4-BROMOTHIENO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Methyl 4-bromothiopheno [2,3-c] pyridine-2-carboxylate has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate for the synthesis of many specific drugs. Based on the unique physiological activity of the structure of Geiinthiopheno-pyridine, chemists can construct a variety of drug molecular architectures. For example, when developing targeted therapeutic drugs for specific diseases, this compound can precisely design the interaction between the drug and the target of diseased cells, greatly improve the efficacy and selectivity of the drug, and reduce the damage to normal cells.
In the field of materials science, it also has important functions. Because its structure gives special optoelectronic properties, it can be applied to the preparation of organic optoelectronic materials. For example, in the manufacture of organic Light Emitting Diode (OLED), the addition of this compound or its derivatives can optimize the luminous efficiency and stability of the material, so that the image quality of the display screen is clearer and the color is more gorgeous. In addition, in the research and development of solar cells, it can be used as a photosensitive material component to enhance the capture and conversion efficiency of light energy by the battery, and promote the development of solar energy utilization technology.
Furthermore, in the field of pesticide chemistry, this raw material can be used to synthesize pesticides with high insecticidal and bactericidal properties. Its unique structure helps to improve the poisoning effect of pesticides on specific pests and bacteria, while reducing the impact on the environment and non-target organisms, which is in line with the current development trend of green pesticides. In conclusion, methyl 4-bromothieno [2,3-c] pyridine-2-carboxylate plays an indispensable role in many fields and is of great significance to scientific and technological progress and industrial development.

The synthesis method of 4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid methyl ester, although the ancient book "Tiangong Kaiwu" does not contain this material, it can be deduced according to the ancient ideas and modern chemical principles.
First, the compound containing the structure of pyridine and thiophene is used as the starting material. First, the condensation reaction of pyridine and thiophene under suitable conditions occurs to construct the basic structure of thiopheno [2,3-c] pyridine. Among them, a good solvent, such as dichloromethane or N, N-dimethylformamide, is needed to help the reactants to mix evenly and promote the smooth reaction. It is also necessary to find a suitable catalyst, such as Lewis acid, to reduce the activation energy of the reaction and increase the reaction rate.
Second, bromine atoms are introduced into the above products. The electrophilic substitution reaction can be used to introduce bromine atoms into the appropriate position of thiopheno [2,3-c] pyridine under appropriate conditions, such as bromine or N-bromosuccinimide (NBS). This step requires precise temperature control and timing control to prevent side reactions, such as the formation of polybrominated products.
Third, methyl carboxylate is prepared. First, thiopheno [2,3-c] pyridine containing bromine is reacted with a suitable carboxylation reagent to introduce a carboxyl group, and then methanol is used to react with the carboxyl-containing product under acid catalysis to obtain 4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid methyl ester. Among them, the acid catalyst can be selected from sulfuric acid or p-toluenesulfonic acid, and the reaction needs to be under reflux conditions to ensure that the reactants are fully contacted and the reaction is complete. < Br >
After each step of the reaction, appropriate separation and purification methods, such as column chromatography, recrystallization, etc., are required to remove impurities and extract the purity of the product to obtain pure 4-bromothiopheno [2,3-c] methyl pyridine-2-carboxylate.

I look at the "4 - BROMOTHIENO [2,3 - C] PYRIDINE - 2 - CARBOXYLIC ACID METHYL ESTER" you are inquiring about, which is a fine chemical in the field of chemistry. However, its market price often varies depending on time, place, quality and changes in supply and demand.
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If in a busy commercial port, supply and demand are booming, its price may stabilize due to competition. If the quality is high and the supply is sufficient, the price per gram may be between tens and hundreds of yuan. However, in remote places, or due to difficult logistics and imbalance between supply and demand, the price may rise and fall. If raw materials are scarce and the process is complicated, the price will also rise, or exceed 100 yuan per gram, or even higher.
The chemical market is changing, and the price of yesterday cannot be accurate today. Therefore, in order to obtain an accurate price, you need to constantly observe market dynamics, inquire from many parties, and check recent transaction records in detail, so as to have an idea and meet the needs of business.

Methyl 4-bromothiopheno [2,3-c] pyridine-2-carboxylate is an organic compound. Its physical and chemical properties are quite important and are related to many fields of application.
First, the appearance is often solid at room temperature and pressure, mostly white to light yellow powder or crystal. This is due to the orderly arrangement of atoms in the molecular structure, and the intermolecular forces make the substance appear in this shape.
The melting point is also a key physical property, about [X] ° C. This value may vary due to slight differences in measurement conditions. The melting point depends on the strength of the intermolecular forces. There are interactions such as van der Waals forces and hydrogen bonds between the molecules of the compound, which maintain the solid structure. When the temperature rises to the melting point, these forces are weakened, and the substance changes from solid to liquid.
In terms of boiling point, under a specific pressure, it is about [Y] ° C. The determination of boiling point is related to the relative mass of the molecule and the intermolecular forces. The greater the relative mass and the stronger the intermolecular forces, the higher the boiling point.
The solubility cannot be ignored either. In organic solvents such as dichloromethane and N, N-dimethylformamide, it exhibits good solubility. Due to the principle of similar miscibility, the compound molecule is compatible with the force between the organic solvent molecules and can be uniformly dispersed. However, in water, the solubility is poor. Because of the large difference between the molecular polarity and the polarity of the water molecule, it is not easy to form a stable dispersion system.
From the perspective of chemical properties, bromine atoms in its molecules have high reactivity and can participate in nucleophilic substitution reactions. For example, with nucleophilic reagents such as sodium alcohol and amine compounds, bromine atoms can be replaced under suitable conditions to form new compounds and expand their application in the field of organic synthesis.
In addition, the ester group is also reactive and can undergo hydrolysis reaction. Under acidic or basic conditions, the ester group can be broken, and hydrolyzed under acidic conditions to form 4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid and methanol; under alkaline conditions, the hydrolysis is more thorough, resulting in carboxylic salts and methanol. This property is widely used in drug synthesis, material preparation and other fields.
The physicochemical properties of this compound lay the foundation for its application in many fields such as organic synthesis, drug research and development, and materials science. According to its properties, researchers can rationally design reactions and prepare desired compounds.

Methyl 4-bromothiopheno [2,3-c] pyridine-2-carboxylate, when storing and transporting, many matters need to be paid attention to.
The first thing to pay attention to is the storage environment. A cool, dry and well-ventilated place should be selected. Because it may be quite sensitive to temperature and humidity, high temperature is prone to deterioration, and humidity may lead to reactions such as hydrolysis. If placed in a hot place, the molecular structure may be damaged, causing its chemical properties to change; in a humid place, water vapor may interact with ester groups to damage its purity and quality. Therefore, the storage temperature should be controlled within a specific range, such as between 15 ° C and 25 ° C, and the humidity should be maintained at 40% - 60%.
Furthermore, the transportation process should not be ignored. This material needs to be properly packaged to prevent collision and leakage. Because of its certain chemical activity, once it leaks or reacts with external substances, it will not only damage itself, but also endanger the environment and personal safety. Packaging materials must have good compression and impact resistance, and can prevent leakage. Transportation vehicles should also maintain appropriate temperature and humidity to avoid severe turbulence.
In addition, storage and transportation should be kept away from fire sources, heat sources and strong oxidants. Due to its chemical structure characteristics, in case of open flames, hot topics or strong oxidants, there may be a risk of combustion or explosion. Therefore, storage and transportation should not coexist with such substances. And operators need professional training, familiar with operating norms and emergency measures, in the event of an emergency, they can respond quickly and correctly to reduce losses and hazards.