4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

4-Chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid, this is an organic compound. Looking at its name, its chemical structure can be analyzed according to the nomenclature of organic chemistry.
"pyrazolo [3,4-b] pyridine", this is the parent nucleus structure. Pyrazole fused with pyridine to form this specific parent nucleus, "[3,4-b]" calibrates the position of pyrazole and pyridine. "1H" represents the hydrogen atom at position 1. " 1-Ethyl ", indicating that the hydrogen at the 1 position is replaced by ethyl, and the ethyl group is -C ² H." 4-Chlorine ", that is, there is a chlorine atom at the 4th position of the parent nucleus pyrazolo [3,4-b] pyridine, and the chlorine atom is -Cl." 5-carboxylic acid ", indicating that there is a carboxyl group connected at the 5th position, and the carboxyl group is -COOH.
In summary, the structure of this compound is: with pyrazolo [3,4-b] pyridine as the parent nucleus, ethyl at the 1st position, chlorine atom at the 4th position, and carboxyl at the 5th position. In organic chemistry, such structures are often associated with specific chemical properties and reactions, or are involved in the research of pharmaceutical chemistry, material chemistry, and other fields.

4-Chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid, this is an organic compound. Looking at its structure, it contains chlorine atoms, ethyl groups, pyrazolo-pyridine rings and carboxyl groups, and its physical properties are greatly affected by the interaction of these groups.
First, the appearance is usually solid. Due to the existence of various forces between molecules, such as van der Waals force and hydrogen bonds, the molecules are arranged in an orderly manner to form a solid structure. Its color may be white to off-white, which is due to the absorption and reflection characteristics of the compound's molecular structure to light. It does not contain a large number of conjugated systems, so it does not have a significant chromophore, showing a light color.
In terms of melting point, the melting point of the substance may be relatively high. Carboxylic groups can form intermolecular hydrogen bonds, enhance intermolecular forces, and increase the lattice capacity. A higher temperature is required to destroy the lattice and cause it to melt. However, the specific melting point value needs to be accurately determined by experiments, because it is also affected by impurities, crystal structure and other factors.
In terms of solubility, since the carboxylic group is a hydrophilic group, it can form hydrogen bonds with water molecules, so it may have a certain solubility in water. However, there are still hydrophobic parts such as chlorine atoms, pyridine rings and pyrazole rings in the molecule, which limit their solubility in water or are only slightly soluble in water. In organic solvents, polar organic solvents such as dichloromethane and chloroform have similar dipole-dipole interactions with the compound molecules, and their solubility may be better than water; in non-polar solvents such as n-hexane, the solubility is very small, because of the weak force between the molecules of the non-polar solvent.
The density may be greater than that of water. Due to the chlorine atoms in the molecule, the relative atomic mass of the chlorine atoms is larger, which increases the molecular mass, and the molecular structure is compact, so the mass per unit volume increases, so the density is greater than that of water. < Br >
The physical properties of this compound are of great significance for its application in organic synthesis, drug development and other fields. Knowing its solubility can provide a basis for the selection of reaction solvents; knowing the melting point is conducive to product purity identification and separation and purification.

The synthesis of 4-chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid has attracted much attention in organic synthetic chemistry. This compound has shown potential application value in many fields such as medicine and pesticides, so the study of its synthesis method is of great significance.
One of the common synthetic routes is to start with a compound containing a pyridine structure. First, a suitable substituent is introduced at a specific position of the pyridine ring, and the corresponding check point on the pyridine ring is connected to a chlorine atom through halogenation reaction. After that, the pyridine ring structure is constructed through specific reaction conditions. This process requires precise regulation of the reaction temperature, reaction time, and the proportion of reactants to ensure that the pyrazole ring is formed at the correct regioselectivity. For example, under basic conditions, the nitrogen-containing nucleophile reagent can be cyclized with the pyridine derivative to form the parent nuclear structure of pyrazolo [3,4-b] pyridine. Next, the parent nuclear structure is modified. In a suitable step, ethyl is introduced at the target position. A nucleophilic substitution reaction can be used to react with the corresponding intermediate with halogenated ethane to achieve the introduction of ethyl. Finally, a carboxyl group is introduced into the 5-position of the pyridine ring through a specific carboxylation reaction, such as a metal-catalyzed carboxylation reaction, so that the intermediate reacts with carbon dioxide under suitable catalyst and reaction conditions to generate the target product 4-chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid.
The second synthesis strategy is to use the pyrazole ring as the starting building block. Pyrazole compounds with suitable substituents are first synthesized, and then the structure of pyrazolo [3,4-b] pyridine is formed by condensation reaction with pyridine derivatives. In this process, the reaction conditions also need to be carefully controlled to achieve precise introduction and linking of each substituent. In the synthesis of pyrazole rings, different starting materials and reaction routes can be selected to optimize the synthesis efficiency and product purity.
There are various methods for synthesizing 4-chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acids. Researchers need to choose and optimize the synthesis route according to actual needs and conditions to achieve the purpose of efficient and high-purity synthesis.

4-Chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid has a wide range of uses in the field of pharmaceutical chemistry and organic synthesis.
It is often a key intermediary in the development of medicine. Due to its unique chemical structure, it can participate in a variety of reactions to build complex molecular structures with biological activity. By modifying and modifying its structure, medical scientists can create new types of drug molecules to fight various diseases. For example, for specific disease targets, design and synthesize compounds that are compatible with them, or can be used to treat inflammation, tumors and other diseases. The specific functional groups contained in this compound can interact with target proteins in organisms, inhibit the activity of enzymes, or regulate signaling pathways, and then exhibit therapeutic effects.
In the process of organic synthesis, it is an important building block. Chemists can use various organic reactions, such as nucleophilic substitution, electrophilic substitution, coupling reaction, etc. based on this compound to expand its structure and synthesize a series of derivatives. These derivatives also have potential uses in materials science, pesticide chemistry and other fields. For example, in materials science, materials with special optical and electrical properties can be prepared; in pesticide chemistry, high-efficiency and low-toxicity pesticides can be created.
Furthermore, it is also an ideal substrate for exploring reaction mechanisms and new synthesis methods in chemical research. By using it as a raw material for reactions, researchers can gain in-depth insight into the reaction process, optimize reaction conditions, and promote the progress of organic chemistry theory and technology.

What is the price of 4-chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid in the market? This is a specific chemical of fine chemicals, but its market price range is difficult to determine, and it is mostly due to various reasons.
The simplicity of its preparation process is related to the cost and price. If the preparation method is complicated, multiple processes are required, rare reagents are used, or the reaction conditions are strict, such as precise temperature, pressure and catalyst, etc., the cost will be high and the price will be expensive.
Furthermore, the state of market supply and demand also affects its price. If there is a strong demand for this product in the fields of pharmaceutical research and development, materials science, etc., but the supply is limited, the price will rise; on the contrary, if the demand is weak and the supply is abundant, the price will tend to fall.
And different manufacturers, due to different technical levels, production scale and cost control, pricing is also different. Large factories have scale effects and advanced technologies, costs may be lower, and prices may be more affordable; small factories are the opposite.
And fluctuations in raw material prices have a great impact on their prices. If raw materials are scarce or prices change frequently, the price of 4-chloro-1-ethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylic acid also fluctuates.
Generally speaking, in the chemical raw material market, the price per gram may range from tens to hundreds of yuan. If it is high purity and special specifications, the price may be higher, up to thousands of yuan per gram. To know the exact price, consult chemical product suppliers, trading platforms, or research at industry exhibitions to get accurate prices.