4-Chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxylic ac

4-Chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate for the synthesis of many specific drugs. Geinpyrazolo-pyridine compounds often have unique biological activities and can precisely act on specific biological targets, such as certain kinases. Using 4-chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid as the starting material, through multiple steps of delicate organic synthesis, innovative drugs with excellent efficacy for specific diseases can be prepared, such as targeted therapeutic drugs for certain tumor diseases.
In the field of pesticide chemistry, it also plays an important role. Compounds constructed on this basis may have good insecticidal and bactericidal activities. After rational structural modification and optimization, the derived pesticide products can effectively resist crop diseases and pests, and are relatively friendly to the environment, contributing to sustainable agricultural development. For example, in the research and development of new fungicides, using their structural characteristics, products that can effectively inhibit the growth and reproduction of common crop pathogens can be developed to ensure the robust growth of crops and improve the yield and quality of agricultural products.
Furthermore, in the field of materials science, some functional materials that are synthesized by them may have special optical and electrical properties. After scientific preparation and processing, it can be applied to the preparation of advanced materials such as organic Light Emitting Diode (OLED) and sensors. In the synthesis of OLED materials, with its unique molecular structure, the luminous efficiency and stability of materials can be improved, and the progress of display technology can be promoted.

The synthesis method of 4-chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid is not contained in the classic "Tiangong Kaiwu", but the theory of creation recorded in the book can inspire the synthesis idea.
Now to synthesize this acid, you can first observe its structure and find related starting materials. According to the usual method of organic synthesis, you can first use an appropriate pyridine derivative as the base. This derivative needs to contain the activity check point that can introduce chlorine, methyl and construct a pyrazole ring.
Or you can first take a pyridine containing an appropriate substituent and introduce a chlorine atom at a suitable position by halogenation. When halogenating, choose the appropriate halogenating reagent and reaction conditions, such as chlorination reagent under the action of appropriate solvent, temperature and catalyst, so that the chlorine atom can be precisely replaced.
Then, the methyl group is introduced by alkylation. Alkylation requires the selection of appropriate alkylating reagents, such as halomethane, etc., with a suitable base and reaction environment, so that the methyl group is attached to the designated position of the pyridine ring.
As for the construction of the pyrazole ring, a nitrogen-containing bifunctional reagent can be used to cyclize with the pyridine derivative. This cyclization reaction requires careful regulation of reaction conditions, such as temperature, reaction time, and ratio of reactants, so that the pyrazole ring is correctly formed and the pyridine ring forms the established pyrazolo [3,4-b] pyridine structure.
Finally, through the carboxylation step, the carboxyl group is introduced at a specific position to complete the synthesis of 4-chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid. The carboxylation can be based on the common carboxylation method, and the appropriate carboxylation reagent and reaction conditions can be selected to achieve the purpose of synthesis. Although the synthesis of this acid is not detailed in "Tiangong Kaiwu", it can be synthesized according to the principles of chemistry and the methods of predecessors.

4-Chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid This substance belongs to the category of chemistry. Its physical properties, let me describe in detail.
Looking at its shape, at room temperature, it is mostly in the shape of a solid state. Its shape may be crystalline, and the crystal form is regular, with a certain geometric configuration, showing the wonderful law of nature. Its color is often plain, or white like first snow, or nearly colorless transparent, pure and free of variegated dye.
Smell the smell, there is no pungent smell, nor is there a fragrant fragrance. The smell is indifferent and peaceful, and does not disturb people's sense of smell.
As for its melting point, the melting point is in a specific temperature range, which is the critical point for the transformation of matter from solid to liquid. This melting point temperature is of great significance in terms of the characteristics of the compound, which is related to its physical state changes under different thermal environments. The boiling point determines the conditions for its transformation between gaseous and liquid states, and can only be transformed into gaseous substances at high temperatures.
In terms of solubility, in water, the degree of solubility is limited. Due to the characteristics of molecular structure, the interaction with water molecules is not very strong. However, organic solvents, such as ethanol and acetone, exhibit good solubility, can blend with organic solvents, and disperse uniformly. This property is important in many operations such as chemical synthesis, separation and purification.
Density is also one of its important physical properties. A specific density value indicates the mass of the substance contained in a unit volume and reflects the compactness of its molecular accumulation. This property is useful in the identification and separation of substances.
In summary, the physical properties of 4-chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acids have laid the foundation for their research and application in the field of chemistry. Many properties are interrelated, which together outline the unique physical properties of this compound.

4-Chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid, the chemical properties of this substance are as follows:
First of all, it is acidic. Because of its carboxyl group, the oxygen atom in the carboxyl group has strong electronegativity, which makes the hydrogen-oxygen bond electron cloud biased towards oxygen, and hydrogen is easily dissociated in the form of protons, so it is acidic and can neutralize with bases. In case of sodium hydroxide, the corresponding carboxylate and water will be formed.
Secondly, the presence of halogen atom chlorine makes the compound nucleophilic substitution reaction activity. Because the chlorine atom has a certain electronegativity and is connected to the pyridine ring, the carbon atom attached to the chlorine atom is partially positively charged and vulnerable to attack by nucleophiles. Nucleophiles such as sodium alcohol and amines can replace chlorine atoms to form new compounds and expand their derivatization possibilities.
Furthermore, the pyrazolo-pyridine ring endows it with certain aromaticity and stability of the conjugate system. This conjugate system affects the distribution of electron clouds, alters the reactivity and spectral properties of the compound. Based on the aromaticity, the compound can undergo some electrophilic substitution reactions. Under suitable conditions, the electrophilic reagents can attack specific positions on the pyridine ring or the pyrazole ring to form new derivatives.
In addition, the interaction of various groups in the molecule affects the overall chemical properties. The effect of methyl power supply can change the electron cloud density on the ring and affect the selectivity of electrophilic and nucleophilic reactions. The effect of carboxyl groups on the electron cloud density of the pyridine ring is also related to the substituents on the ring, which jointly determine the reactivity and selectivity of compounds.
In short, the chemical properties of 4-chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acids are rich, laying the foundation for research and application in the fields of organic synthesis and medicinal chemistry.

I don't know the market price of 4-chloro-1,3-dimethylpyrazolo [3,4-b] pyridine-5-carboxylic acid. This compound is very common, and its price may vary depending on purity, source, and purchase quantity.
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