4-Bromo-pyridine-2-sulfonyl chloride

4-Bromo-pyridine-2-sulfonyl chloride is an important compound in organic chemistry. Its physical properties are quite characteristic.
Looking at its appearance, it is often in the form of white to off-white crystalline powder, which is easy to observe and handle. As for the melting point, it is about a specific range. This property is of great significance in identification and purity judgment. It covers different purity materials, and the melting point is also different.
In terms of solubility, it has a certain solubility in common organic solvents, such as dichloromethane, chloroform, etc. This solubility makes it possible to choose a suitable solvent to help the reaction proceed smoothly in the organic synthesis reaction. However, in water, its solubility is extremely low, which is due to the hydrophobic pyridine ring and sulfonyl chloride group in its molecular structure.
4-Bromo-pyridine-2-sulfonyl chloride is volatile to a certain extent, and attention should be paid to the ventilation environment during operation to prevent the accumulation of harmful gases. And because of the activity of the sulfonyl chloride group, its chemical properties are active, and it is easy to hydrolyze in contact with water. Hydrogen chloride gas will be produced during hydrolysis, so it must be kept in a dry environment during storage to maintain its stability. < Br >
Its density is also an important physical property. Although the exact value needs to be determined experimentally, the approximate range is helpful in practical applications to consider its distribution and mixing in the reaction system.
From the above, it can be seen that the physical properties of 4-bromo-pyridine-2-sulfonyl chloride are diverse, and all properties are interrelated. It is necessary to consider this compound in detail in the fields of organic synthesis and drug development.

The chemical synthesis of 4-bromopyridine-2-sulfonyl chloride is an important topic in the field of organic synthesis. Its synthesis path has been explored by many parties in the past, and each has its own ingenious method.
First, pyridine can be initiated. Pyridine is brominated first, and a suitable brominating reagent, such as liquid bromine, is selected. Under specific reaction conditions, such as the presence of a suitable catalyst, a specific temperature and reaction time, bromine atoms precisely replace hydrogen atoms at specific positions on the pyridine ring to obtain 4-bromopyridine. Subsequently, 4-bromopyridine is used as a substrate to introduce a sulfonyl chloride group. With the help of reagents such as chlorosulfonic acid, the sulfonylation reaction can be achieved through specific reaction steps to generate 4-bromopyridine-2-sulfonyl chloride. In this path, the bromination step needs to pay attention to the reaction selectivity, so that the bromine atom is substituted at the 4 position of the pyridine ring, and the sulfonylation step needs to control the reaction conditions to ensure the successful introduction of the sulfonyl chloride group and the purity of the product.
Second, there are also pyridine derivatives containing specific substituents as starting materials. For example, 4-bromopyridine-2-sulfonyl chloride can be obtained by selecting compounds that have suitable substitutions based on specific positions of the pyridine ring. Through rational design of reaction steps, through a series of conversions such as halogenation and sulfonylation, 4-bromopyridine-2-sulfonyl chloride can be obtained. The key to this approach lies in the selection of starting materials and the early synthesis to ensure the smooth progress of subsequent reactions and the efficient acquisition of the target product.
Furthermore, there is a synthesis strategy using transition metal catalysis. With suitable metal catalysts, such as palladium catalysts, and specific ligands, in a suitable reaction system, the coupling and substitution of substrate molecules can be promoted to achieve the synthesis of 4-bromopyridine-2-sulfonyl chloride. This method requires precise regulation of catalyst dosage, ligand structure and reaction conditions to improve reaction efficiency and selectivity. In short, the synthesis of 4-bromopyridine-2-sulfonyl chloride can be achieved according to different starting materials and reaction strategies. Each method has its own advantages and disadvantages, and the choice needs to be weighed according to actual needs and conditions.

4-Bromo-pyridine-2-sulfonyl chloride is widely used in organic synthesis. This compound can be used as a key intermediate and is involved in many organic reactions.
First, in the nucleophilic substitution reaction, the chlorine atom has high activity and is easily replaced by nucleophilic reagents. If it meets with alcohols, it can form a corresponding sulfonate. This sulfonate is mostly used as a leaving group in organic synthesis to help build carbon-carbon bonds, carbon-heteroaryl bonds, etc., to lay the foundation for the synthesis of complex organic molecules.
Second, it can also react with amine compounds, sulfonamides. Sulfonamide plays an important role in the field of medicinal chemistry, and many drug molecules contain this structure, which can change the physical, chemical and biological activities of compounds and provide opportunities for the creation of new drugs.
Furthermore, when constructing compounds containing pyridine rings, 4-bromo-pyridine-2-sulfonyl chloride also exhibits its capabilities. Bromine atoms can be coupled with various organoboronic acids and organotin reagents through metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc., so as to expand the substitution mode of pyridine rings and synthesize pyridine derivatives with diverse structures and specific functions.
In addition, due to the coexistence of pyridine ring and sulfonyl chloride, it can be modified by a series of reactions to regulate the distribution of molecular electron clouds and the spatial structure, and has potential application value in the preparation of organic materials with special photoelectric properties in materials science. In short, the use of 4-bromo-pyridine-2-sulfonyl chloride in organic synthesis provides many possibilities for chemical research and related industrial development.

4-Bromo-pyridine-2-sulfonyl chloride is a chemical substance. The conditions for its storage are most important. It is active and easy to change in contact with water, heat, light, etc.
When storing, the first thing to do is to avoid water. Because it will quickly dissolve in contact with water, it will lose its properties. Therefore, it must be placed in a dry place and stored in a sealed container to prevent moisture from entering. The container is preferably made of glass or stainless steel, because it does not react with the material and maintains its purity.
It is better to avoid heat. High temperature can promote its decomposition or other reactions, and damage its quality. It should be stored in a cool place with a temperature not exceeding 25 ° C. And it should also be protected from light, light or photochemical reaction, and its structure should be changed.
In addition, this material is corrosive and toxic, and it must be protected when stored. The storage area must be well connected to prevent the accumulation of gas. And it should be isolated from other objects, avoiding alkali, alcohol, etc.
In short, the storage of 4-bromo-pyridine-2-sulfonyl chloride must be dry, cool, and dark, and good protection and isolation, so as to protect its quality and avoid risk.

4-Bromo-pyridine-2-sulfonyl chloride, the price of this product in the market is difficult to determine. The change in its price is affected by many factors.
The first to bear the brunt is the price of raw materials. If the price of the raw materials required for the preparation of 4-bromo-pyridine-2-sulfonyl chloride, such as specific bromides, pyridine derivatives and sulfonation reagents, rises and falls sharply, the price of 4-bromo-pyridine-2-sulfonyl chloride will also change accordingly. If the production of raw materials at the origin of the raw material decreases sharply, or due to natural or man-made disasters, the price of the raw material will rise, and the price of the chlorine will also rise.
Furthermore, the simplicity and cost of the preparation process are also key. If the preparation requires high-end equipment, harsh reaction conditions, such as high temperature, high pressure, specific catalysts, etc., and the catalyst is expensive or difficult to prepare, or the reaction steps are numerous and time-consuming, this will greatly increase the production cost, resulting in high market prices.
The supply and demand relationship in the market also affects its price. If many industries, such as medicine, pesticides, etc., have strong demand for 4-bromo-pyridine-2-sulfonyl chloride, but the supply is relatively insufficient, its price will rise; on the contrary, if the market demand is sluggish and the manufacturer's inventory is overstocked, in order to recover funds, prices may be reduced and promoted.
In addition, differences in regions also make prices different. In places where the chemical industry is concentrated, the price may be lower than elsewhere due to the convenience of production and low logistics costs; in remote places, the price may vary due to high transportation costs and different supply and demand relationships.
From this perspective, in order to know the exact market price of 4-bromo-pyridine-2-sulfonyl chloride, it is necessary to carefully investigate the fluctuation of raw material prices, the cost of preparation processes, market supply and demand, and regional factors, etc., in order to obtain a more accurate price.