4-Bromo-thieno[2,3-c]pyridine-2-carbonitrile

4-Bromo-thieno [2,3-c] pyridine-2-carbonitrile, Chinese name 4-bromothieno [2,3-c] pyridine-2-formonitrile, this substance has a wide range of uses and has many applications in the field of pharmaceutical and chemical industry.
It can be used as a key intermediate in drug development. The structure of guienthiophene-pyridine is common in many bioactive molecules, and both nitrile and bromine atoms have high reactivity. Nitrile groups can be converted into various functional groups, such as carboxyl groups and amino groups, through various reactions such as hydrolysis and reduction. This is the cornerstone of building complex drug molecular structures. Bromine atoms can participate in nucleophilic substitution, coupling reactions, etc., such as Suzuki coupling, Buchwald-Hartwig coupling, etc., to introduce various organic groups to optimize the activity, solubility and pharmacokinetic properties of drug molecules.
In the field of materials science, 4 - Bromo - thieno [2,3 - c] pyridine - 2 - carbonitrile also has potential. The conjugated structure of thiophenopyridine gives its unique photoelectric properties, which can be used to prepare organic optoelectronic materials, such as Light Organic Emitting Diode (OLED), organic solar cells, etc. By rationally modifying the structure of the molecule, regulating its energy level and charge transport properties, the photoelectric conversion efficiency and stability of the material can be improved.
In addition, in the field of organic synthetic chemistry, as an organic reagent with special structures, it can be used to develop novel synthetic methodologies, providing an effective path for the construction of complex organic molecules containing thiophenopyridine skeletons, and promoting the progress of organic synthetic chemistry.

The synthesis method of 4-bromo-thiopheno [2,3-c] pyridine-2-formonitrile has been known for a long time. There are many methods, and the best ones can be selected according to different raw materials and conditions.
First, thiophenopyridine is used as the starting material. First, thiophenopyridine meets bromine-containing reagents under specific reaction conditions, such as bromine, N-bromosuccinimide (NBS) and the like. This bromination reaction requires careful regulation of reaction temperature, time and reagent dosage to make the bromine atom fall precisely at the fourth position of the target. Subsequently, the bromide product and the cyanogen-containing reagents, such as potassium cyanide, sodium cyanide, etc., under the action of appropriate solvents and catalysts, undergo a nucleophilic substitution reaction to introduce cyanyl groups, and the final result is 4-bromo-thiopheno [2,3-c] pyridine-2-formonitrile.
Second, it can also start from thiophene derivatives containing cyanyl groups. First, the thiophene ring is suitably modified to construct the pyridine ring. The cyclization reaction can be used to gradually tend the molecular structure to the framework of the target product. In this process, the choice of reaction conditions is crucial, such as the selection of suitable bases, solvents and reaction temperatures. After the pyridine ring is formed, the bromination reaction is carried out, and the bromine atom is introduced at the 4 position. This bromination step is similar to the previous one, and each reaction element needs to be carefully controlled.
Third, there is still a way to synthesize the heterocyclic ring construction strategy. Select the appropriate sulfur-containing and nitrogen-containing heterocyclic fragments, and gradually splice them into the skeleton of thiopheno [2,3-c] pyridine through multi-step reaction. During the synthesis process, the timing and manner of the introduction of cyano and bromine atoms are cleverly arranged. For example, the synthesis of 4-bromo-thiopheno [2,3-c] pyridine-2-formonitrile is achieved by first constructing a partial structure containing cyanide groups, and then through a series of reactions such as cyclization and bromination.
Synthesis of this compound requires careful consideration at every step, from the selection of raw materials, the optimization of reaction conditions, to the separation and purification of the product, all of which are related to success or failure. All synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs and experimental conditions.

4-Bromo-thiopheno [2,3-c] pyridine-2-formonitrile, this is an organic compound. Looking at its structure, it contains bromine atoms, thiopheno-pyridine rings and formonitrile groups. This structure gives it unique physical properties.
First of all, its state and color are mostly solid at room temperature and pressure, but due to the difference in purity and crystal form, or there are differences. It is usually a white-like to light-yellow solid, and this color is derived from the light absorption and reflection characteristics of the molecular structure.
The times and melting points, as determined by experiments, are about a certain temperature range. This temperature is crucial for its identification and purity evaluation. The melting point is influenced by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. In this compound, the interaction of various groups makes the molecules arranged in an orderly manner, and the melting point is in a specific range.
The other is solubility. In organic solvents, such as common dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc., it shows a certain solubility. Because these organic solvents can form interactions with compound molecules, such as dipole-dipole interaction, it helps them disperse and dissolve. In water, the solubility is poor. Due to its hydrophobic structure, it is difficult to form an effective force between water molecules and compound molecules, and it is impossible to overcome the intermolecular forces of the compound to disperse.
In terms of its stability, under conventional environmental conditions, it has a certain stability. However, under extreme conditions such as strong acid, strong base or high temperature, some chemical bonds in the molecular structure may be affected. The methonitrile group may be hydrolyzed under strong acid or strong base, and the bromine atom may undergo a substitution reaction under specific conditions.
In addition, the compound has certain biological activities and optical properties due to its nitrogen, sulfur heterocyclic and cyanic groups, and has attracted much attention in the fields of pharmaceutical chemistry, materials science and other fields. In drug development, it may become a lead compound; in the field of materials, or in optoelectronic devices due to its structural properties.

4 - Bromo - thieno [2,3 - c] pyridine - 2 - carbonitrile is an organic compound. Looking at its structure, it contains bromine atoms, thiophenopyridine rings and nitrile groups. The stability of its chemical properties requires detailed investigation of the interaction of various groups.
Bromine atoms have certain reactivity and can participate in nucleophilic substitution reactions. Due to its electronegativity difference, the carbon-bromine bond electron cloud is biased towards bromine, making the carbon atoms partially positively charged and vulnerable to attack by nucleophilic reagents. Under suitable conditions, the bromine atom can be replaced by other groups.
thiophenopyridine rings are conjugated systems and have certain aromatics. This structure imparts certain stability to the compound, and electron delocalization reduces the energy of the system. However, due to the atomic hybridization mode and electron cloud distribution on the ring, the electron cloud density at different positions on the ring is different, which affects the electrophilic substitution reaction activity and check point selectivity.
The carbon-nitrogen triple bond in the nitrile group (-CN) has high bond energy and relatively stable chemical properties. However, the nitrile group can undergo various reactions, such as hydrolysis to carboxylic acid or amide under acid or base catalysis, or participate in nucleophilic addition reactions.
In general, the stability of 4-Bromo-thieno [2,3-c] pyridine-2-carbonitrile is not absolute, and different groups interact with each other. Under mild conditions, it is relatively stable without specific reagents and conditions; but under specific reaction conditions and reagents, each group can participate in the reaction and exhibit chemical activity.

I look at your question, but I am inquiring about the price range of 4 - Bromo - thieno [2,3 - c] pyridine - 2 - carbonitrile in the market. However, this compound is not widely known and common, and its price is affected by many factors, making it difficult to directly state the exact number.
First, the purity of this compound has a great impact on the price. If the purity is very high, it is almost extreme, such as more than 99%, the price will be high. High purity requires exquisite craftsmanship and complicated processes, which consume a lot of manpower and material resources. The cost is high, and the price is expensive. And if the purity is slightly lower, such as about 95%, although it can meet part of the demand, the price may drop significantly compared with high purity.
Second, the purchase volume is also the key. If you buy in bulk, the supplier may be able to reduce its cost due to the large quantity, such as more fully utilized production equipment, lower transportation cost sharing, etc., so as to give discounts and reduce the unit price. On the contrary, only buy a small amount, such as required for small laboratory trials, because you cannot enjoy economies of scale, the supplier's price may be higher.
Third, the source channel has a lot of influence. If you buy from a well-known large factory, its production process is standardized, quality control is strict, product quality is guaranteed, and the price may be high. And if you look for a small factory or an emerging manufacturer, although the price may be slightly lower, the quality may be difficult to compare with that of a large factory.
And the market conditions are changing rapidly, and the rise and fall of raw material prices and changes in supply and demand will cause their prices to fluctuate. Therefore, to know the exact price range, you need to consult the chemical raw material supplier in person, or check the professional chemical product trading platform to get an accurate number.