4 Chloro 1h Pyrrolo 3 2 E Pyridine 5 Carbonitrile
pyridine pyrrole pyrazine piperidine piperazine

4-chloro-1H-pyrrolo[3,2-e]pyridine-5-carbonitrile

    Specifications

    HS Code

    202054

    Chemical Formula C8H4ClN3
    Molar Mass 177.59 g/mol
    Solubility In Water Low (due to non - polar nature of the pyrrole and pyridine rings)
    Solubility In Organic Solvents Likely soluble in common organic solvents like dichloromethane, chloroform, due to non - polar parts of the molecule
    Stability Stable under normal conditions, but reactive towards strong acids, bases, and oxidizing agents

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    What is the chemical structure of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile?
    The chemical structure of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile is also particularly important. The name of this compound has revealed many key elements of its structure.
    "4-chloro" means that the chlorine atom (chlorine atom) is connected to a specific position in the main ring, that is, the phase number 4. The chlorine atom, a member of the halogen group, has significant chemical activity. It often changes the physical and chemical properties of the compound, which has a considerable impact on the reactivity, polarity, etc.
    "1H-pyrrolo [3,2-e] pyridine" shows its main ring structure, which is formed by fusing pyrrole and pyridine rings. Pyrrole rings are nitrogen-containing five-membered heterocycles and have aromatic properties; pyridine rings are nitrogen-containing six-membered heterocycles and also have aromatic properties. The two are connected in a specific fused way, that is, the rule of [3,2-e], to construct a unique fused ring system. This fused ring structure gives the compound a special electron cloud distribution and spatial configuration, which affects its spectral properties, stability and reaction tendency.
    "5-carbonitrile", the carbonitrile group (-CN) is based on the check point of the main ring number 5. Cyanyl is a strong electron-absorbing group, which can polarize the intramolecular electron cloud, enhance molecular polarity, and significantly affect the reactivity and biological activity of compounds. It is often a key functional group in organic synthesis and can be converted into other important functional groups through various reactions, such as carboxyl groups, amide groups, etc.
    In summary, the chemical structure of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile is composed of a chlorine atom at a specific location, a unique fused pyrrolido-pyridine ring, and a connected cyano group. The interaction of the various parts endows the compound with unique chemical and physical properties, which is of great research value in organic chemistry and related fields.
    What are the main uses of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile?
    4-Chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile is an organic compound with a wide range of uses and important applications in various fields.
    In the field of medicinal chemistry, it is often used as a key intermediate. Due to its unique chemical structure, it can participate in a variety of drug synthesis reactions and help build complex drug molecular structures. By chemically modifying and derivatizing it, drugs with specific biological activities, such as anti-tumor drugs, can be developed. Researchers have ingeniously designed to use 4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile as the starting material, introducing specific functional groups, so that it can inhibit proliferation or induce apoptosis on tumor cells.
    In the field of materials science, it also has potential application value. Due to its structural properties, it may be used to prepare organic materials with special properties. For example, in the field of optoelectronic materials, through rational design and synthesis, materials with unique optoelectronic properties may be prepared, which can be applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve their performance and efficiency.
    In the field of pesticide chemistry, 4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile may also play an important role. It can be modified to develop pesticides that have high-efficiency killing or repelling effects on pests, and are environmentally friendly and reduce the impact on non-target organisms.
    4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile has great potential in the fields of medicine, materials, and pesticides. With the deepening of research, more novel applications may be discovered and expanded.
    What are the synthesis methods of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile?
    The synthesis method of 4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile covers a variety of pathways. First, the pyridine ring can be started by pyridine derivatives, and a suitable halogenating agent, such as a chlorine-containing halogenating agent, can be halogenated at a specific position under suitable reaction conditions to introduce chlorine atoms. This process requires precise regulation of the reaction temperature, time and ratio of reactants to prevent over-halogenation or formation of by-products.
    Furthermore, pyrrole derivatives are used as raw materials to construct pyridine rings through a series of condensation and cyclization reactions, and cyano groups are introduced at suitable stages. In the cyclization step, the selection of appropriate catalysts and reaction solvents is crucial, which may affect the yield and purity of the product. For example, some metal catalysts can promote the efficient cyclization reaction.
    There are also nitrile compounds as starting materials, and the target product is synthesized by nucleophilic substitution with chlorine-containing heterocyclic reagents. In this path, the activity of the reactants and the mildness of the reaction conditions need to be carefully considered to avoid product decomposition or unnecessary side reactions caused by severe conditions.
    The method of synthesis depends on the experimental conditions, the availability of raw materials and the purity of the target product. In practice, it is often necessary to repeatedly optimize the reaction parameters, carefully monitor the reaction process, or purify the product by means of column chromatography, recrystallization, etc., to obtain high-purity 4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile.
    What are the physical properties of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile?
    4-Chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile is an organic compound. Its physical properties are very important, and it is related to the behavior of this compound in various scenes.
    First of all, its appearance is usually solid or crystalline. It can be seen that it has a specific crystal structure. This structure affects its reflection and refraction of light, giving its surface a unique luster.
    The melting point is one of the key physical properties. The value of its melting point depends on the strength of intermolecular interactions. If the intermolecular force is strong, a higher temperature is required to overcome it, resulting in an increase in the melting point; otherwise, it is low. The melting point of 4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile varies depending on the conditions of accurate determination, but it generally falls within a specific temperature range, which is very important for the identification and purification of this compound.
    Solubility is also a significant physical property. In common organic solvents, such as ethanol, dichloromethane, etc., their solubility varies. In ethanol, according to the principle of similar dissolution, if the molecular polarity is similar to ethanol, it can be partially dissolved; in dichloromethane, because its non-polarity is slightly stronger, if the compound has a certain non-polar region, it may have better solubility. This difference in solubility is an important basis for selecting a suitable solvent in the separation, purification and synthesis reaction post-processing steps.
    Furthermore, density is also a category of physical properties. Its density reflects the quality of the substance in a unit volume. This property is related to the measurement and transportation of materials in chemical production. If its density is known, the quality of the compound in a specific volume can be accurately calculated to ensure the accuracy of the production process.
    In addition, its volatility also needs to be considered. Those with low volatility are more difficult to convert from liquid to gaseous state at room temperature and pressure. This property is related to the intermolecular force and boiling point, and has certain requirements for storage and use environment. Low volatility can reduce its loss in the air, which is beneficial to preservation.
    In summary, the physical properties of 4-chloro-1H-pyrrolido [3,2-e] pyridine-5-formonitrile, such as appearance, melting point, solubility, density and volatility, are of crucial significance in organic chemistry research, chemical production and related fields, laying the foundation for in-depth understanding and effective utilization of this compound.
    How much is 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile in the market?
    The price of 4-chloro-1H-pyrrolo [3,2-e] pyridine-5-carbonitrile in the market is what you ask. However, it is difficult to determine the price of this chemical substance. The price often varies due to multiple factors.
    First, the level of purity has a great impact. If the purity is extremely high, almost perfect, and can be used in many high-end experiments and fine chemicals, the price will be high. On the contrary, if the purity is slightly lower, it is only suitable for general basic research or occasions where the requirements are not harsh, and the price is low.
    Second, the amount of output is also the key. If manufacturers produce in large quantities and supply is sufficient, prices may stabilize or even decrease according to market supply and demand. However, if output is scarce and supply exceeds demand, prices will soar.
    Third, the cost of raw materials cannot be ignored. It is difficult to obtain raw materials, and the price fluctuations will be transmitted to the substance. If raw materials are scarce, procurement is difficult, and costs increase sharply, their selling prices will also rise.
    Fourth, the market competition situation also affects the price. When many merchants compete to sell, in order to compete for share, there may be price reductions. If the market is close to monopoly, the price is easy to be manipulated and is at a high level.
    In my opinion, if you want to know the exact price of this product, you can get a more accurate figure by visiting chemical raw material suppliers and reagent sales platforms and inquiring about its price in detail. It must not be based on speculation alone, but must be subject to actual inquiry.