4-Bromo-pyridine-2-carboxylic acid methyl ester

Methyl 4-bromo-pyridine-2-carboxylate is widely used. In the field of pharmaceutical synthesis, it is often a key intermediate. The structure of genopyridine and methyl carboxylate gives it unique chemical activity, which can interact with various reagents through various chemical reactions to construct complex drug molecular structures. For example, when developing specific antimalarial drugs, methyl 4-bromo-pyridine-2-carboxylate acts as an important starting material. After multiple steps of delicate reactions, compounds with specific biological activities can be obtained, which are expected to become effective drugs for the treatment of malaria.
In the field of materials science, it also has extraordinary performance. Due to the presence of bromine atoms, they can participate in many polymerization reactions, thereby preparing polymer materials with unique properties. For example, when preparing polymers with special optical or electrical properties, methyl 4-bromo-pyridine-2-carboxylate can be introduced as a functional monomer, which in turn allows polymer materials to exhibit special properties such as photochromic and electrical conductivity, injecting new vitality into the development of materials science.
In addition, methyl 4-bromo-pyridine-2-carboxylate is also a commonly used reagent in organic synthetic chemistry research. Chemists can take advantage of its bromine atom's susceptibility to nucleophilic substitution reactions to react with various nucleophilic reagents to achieve functionalization on pyridine rings, providing a convenient way for the synthesis of novel organic compounds and promoting the innovative development of organic synthetic chemistry.

The synthesis method of 4-bromopyridine-2-carboxylic acid methyl ester is not detailed in the ancient book "Tiangong Kaiwu", but it can be deduced according to the current chemical principles and methods.
First, 4-bromopyridine-2-carboxylic acid is used as the starting material to esterify it with methanol in the presence of a catalyst. Sulfuric acid can be one of the commonly used catalysts, but it is highly corrosive, and the operation needs to be cautious. During the reaction, put the two in the reaction vessel, drop an appropriate amount of sulfuric acid, and heat to maintain a certain temperature to make the reaction fully proceed. This process needs to be controlled by temperature. If it is too high, side reactions will increase, and if it is too low, the reaction rate will be slow.
Second, with 2-methyl-4-bromopyridine as the starting material, 4-bromopyridine-2-carboxylic acid is obtained first through oxidation reaction, and then esterified with methanol as described above. During the oxidation process, suitable oxidants such as potassium permanganate can be selected. However, potassium permanganate has strong oxidation, and the reaction conditions need to be precisely regulated, otherwise the product is impure.
Third, it can also be prepared from pyridine through multi-step reaction. Bromine atoms are introduced at specific positions of pyridine first, then carboxyl groups are introduced, and finally esterified to obtain the target product. Although this route is complicated, it can be optimized according to the reaction conditions of each step to improve the purity and yield of the product. Each step of the reaction requires fine operation, and factors such as reaction conditions and the proportion of reactants are carefully considered to obtain better results.

Methyl 4-bromopyridine-2-carboxylate, this is an organic compound with unique physical properties. Its shape is colorless to pale yellow liquid or crystalline solid, depending on the temperature and environment. Under normal temperature and pressure, it is mostly stable.
Looking at its melting point, the melting point is about 45-48 ° C. This property makes it a solid-to-liquid transition in a specific temperature range. The boiling point is roughly in the range of 260-265 ° C, indicating that a higher temperature is required to convert it from liquid to gas.
In terms of solubility, the substance is insoluble in water, because the molecular structure contains hydrophobic pyridine rings and bromine atoms, and the interaction between water molecules is weak. However, it is soluble in common organic solvents, such as ethanol, ether, chloroform, etc., because these organic solvents can form similar intermolecular forces with 4-bromopyridine-2-carboxylate methyl ester molecules, following the principle of "similar miscibility".
Its density is about 1.57 g/³ cm, which is larger than the density of water at 1 g/cm ³, so if mixed with water, it will sink to the bottom of the water.
In addition, methyl 4-bromopyridine-2-carboxylate has a certain volatility and will slowly evaporate into the air in an open environment. However, its volatilization rate is relatively slow, and there is a certain interaction force between molecules that prevents molecules from escaping from the liquid phase. And because it is an organic halide, steam or smoke is irritating to a certain extent. Pay attention to ventilation during operation to prevent damage to the human respiratory tract and eyes.

4-Bromo-pyridine-2-carboxylic acid methyl ester, the price of this product is variable in the market, and it mostly varies due to various circumstances.
Looking at the market conditions of chemical products in the past, the price of raw materials depends on their selling price. If the price of bromine, pyridine and other raw materials required for its preparation is high, or the output varies due to changes in time and place of origin, or there are many seekers in the market, this can make the price of raw materials rise, and then the price of 4-bromo-pyridine-2-carboxylic acid methyl ester also rises.
Furthermore, the preparation method is also related. If the method is complicated, requires many steps, consumes man-hours and material resources, and requires strict equipment and skills, the yield will also affect the cost. Therefore, if the method with convenient preparation and good yield is widely used, the price may stabilize or decrease; on the contrary, the price will easily rise.
The trend of market supply and demand is particularly critical. For example, the demand for this product in the pharmaceutical, chemical and other industries has increased greatly, but the supply is not enough, and the price will rise; if the supply exceeds the demand, merchants will sell their goods or compete to reduce the price.
The difference in regions also makes the price different. In distant places, the difference in transportation fees and taxes can cause the same product to have different prices in different places.
In summary, in order to know the current exact market price of methyl 4-bromo-pyridine-2-carboxylate, it is necessary to carefully investigate various factors such as the status of raw materials, preparation methods, supply and demand conditions, and regional differences. Real-time visits to chemical markets and merchants are required to obtain a more accurate price.

4-Bromopyridine-2-carboxylic acid methyl ester, when storing and transporting, pay attention to many matters. This is an organic compound with more active properties.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. Cover because of its high temperature, or chemical properties change, or even cause decomposition and other adverse reactions. Humid environment should also be avoided, because it may interact with water vapor, resulting in damage to quality.
Furthermore, it must be kept away from fire and heat sources. The compound is flammable, and it is easy to burn in case of open flames and hot topics. Therefore, fireworks are strictly prohibited in storage places, and corresponding fire protection facilities should be equipped. And because it is sensitive to light, it should be stored away from light. It can be placed in a brown bottle or in an opaque container to prevent light from promoting photochemical reactions and affecting its purity and stability.
When transporting, caution is also required. The integrity of the container should be ensured to prevent leakage. If this compound leaks or pollutes the environment, it will pose a hazard to transporters. The transportation vehicle is also selected to have fire protection and explosion protection functions, and it must be driven at a constant speed during transportation to avoid violent actions such as sudden braking and sharp turning to prevent package damage due to collision.
In addition, transportation and storage personnel should be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident such as a leak, effective measures should be taken promptly, such as evacuating crowds, sealing off the scene, and using appropriate materials to absorb leaks, etc., to reduce harm.