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What are the chemical properties of 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine
4-Bromo-7-methoxy-1H-pyrrolido [2,3-c] pyridine, this is an organic compound. Its chemical properties are unique, let me tell them one by one.
First talk about its physical properties, usually solid, but its specific melting point and boiling point are difficult to say precisely because there is no exact experimental data. However, according to its structure, its melting point may not be too low, because there is a certain force between molecules.
Look at its chemical properties again. Bromine atom is one of its active checking points. Bromine has strong electronegativity, which makes the carbon-bromine bond attached to it quite polar. This property makes the compound prone to nucleophilic substitution reactions. For example, in the presence of suitable bases and nucleophilic reagents, bromine atoms can be replaced by other groups, such as hydroxyl groups, amino groups, etc.
Methoxy groups also affect the properties of the compound. Methoxy groups act as power supply groups, which can increase the electron cloud density of pyridine rings and pyrrole rings, making the rings more electron-rich. This enhances the activity of the compound to undergo electrophilic substitution reactions, and electrophilic reagents are more likely to attack specific positions on the ring. For example, under suitable conditions, electrophilic substitution reactions such as halogenation, nitration, and sulfonation can occur.
At the same time, the pyridine ring and pyrrole ring in this compound are conjugated to each other to form a large conjugated system, which has a great impact on its stability and electron delocalization. The large conjugated system not only stabilizes the molecular structure, but also changes the electron distribution of the molecule, which in turn affects its spectral properties and chemical reactivity.
In addition, the nitrogen atom in this compound has lone pair electrons, which can be used as a ligand to coordinate with metal ions to form complexes, which may have potential applications in the fields of catalysis and materials science.
In conclusion, 4-bromo-7-methoxy-1H-pyrrolido [2,3-c] pyridine is rich in chemical properties and may have broad application prospects in organic synthesis, medicinal chemistry and other fields. However, many properties still need to be further confirmed and further explored by experiments.
What are the main uses of 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine
4-Bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine is one of the organic compounds. It has a wide range of uses and is described below.
In the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can be modified by various chemical reactions to synthesize biologically active drug molecules. For example, when developing drugs for the treatment of specific diseases, different functional groups can be introduced through structural modification to adjust the interaction between the drug and the biological target, enhance the efficacy and reduce side effects. This process is like a skilled craftsman carving beautiful jade, carefully designing and constructing the structure of drug molecules.
In the field of materials science, 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine is also used. It can participate in the preparation of materials with special photoelectric properties. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, the structural properties of the compound can affect the key properties such as luminous efficiency and stability of the material. If it is properly integrated into the material molecular system, it may make the OLED screen show more brilliant colors and lower energy consumption, just like adding a unique touch of brilliance to the material world.
Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can build more complex organic molecular structures based on various reactions, such as nucleophilic substitution, coupling reactions, etc. This is like building blocks. Using this compound as the basic unit, organic compounds with complex structures and different functions can be constructed, providing rich materials and possibilities for the development of organic synthetic chemistry.
In short, 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine has important value in many fields such as medicine, materials and organic synthesis, and is like a shining star, illuminating the research and application path in many chemical-related fields.
What is the synthesis method of 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine
4-Bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine is an important organic compound, and its synthesis method is as follows.
Pyridine or pyrrole derivatives with suitable substituents are often selected as starting materials. Taking methoxy-containing pyridine derivatives as an example, bromine atoms can be introduced at specific positions in the pyridine ring first. This bromination step usually uses liquid bromine or N-bromosuccinimide (NBS) as the bromine source, in a suitable solvent such as dichloromethane or carbon tetrachloride, under the action of light or a free radical initiator (such as azobisisobutyronitrile AIBN), the bromine atom selectively replaces the hydrogen atom at the target position on the pyridine ring to obtain a pyridine intermediate containing bromine and methoxy.
Then, this intermediate is reacted with a pyrrole-containing reagent to construct a pyrrolido-pyridine skeleton. This reaction usually needs to be carried out under the catalysis of a base, and the base can be selected from potassium carbonate, sodium carbonate, etc. Polar aprotic solvents such as dimethylformamide (DMF) or dimethylsulfoxide (DMSO) can be selected as the reaction solvent to promote the nucleophilic substitution reaction. During this process, the activity check point of the pyrrole structure reagent carries out nucleophilic attack on the specific position of the pyridine ring, and undergoes a cyclization reaction to form the basic skeleton of 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine. After the
reaction is completed, the product needs to be isolated and purified. Commonly used methods include column chromatography, using silica gel as the stationary phase, selecting a suitable eluent such as petroleum ether and ethyl acetate mixed solvent, and separating the product from the reaction mixture according to the difference in the partition coefficient between the product and impurities in the stationary phase and the mobile phase to obtain a pure 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine. The whole synthesis process needs to pay attention to the precise control of reaction conditions, including temperature, reaction time, reagent dosage, etc., to achieve the ideal yield and purity.
What is the price range of 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine in the market?
Wuwei Wen 4 - bromo - 7 - methoxy - 1H - pyrrolo [2,3 - c] pyridine is priced on the market. This is a fine chemical, and its price often varies depending on many factors.
First, the purity has a great impact. If the purity is very high, almost 100%, the preparation is difficult, the cost is high, and the price must be high; if the purity is slightly lower, it can be used for general experimental research, and the price may be slightly reduced.
Second, the production scale also plays a role. Large-scale production, due to the scale effect, the unit cost is reduced, and the price is close to the people; small-scale preparation, the cost is high, and the price is high.
Third, the market supply and demand relationship is the key. If there are many people who ask for it, but there are few people who supply it, the price will rise; if the market demand is small and the supply is large, the price will decline.
Fourth, the source and channel are different, and the price is also different. Purchased from a well-known large factory, the quality is guaranteed, and the price may be high; from a small factory or an informal channel, the price may be low, but the quality is unpredictable.
To know the exact price range, you can consult the chemical product supplier, or check it on the chemical product trading platform, and you can get a more accurate price.
4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine is safe and stable
4-Bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine is an organic compound. When it comes to the safety and stability of this compound, it should be analyzed in detail from various angles.
First of all, the stability of this compound is given by the skeleton of pyrrolido-pyridine. However, the presence of bromine atoms and methoxy groups also affects its stability. Although bromine atoms are relatively stable, under certain conditions, such as strong alkaline environment or high temperature and the presence of nucleophiles, nucleophilic substitution reactions can occur, resulting in changes in its structure. The electron cloud density distribution of the pyridine ring and pyrrole ring is affected by the electron effect of the methoxy group. In some chemical reaction scenarios, it can change the reaction activity and direction, and then have an effect on the overall stability.
Once again on safety, in terms of toxicology, there is no detailed data to determine the exact toxicity of the organism. However, organohalides often have potential toxicity, and bromine atoms may participate in the metabolic process in organisms, which will have adverse effects on organisms. In the environment, if this compound enters water or soil, its structure is relatively complex, it is difficult to degrade or accumulate, and then it will affect the ecosystem. When handling this compound, its exact toxicity is unknown. Necessary protective measures should be taken, such as handling in a well-ventilated place, avoiding direct contact with the skin and inhalation, to prevent potential hazards.
In conclusion, the stability of 4-bromo-7-methoxy-1H-pyrrolo [2,3-c] pyridine may vary under specific conditions. Due to the lack of detailed research on safety, caution should be taken when handling and using it to prevent adverse consequences to organisms and the environment.