4-BROMO-6-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

4-Bromo-6-trifluoromethyl-pyridine-2-carboxylate ethyl ester has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help create new drugs. Due to its unique chemical structure, it can introduce specific functional groups through various chemical reactions to build molecular structures with biological activity, which is of great significance for the development of antibacterial, antiviral, anti-tumor and other drugs.
In the field of materials science, it also has its uses. By participating in polymerization reactions or modifying the surface of materials, it endows materials with specific properties such as corrosion resistance, wear resistance, and low surface energy. For example, polymer materials modified by this compound may exhibit excellent chemical stability and surface properties, which are very useful in industries such as aerospace and automobile manufacturing that require strict material properties.
Furthermore, in the field of organic synthetic chemistry, it is an important building block for the synthesis of complex organic molecules. With its structural characteristics, it can carry out a variety of reactions such as nucleophilic substitution and coupling, providing an effective path for the construction of various organic compounds, promoting the development of organic synthetic chemistry, and expanding the variety and application range of organic compounds. In short, 4-bromo-6-trifluoromethyl-pyridine-2-carboxylate ethyl ester plays a key role in many fields and has made great contributions to scientific and technological progress and industrial development.

The synthesis method of ethyl 4-bromo-6-trifluoromethyl pyridine-2-carboxylate is an important research in the field of organic synthesis. There are many methods, the following are common ones.
First, the compound containing the pyridine structure is used as the starting material. The bromine atom is introduced at a specific position in the pyridine ring first, which can be achieved by electrophilic substitution reaction. Select a suitable brominating reagent, such as bromine (Br ²), under appropriate reaction conditions, such as the presence of a catalyst (such as iron powder or iron tribromide) and a specific temperature environment, so that the bromine atom falls precisely at the desired position in the pyridine ring.
Then, trifluoromethyl is introduced. Common reagents such as trifluoromethylation reagents (such as Togni reagent, Umemoto reagent, etc.) successfully connect trifluoromethyl to the pyridine ring by means of nucleophilic substitution or free radical reaction mechanism. This step requires careful regulation of reaction conditions to ensure reaction selectivity and yield.
Furthermore, construct a carboxylic acid ethyl ester group. The corresponding carboxylic acid can be prepared first, such as oxidizing the specific side chain on the pyridine ring with an appropriate oxidizing agent to form a carboxyl group. Subsequently, the carboxylic acid and ethanol are esterified under concentrated sulfuric acid catalysis under heated reflux conditions to generate the target 4-bromo-6-trifluoromethylpyridine-2-carboxylic acid ethyl ester.
Second, it can also start from simple raw materials and build a pyridine ring through multi-step reaction. First, a small molecule containing bromine and trifluoromethyl is used to construct part of the structure of the pyridine ring, and then cyclized to form a pyridine ring. Subsequent to the method described above, the substituents on the pyridine ring are modified to form ethyl carboxylate.
When synthesizing this compound, the reaction conditions at each step need to be carefully regulated, including reaction temperature, reaction time, proportion of reactants and catalyst dosage. In this way, the yield and purity of the target product can be effectively improved to achieve the desired synthesis effect.

4-Bromo-6-trifluoromethyl-pyridine-2-carboxylate ethyl ester, which is colorless to light yellow liquid or solid. Its melting point is about [X] ℃, boiling point is [X] ℃, density is [X] g/cm ³, and it exists stably under specific conditions.
Looking at its solubility, in organic solvents such as ethanol, ether, and dichloromethane, it has good solubility, just like fish getting water, and can dissolve with it; however, in water, its solubility is poor, just like the intolerance of oil and water. Because the molecular structure of the compound is dominated by hydrophobic bromine atoms, trifluoromethyl and ester groups, the force between it and water molecules is weak.
When it comes to chemical activity, the bromine atoms in the compound are active and can participate in many nucleophilic substitution reactions like smart dancers. For example, when encountering nucleophiles containing hydroxyl groups and amino groups, bromine atoms are easily replaced to form new compounds, which is like an "exchange dance" between atoms. The ester group is not inferior, and can undergo hydrolysis reaction under the catalysis of acid or base. In an acidic environment, such as in a dilute sulfuric acid solution, it is slowly hydrolyzed into the corresponding carboxylic acid and ethanol; under alkaline conditions, such as sodium hydroxide solution, hydrolysis is more rapid, resulting in carboxylate and ethanol, which are typical reaction characteristics of ester compounds.
Furthermore, the trifluoromethyl group in the molecule gives it unique chemical and physical properties. Trifluoromethyl has strong electron absorption and can affect the distribution of molecular electron clouds, which in turn changes the reactivity and stability of the compound. It is like injecting a different kind of "energy" into the molecule, making the compound have special uses and value in the field of organic synthesis. It is like a unique "chemical pearl", shining on the stage of synthesis.

I don't know the exact price range of ethyl 4-bromo-6-trifluoromethyl-pyridine-2-carboxylate on the market. However, if you want to know the price of this product, you can explore it from many places.
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4-Bromo-6-trifluoromethyl-pyridine-2-carboxylate ethyl ester, this substance is a commonly used raw material in organic synthesis, and its storage conditions are very critical.
It should be placed in a cool, dry and well-ventilated place. A cool environment can inhibit its chemical reactions caused by excessive temperature. If the temperature is too high, it may cause adverse changes such as decomposition and polymerization, which will damage its quality and purity. Drying conditions are also indispensable, because it has certain chemical activity. In contact with water or humid air, or reactions such as hydrolysis, it changes its chemical structure and causes it to fail.
Furthermore, the storage place should be kept away from fire, heat sources and oxidants. This compound may be flammable. In case of fire or heat source, there is a risk of fire or even explosion. The oxidant can oxidize with it and change its chemical properties, so it must be isolated from it.
In addition, storage containers must also be selected with caution. It is advisable to use containers with good sealing performance, such as glass bottles or specific plastic bottles, to prevent contact with air and reduce the possibility of volatilization and reaction with airborne components. After taking it, be sure to seal the container in time to maintain the stability of its storage environment. During the storage process, its appearance, odor, and other properties should also be checked regularly. If there is any abnormality, it needs to be tested immediately to determine whether it has deteriorated, and to ensure that it still has the required chemical properties and purity during use, so as to facilitate the smooth development of subsequent organic synthesis and other related work.