4-Bromo-pyridine-2-carboxylic acid ethyl ester

Ethyl 4-bromo-pyridine-2-carboxylate is a crucial compound in organic synthesis and has a wide range of uses in many fields.
First, in the field of medicinal chemistry, it can be said to be a key intermediate for the construction of many drug molecules. With the unique chemical activity of the pyridine ring with bromine atoms and ester groups, chemists can skillfully modify and derive it. Through carefully designed reactions, specific pharmacoactive groups can be introduced into it to synthesize drugs with unique pharmacological activities. For example, in the development of small molecule inhibitors targeting specific disease targets, ethyl 4-bromo-pyridine-2-carboxylate can be used as a starting material to construct a drug molecular structure that precisely binds to the target through multi-step reactions, paving the way for the development of new drugs.
Second, in the field of materials science, it also plays a role that cannot be ignored. Using its chemical structure characteristics, it can participate in the preparation of functional materials. The presence of pyridine rings gives it certain electronic properties, while bromine atoms and ester groups provide the possibility for further reactions. By reacting with other organic or inorganic compounds, materials with special optical and electrical properties can be prepared, such as organic Light Emitting Diode (OLED) materials, which inject new vitality into the development of materials science.
Third, in the field of fine chemicals, 4-bromo-pyridine-2-carboxylate ethyl ester is often used in the synthesis of various fine chemicals. Such as special fragrances, additives, etc. Due to its unique chemical structure, after specific chemical reactions, it can generate substances with unique odors or properties, meeting the needs of the fine chemical industry for product diversification and high performance.
To sum up, ethyl 4-bromo-pyridine-2-carboxylate plays a crucial role in many fields such as medicinal chemistry, materials science, and fine chemistry due to its unique chemical structure and activity, and plays a crucial role in promoting the development of various fields.

There are several methods for the synthesis of 4-bromopyridine-2-carboxylic acid ethyl ester. One method can also start from 4-bromopyridine-2-carboxylic acid and make it co-heat with ethanol under acid catalysis to carry out esterification reaction. Among them, commonly used acid catalysts, such as concentrated sulfuric acid and p-toluenesulfonic acid, etc. During the reaction, attention should be paid to the control of temperature. Generally, it is carried out at an appropriate reflux temperature to make the reaction complete. After the reaction is completed, the product is extracted with an appropriate organic solvent, and then the pure 4-bromopyridine-2-carboxylic acid ethyl ester can be obtained through various post-processing steps such as washing, drying, and distillation.
Another method is to use pyridine as the starting material and brominate to obtain 4-bromopyridine. Then, 4-bromopyridine and carbon dioxide are carboxylated under specific conditions, such as high pressure and the presence of suitable catalysts, to obtain 4-bromopyridine-2-carboxylic acid. Finally, as in the previous method, it is esterified with ethanol to obtain the target product. In this approach, the conditions of the bromination reaction need to be carefully selected to ensure that the bromine atom is accurately introduced into the fourth position of the pyridine ring. During the carboxylation reaction, the pressure of carbon dioxide, the type and amount of catalyst have a significant impact on the efficiency and selectivity of the reaction.
Furthermore, there are also methods for gradually constructing target molecules by taking other compounds containing pyridine structures as starting materials and transforming them through a series of functional groups. However, such methods often have many steps, and the reaction routes need to be carefully planned, and the feasibility and yield of each step of the reaction should be considered before the effective synthesis of ethyl 4-bromopyridine-2-carboxylate.

Ethyl 4-bromopyridine-2-carboxylate is one of the organic compounds. Its physicochemical properties are very important and are related to many chemical applications.
Looking at its physical properties, at room temperature, this compound is mostly solid, or white to light yellow crystalline powder, which is caused by the force between molecules. Its melting point is also a key physical property, roughly within a specific temperature range, which is determined by the regularity of the molecular structure and the strength of the interaction. The determination of the melting point can provide the basis for identification and purity judgment.
When it comes to solubility, ethyl 4-bromopyridine-2-carboxylate exhibits a certain solubility in organic solvents such as ethanol, ether, chloroform, etc. This is because the molecular structure of the compound contains polar and non-polar parts, and can form van der Waals forces or hydrogen bonds with organic solvent molecules. However, the solubility in water is relatively limited, and its polarity is not enough to overcome the strong hydrogen bonds between water molecules.
In terms of its chemical properties, bromine atoms give the compound active chemical activity. Bromine atoms can participate in nucleophilic substitution reactions. If they react with nucleophiles, such as alkoxides and amines, bromine atoms can be replaced to form new carbon-heteroatom bonds, providing a path for the synthesis of more complex organic compounds. At the same time, ester groups are also reactive and can undergo hydrolysis under the catalysis of acids or bases. Hydrolyzed under acidic conditions, 4-bromopyridine-2-carboxylic acid and ethanol can be obtained; under alkaline conditions, hydrolysis is more thorough and rapid, resulting in carboxylate and ethanol. This hydrolysis reaction is widely used in the fields of organic synthesis and medicinal chemistry. In addition, the electron cloud distribution characteristics of the pyridine ring enable the compound to participate in various electrophilic substitution reactions. Under appropriate conditions, other functional groups can be introduced into the pyridine ring to further expand the possibility of its chemical derivation, laying the foundation for the creation of new functional materials or bioactive molecules.

4-Bromopyridine-2-carboxylate ethyl ester is on the market, and its price range is difficult to determine. The price of this compound often varies due to many factors.
First, it is about purity. If the purity is extremely high and almost flawless, such as reaching the high purity level used in chemical analysis, and there are very few impurities, the price of such a good product is high. Because of its preparation process, it requires fine craftsmanship and multiple purification, which consumes huge manpower, material resources and financial resources. On the contrary, if the purity is slightly lower, it is only suitable for general basic experiments, and the impurities contained in specific reactions are fine, then the price should be relatively easy.
Second, the yield is also the key. If the market demand is large and the producer produces a large amount of output, according to the principle of supply and demand in economics, the unit cost may be reduced due to the scale effect, and the price may become more affordable. However, if the demand is thin and the output is limited, the preparation cost will be higher after apportioning, and the price will rise.
Third, the price of raw materials also has an impact. The synthesis of 4-bromopyridine-2-ethyl carboxylate requires specific raw materials. If the raw materials are easily available and the price is low, the cost will also be low, and the selling price may drop. On the contrary, if the raw materials are scarce and difficult to obtain, the price will be high, resulting in the price of the compound also rising.
Fourth, different supplier strategies are different. Large merchants may price slightly higher due to their advantages in brand, service, and after-sales; while small merchants compete for the market or adopt low-price strategies.
To sum up, in common market transactions, the price of 4-bromopyridine-2-ethyl carboxylate per gram may range from tens to hundreds of yuan. However, this is only a rough estimate. The actual price needs to be consulted with various suppliers and compared with quotations in different periods to obtain a more accurate figure.

Ethyl 4-bromo-pyridine-2-carboxylate, this is an organic compound, and its storage conditions are very critical.
It should be placed in a cool place, because it is easy to change its chemical properties due to high temperature. During the summer heat, if exposed to the hot sun, the temperature rises, or the molecular structure changes, causing it to deteriorate. And should be stored in a dry place, away from humid environment. Because moisture may react with the compound, or accelerate its decomposition. For example, during the rainy season in the south, the air humidity is high, and if it is not stored properly, the compound may be affected.
Furthermore, it should be stored in a well-ventilated place. If the ventilation is not good, the volatile gas of the compound will accumulate, or the local concentration will be too high, which may pose a safety hazard and affect its own stability.
This compound has certain chemical activity and should be stored away from fire sources, oxidants, etc. Fire sources can easily cause combustion, and oxidants may react violently with it, causing danger. And it needs to be placed separately from other chemicals to avoid interaction.
After taking it, the container should be sealed in time to prevent air, moisture, etc. from entering to ensure its chemical stability, so that it can maintain its due properties and efficacy during subsequent use.