4-Bromo-pyridine-2-carbonitrile

4-Bromopyridine-2-formonitrile, this is an organic compound. Its chemical properties are unique and it has a wide range of uses in the field of organic synthesis.
In terms of its nucleophilic substitution reaction characteristics, bromine atoms are highly active and vulnerable to attack by nucleophilic reagents to achieve functional group conversion. For example, in an alkaline environment, nucleophilic reagents such as alkoxides and amines can react with bromine atoms to form new carbon-heteroatom bonds, laying the foundation for the construction of diverse organic molecular structures.
Talking about its hydrolysis reaction, under the catalysis of acids or bases, cyano groups can be hydrolyzed to form amides and then converted into carboxylic acids. This process is of great significance in the preparation of carboxyl or amido pyridine derivatives, which can introduce key functional groups and expand the application scope of compounds.
4-bromopyridine-2-formonitrile also has certain reduction reactivity. Under specific reduction conditions, the pyridine ring can be partially reduced, adjusting the electron cloud distribution and spatial structure of the molecule, thereby changing the physical and chemical properties of the compound to meet different synthesis needs.
In addition, the bromine atom of this compound is active in metal-catalyzed coupling reactions, such as Suzuki coupling and Stille coupling, which can be coupled with various organoboronic acids or organotin reagents to realize the construction of carbon-carbon bonds of pyridine rings, assist in the synthesis of complex organic conjugated systems, and play an important role in pharmaceutical chemistry, materials science, and other fields.

4-Bromopyridine-2-formonitrile is also an important intermediate in organic synthesis. The common synthesis methods are about a few.
First, pyridine is used as the starting material. Cyanyl is introduced first at the 2-position of pyridine, and bromine atoms are introduced at the 4-position later. If pyridine is used with cyanide reagents, such as cuprous cyanide, under suitable reaction conditions, cyanyl can be successfully introduced at the 2-position to obtain pyridine-2-formonitrile. Subsequently, a suitable brominating reagent, such as N-bromosuccinimide (NBS), is selected, and the reaction is heated in a suitable solvent under the action of an initiator such as benzoyl peroxide, so that the bromine atom replaces the hydrogen atom at the 4-position of pyridine-2-formonitrile, and 4-bromopyridine-2-formonitrile can be obtained. In this path, the cyanidation reaction needs to pay attention to the control of the reaction conditions to ensure the selectivity of cyano introduction; the bromination reaction should pay attention to the amount of brominating reagent and the reaction temperature to prevent the formation of polybrominated products.
Second, 2-aminopyridine can also be used as the starting material. First, 2-aminopyridine is subjected to diazotization reaction, which is treated with sodium nitrite and inorganic acids such as hydrochloric acid to generate diazonium salts. Subsequently, the diazonium salt is reacted with a mixed system of cuprous cyanide and potassium cyanide, and the diazonium group can be converted into cyano to obtain pyridine-2-formonitrile. After that, according to the above bromination method, pyridine-2-formonitrile is brominated with brominating reagents such as NBS to obtain the target product. In this way, the diazotization reaction needs to be strictly controlled at the reaction temperature, usually at low temperature, to avoid the decomposition of the diazonium salt and affect the reaction yield.
Third, 4-bromopyridine can also be used. First, the 2-position of 4-bromopyridine is introduced into the functional group through a suitable method, and then converted to cyano. For example, 4-bromopyridine reacts with metal-organic reagents such as butyl lithium to generate the corresponding lithium reagent, and then reacts with cyanylating reagents such as ethyl cyanoformate. After subsequent steps such as hydrolysis, the 2-position functional group can be converted into a cyano group, and 4-bromopyridine-2-formonitrile is finally obtained. In this process, the reactivity of metal-organic reagents is high, and it needs to be operated under anhydrous and oxygen-free conditions, and attention should be paid to the proportion of reaction substrates and the control of reaction time.

4-Bromopyridine-2-formonitrile is useful in many fields. In the field of medicine, this compound is often a key raw material for the creation of new drugs. Due to its unique chemical structure, it can play an important role in the design of drug molecules, assisting in the synthesis of molecules with specific biological activities, or for targeted therapeutic drugs, or for antibacterial and antiviral agents. Through the interaction of its structure with biological targets, it can achieve the purpose of treating diseases.
In the field of materials science, 4-bromopyridine-2-formonitrile also has a place. It can be used to prepare functional materials, such as optoelectronic materials. Its structural properties endow the material with unique optical and electrical properties, and can be applied to organic Light Emitting Diode (OLED), solar cells and other devices to help improve their performance, optimize photoelectric conversion efficiency, and contribute to the research and development of new materials.
Furthermore, in the field of organic synthetic chemistry, 4-bromopyridine-2-formonitrile is an important synthetic intermediate. Chemists can use its bromine atom and cyanyl activity to carry out various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct more complex organic molecular structures, enrich the variety of organic compounds, and promote the development and progress of organic synthetic chemistry.
This compound has shown important application value in the fields of medicine, materials science, and organic synthetic chemistry, providing strong support for research and innovation in various fields.

4-Bromo-pyridine-2-carbonitrile, Chinese name 4-bromopyridine-2-formonitrile, is an important intermediate commonly used in organic synthesis and is widely used in the fields of medicine, pesticides and materials. However, its market price often changes due to various factors.
The first to bear the brunt is the cost of raw materials. The price fluctuations of the starting materials required for the synthesis of 4-bromopyridine-2-formonitrile, such as pyridine compounds, brominating reagents and cyanide reagents, directly affect the cost of the target product. If the supply of raw materials is in short supply or the market demand surges, causing its price to rise, the production cost of 4-bromopyridine-2-formonitrile will also rise, which will then push up the market price.
The production process is also crucial. Advanced and efficient production processes can improve product yield, reduce energy consumption and reduce waste output, thereby reducing production costs. On the contrary, if the production process is backward, not only will the yield be low, but also energy consumption and waste disposal costs will be high, and product prices will naturally remain high.
The relationship between market supply and demand is even more critical. If the market demand for 4-bromopyridine-2-formonitrile is strong, but the supply is relatively insufficient, the price is bound to rise; conversely, if the market is oversupplied, companies may reduce prices for sales.
Furthermore, regional differences also have an impact. Production costs, transportation costs and market competition in different regions vary, resulting in different product prices. Generally speaking, economically developed regions have higher labor costs and operating costs, and product prices may be slightly higher than in other regions.
To know the exact market price, you can go through the following channels. First, consult professional chemical product suppliers, such as search banner, Tixiai and other well-known reagent companies, whose official websites or sales representatives can provide detailed price information. Second, pay attention to the chemical product trading platform, which gathers quotations from many suppliers and can intuitively understand the market price range. Third, participate in chemical industry exhibitions and seminars, communicate with industry insiders, and obtain first-hand price information.
It can be seen from the above that the market price of 4-bromopyridine-2-formonitrile is affected by many factors such as raw material costs, production processes, supply and demand relationships, and regional differences. Real-time prices need to be inquired through multiple channels to know.

4-Bromo-pyridine-2-formonitrile is also an organic compound. The storage conditions are particular about the stability and safety of this compound.
This compound should be stored in a cool, dry and well-ventilated place. If it is cool, it can avoid the disturbance of high temperature. High temperature often causes the internal structure of the compound to turbulence, or causes adverse reactions such as decomposition and polymerization, which damages its purity and quality. If exposed to hot sun, or near high temperature equipment, it is afraid of accidents.
Dry environment is also key. Moisture in the air can chemically react with many compounds. 4-Bromo-pyridine-2-formonitrile encounters water, or hydrolyzes and changes its properties, so moisture prevention should not be ignored. If you place a desiccant in a storage place, or choose a dry place for storage, it is a good strategy.
Well ventilated, can make the air flow smoothly. If the compound volatilizes harmful gases, or generates undesirable gases due to some reactions, ventilation can make it escape, avoid its accumulation and cause danger, and also ensure the safety of the storage environment.
And keep away from fire and heat sources. Open flames and hot topics are the enemies of compound stability, easy to lead to combustion and explosion. In the storage area, fireworks are strictly prohibited, and electrical equipment must also meet safety standards to prevent accidents caused by electric sparks.
At the same time, this material should be stored separately from oxidants, acids, alkalis, etc. Due to the contact or violent reaction of substances of different chemical properties. The strong oxidation of oxidants and the corrosiveness of acids and bases may cause uncontrollable changes in 4-bromo-pyridine-2-formonitrile, so it is stored in categories to ensure its stability.
When storing, the packaging should also be in good condition. Strong and sealed packaging can prevent compound leakage and prevent external factors from intruding. If the packaging is damaged, moisture, air, etc. are easy to enter and cause compound deterioration.
In short, 4-bromo-pyridine-2-formonitrile should be stored in a cool, dry and ventilated place, away from fire and heat sources, separated from different substances, and packaged in good condition to ensure its quality and safety.