moderate conditions, the structure can be maintained intact; but under severe conditions, although the stability is strong, the reaction may occur, but the required conditions are more demanding than ordinary pyridine derivatives.
    In addition, the fluorine atom of 4-chloro-2,3,5,6-tetrafluoropyridine has a profound impact on the electron cloud density of the pyridine ring due to its strong electron absorption. This not only changes the charge distribution on the ring, affects the selectivity of the substitution reaction check point, but also affects the physical properties of the compound, such as solubility and boiling point. Its solubility is different from that of ordinary pyridine compounds in organic solvents due to the increase of fluorine atoms, which brings special considerations for separation and purification in practical applications.
    In conclusion, the unique chemical properties of 4-chloro-2,3,5,6-tetrafluoropyridine, including active substitution reactions, specific stability, and fluorine atom effects, make it of great value and application potential in many fields such as organic synthesis and drug development.
    What is the price range of 4-chloro-2,3,5 6-tetrafluoropyridine in the market?
    The price of 4-chloro-2,3,5,6-tetrafluoropyridine in the market varies with time, place, and supply and demand conditions. Looking at the price changes of chemical materials in the past, the price of such fine chemicals is often intertwined by multiple factors.
    In the past market conditions, if the raw materials were abundant and the preparation method was advanced, the yield would increase, and the price would decrease. However, if the raw materials are scarce, and the production process is complicated and the energy consumption is high, the price will increase.
    According to the price status of similar fine chemicals in the past, the price of 4-chloro-2,3,5,6-tetrafluoropyridine may be between tens of thousands and hundreds of thousands of yuan per ton. If its application field expands, the demand increases greatly, and the supply is difficult to keep up in time, the price may rise; on the contrary, if the market competition is fierce and the production capacity is excessive, the price may decline.
    To get an accurate price, you should consult chemical product suppliers, traders, or refer to the real-time quotation of the chemical information platform, so that you can know the current exact price range.