4-Chloro-1H-pyrrolo[2,3-尾]pyridine

4-Chloro-1H-pyrrolido [2,3-b] pyridine is one of the organic compounds. It has a wide range of uses and is widely used in the field of medicinal chemistry.
First, it is often used in drug development. According to the principles of modern medicine, many drug molecules with specific pharmacological activities are constructed, and this compound is often relied on as the key starting material or intermediate. Due to its unique chemical structure, it endows the derived drugs with unique biological activities and mechanisms of action. For example, its structure can be modified and modified to precisely combine with specific biological targets, so as to achieve the purpose of treating diseases. In the research of anti-tumor drugs, some compounds designed and synthesized on this basis have been experimentally verified to show significant inhibitory activity on some tumor cells.
Second, it also has potential in the field of materials science. With the development of materials chemistry, the demand for functional organic materials is increasing. 4-chloro-1H-pyrrolido [2,3-b] pyridine can be used as a basic unit for constructing functional materials. Due to its special electronic structure and chemical properties, through rational design and assembly, it is expected to prepare materials with unique photoelectric properties, such as applications in organic Light Emitting Diodes (OLEDs), organic solar cells and other fields, providing new ideas and approaches for the development of new functional materials.
Third, in organic synthetic chemistry, this compound is also an important synthetic block. Chemists can build more complex and diverse organic molecular structures through various chemical reactions, such as nucleophilic substitution and coupling reactions, according to the strategies and methods of organic synthesis, and use its active reaction check points to inject vitality into the development of organic synthetic chemistry.

4-Chloro-1H-pyrrolido [2,3-b] pyridine is a genus of organic compounds. Its physical properties are unique, related to the properties of the substance, melting point, boiling point, solubility and other characteristics, and are quite important in chemical research and practical applications.
First of all, its appearance, at room temperature, 4-chloro-1H-pyrrolido [2,3-b] pyridine is mostly in a solid state, and it is often white or off-white crystalline powder, which is easy to observe and handle.
For the melting point, the critical temperature at which the substance changes from solid to liquid is also the same. The melting point of 4-chloro-1H-pyrrolido [2,3-b] pyridine is about 135-139 ° C. The determination of the melting point is an important basis for identifying the purity of the compound and distinguishing it from others. The boiling point of the
is also a key physical property. Although the compound is easily decomposed by heat and the exact boiling point is difficult to determine accurately, it can be known that under certain pressure conditions, when it reaches a certain temperature, it will change from liquid to gaseous. < Br >
In terms of solubility, 4-chloro-1H-pyrrolido [2,3-b] pyridine exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property is conducive to the selection of suitable solvents in organic synthesis reactions, so that the reaction can proceed smoothly. In water, its solubility is poor, due to the scarcity of hydrophilic groups in the molecular structure of the compound and strong hydrophobicity.
Density is the mass per unit volume. The density of 4-chloro-1H-pyrrolido [2,3-b] pyridine is about 1.45 g/cm ³. This value can be considered in the separation and mixing of substances.
In addition, the compound has a certain stability. When it encounters strong oxidizing agents, strong acids, and strong bases, the structure may change, resulting in changes in properties. And it also has a certain sensitivity to light and heat. Under high temperature or strong light irradiation, decomposition and isomerization may occur.
In summary, the physical properties of 4-chloro-1H-pyrrolido [2,3-b] pyridine, such as appearance, melting point, solubility, density and stability, play an indispensable role in many fields such as organic synthesis and drug development, laying an important foundation for related research and applications.

The chemical synthesis method of 4-chloro-1H-pyrrolido [2,3-b] pyridine is a very important topic in the field of organic synthesis. The synthesis method often follows various paths.
First, it can be started from a specific pyridine derivative. First, chlorine atoms are introduced at a specific position in the pyridine ring with a suitable halogenation reagent. This halogenation step requires fine regulation of the reaction conditions, such as temperature, solvent and reactant ratio, to ensure that the chlorine atoms precisely replace the target position. Subsequently, the core structure of pyrrolido [2,3-b] pyridine is constructed by cyclization reaction. The cyclization process may involve reaction mechanisms such as nucleophilic substitution and condensation. Appropriate catalysts and reaction media need to be selected to promote the efficient reaction.
Second, pyrrole derivatives are also used as starting materials. First, the pyrrole ring is appropriately modified, and functional groups that can be related to the construction of the pyridine ring are introduced. Then, through a series of reactions, the pyridine ring is connected to the pyrrole ring and forms a ring. In this process, the control of the reaction sequence and conditions is crucial. A slight difference in pooling can easily lead to side reactions, which affect the yield and purity of the target product.
In addition, there is a strategy to gradually build the skeleton of the target molecule through a multi-step reaction. The intermediate containing part of the structure is first synthesized, and then the functional group conversion, ligation and other reactions are carried out to finally combine to form 4-chloro-1H-pyrrolido [2,3-b] pyridine. Although there are many steps in this pathway, the selectivity and controllability of each step of the reaction are extremely high, and each step of the reaction needs to be carefully optimized to achieve the desired synthetic effect.
There are many methods for synthesizing 4-chloro-1H-pyrrolido [2,3-b] pyridine, but each method needs to be based on the actual situation, considering many factors such as the availability of raw materials, the feasibility of reaction conditions, the yield and purity of the product, and carefully selecting the appropriate synthetic route.

The price of 4-chloro-1H-pyrrolido [2,3-b] pyridine in the market is difficult to determine. This is due to many reasons.
First, the preparation method is quite complicated, and it needs to go through multiple steps of reaction. The control of the reaction conditions of each step and the purity of the raw materials will cause the cost to fluctuate. If the preparation process is exquisite, the raw materials are easy to obtain and the price is low, or the cost can be slightly reduced; on the contrary, if the process is difficult and the raw materials are scarce and expensive, the cost will be high, which will affect the market price.
Second, the supply and demand of the city is also the key. If there is a large increase in demand for this product in the fields of pharmaceutical research and development, chemical synthesis, etc., but the supply is limited, its price may rise; if the demand is weak and the supply is sufficient, the price may fall.
Third, different manufacturers have different pricing strategies. Large factories may be able to sell it at a more reasonable price due to the benefits of scale and technology; small factories may not be able to control costs, and the price may be high.
And the market conditions are changing rapidly. The price of 4-chloro-1H-pyrrole [2,3-b] pyridine will be affected by the fluctuation of raw material prices, changes in policies and regulations, and increases and decreases in transportation costs. Therefore, in order to know the exact price range between markets, it is necessary to constantly observe market dynamics, consult suppliers, and comprehensively consider various factors to obtain a more accurate price. However, it is difficult to specify its specific price range at this moment.

4-Chloro-1H-pyrrolido [2,3-b] pyridine is an organic compound. Its storage conditions are crucial to the stability and quality of this substance.
Those who bear the brunt must be placed in a cool place. High temperature can easily cause it to undergo chemical reactions and damage its inherent properties. In a cool place, the temperature is often relatively constant, which can avoid its deterioration due to large changes in temperature.
Second, drying is also the key. If this substance is in a humid environment, it is easy to absorb moisture, or cause reactions such as hydrolysis, causing its structure and properties to change. Therefore, it should be stored in a dry place, and the environment can be maintained dry with desiccants and other substances.
In addition, sealed storage is also indispensable. If exposed to air, it is easy to interact with oxygen, carbon dioxide and other components in the air. Sealing can prevent it from contacting with external substances and ensure the stability of its chemical properties.
Also, the storage place should be away from fire and heat sources. This compound may be flammable and may be dangerous in case of fire or hot topic, such as the risk of combustion or explosion.
And when stored, it should be stored separately from oxidizing agents, acids, bases and other substances. Due to the chemical properties of the compound, or violent reaction with such substances, safety is endangered.
In conclusion, 4-chloro-1H-pyrrolido [2,3-b] pyridine should be stored in a cool, dry, sealed place, away from fire and heat sources, and separated from other substances that may react, in order to ensure its quality and safety.