4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE

This is a study on the chemical structure of 4-bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine. Looking at its name, its structural characteristics can be gradually analyzed.
"4-bromine", that is, at position 4 of the main structure, there is a bromine atom connected. Bromine atom is a halogen element with a large atomic radius and a certain electronegativity. It can play a unique role in chemical reactions, or affect the polarity and reactivity of molecules.
"2-iodine", indicating that the iodine atom is connected at position 2. The iodine atom is also a halogen element with a larger atomic radius and relatively small electronegativity. Its existence may change the spatial structure of the molecule, and it has a significant impact on the reactivity and physical properties.
"1- (benzenesulfonyl) ", which is connected to the benzenesulfonyl group at position 1. The benzenesulfonyl group contains a benzene ring structure, and the benzene ring has a conjugated system, which is a planar structure and has stable properties. The sulfur atom in the sulfonyl group connects two oxygen atoms, which has strong electron absorption, or changes the electron cloud distribution of the main structure, which affects the chemical properties of the molecule.
"1H-pyrrolido [2,3-b] pyridine", this is the main structure. The pyrrole-pyridine structure is formed by fusing a pyrrole ring with a pyridine ring. The pyrrole ring is a nitrogen-containing five-membered heterocyclic ring with certain aromaticity, and the solitary pair electrons on the nitrogen atom participate in the conjugation system. The pyridine ring is a nitrogen-containing six-membered heterocyclic ring, and the nitrogen atom is basic. Because the electronegativity of the nitrogen atom is greater than that of the carbon atom, the electron cloud on the ring is unevenly distributed. After fusing the two, a unique electronic structure and spatial configuration are formed, which endows the molecule with special chemical and physical properties.
Overall, the chemical structure of 4-bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine, due to the interaction of each substituent and the main structure, forms a unique electron cloud distribution and spatial configuration, which determines its chemical reactivity and physical properties.

4-Bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine has a wide range of uses in the field of organic synthesis.
First, it can be used as a key intermediate for the creation of other nitrogen-containing heterocyclic compounds. With its unique structure, it can introduce various functional groups through various reactions, such as nucleophilic substitution and coupling reactions, to expand the structural types of compounds. For example, in the Suzuki coupling reaction, the halogen atom of this compound can react with aryl boronic acid to form novel carbon-carbon bonds, thereby synthesizing complex organic molecules with specific structures and functions. In the field of medicinal chemistry, it is helpful to develop new pharmaceutical active ingredients.
Second, it can also be used in the field of materials science. Because of its special heterocyclic and sulfonyl structure, it imparts specific electrical and optical properties to the compound. It can be chemically modified to prepare organic semiconductor materials, which can be used in organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other devices to improve the carrier transport performance and luminous efficiency of materials, and promote the development of organic electronic devices.
Third, in the process of drug development, as a lead compound for structural optimization. Scientists can modify different substituents based on their basic skeleton to explore the relationship between structure and activity, hoping to discover potential drug molecules with high activity, high selectivity and low toxicity and side effects. For example, for specific disease-related targets, rationally design and modify them to screen out candidate drugs with significant effects on disease treatment.

To prepare 4-bromo-2-iodine-1 - (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine, the method of synthesis can be obtained in several ways.
First, pyrrolido [2,3-b] pyridine is used as a group, and benzenesulfonyl is introduced first. Pyrrolido [2,3-b] pyridine can be reacted with benzenesulfonyl chloride in an alkaline environment. Bases such as potassium carbonate and triethylamine, in suitable solvents such as dichloromethane, N, N-dimethylformamide, stirred at controlled temperature, can obtain 1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine. Thereafter, the step of halogenation is performed. A bromine atom can be introduced at a suitable check point with a brominating agent, such as N-bromosuccinimide (NBS), in an inert solvent such as carbon tetrachloride, in the presence of an initiator such as benzoyl peroxide, by light or heat to give 4-bromo-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine. Then, with an iodizing agent, such as a combination of potassium iodide and hydrogen peroxide, or with iodine and a suitable oxidizing agent, in a suitable solvent such as acetonitrile, an iodine atom can be introduced to obtain the target product 4-bromo-2-iodine-1 - (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine.
Second, pyridine derivatives with suitable substituents can also be started. Pyrrole ring is constructed first, and benzenesulfonyl is introduced at the same time. For example, a pyridine-containing reactive functional group is reacted with a benzenesulfonyl-containing reagent in multiple steps to form a pyrrolido [2,3-b] pyridine skeleton. Subsequent bromination and iodization operations are carried out in sequence, and the reagents and conditions used are similar to the above methods, and this compound can also be prepared. During the reaction process, it is necessary to pay attention to the control of the reaction conditions of each step, such as temperature, reaction time, reagent dosage, etc., in order to improve the yield and obtain a pure product.

4-Bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine is an organic compound. Its physical properties are worth exploring, as follows:
- ** Appearance and properties **: Usually in a solid state. However, the specific appearance of organic compounds may vary depending on the purity and preparation method. In high purity, or white to light yellow crystalline solid, if it contains impurities, the color is deeper, and the appearance may be in different forms such as powder and block.
- ** Melting point and boiling point **: Melting point is one of the key physical properties, which can reflect the strength of intermolecular forces. There are interactions such as van der Waals force and hydrogen bond between the molecules of this compound, resulting in its melting point in a specific range. Unfortunately, the exact literature has not reported its melting point value. The boiling point is also affected by the molecular structure and interaction. Due to the presence of heavy atoms such as bromine and iodine and groups such as benzenesulfonyl in the molecule, the molecular weight increases, the intermolecular force increases, and the boiling point may be higher. However, there is also a lack of exact boiling point data.
- ** Solubility **: Due to its structure containing hydrophobic groups such as benzene ring and pyridine ring, its solubility in water is not good. Because water is a polar solvent, and the polarity of this compound is relatively small, it is difficult to dissolve in water according to the principle of "similar miscibility". However, in organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., it may have a certain solubility. Because the polarity of organic solvents is similar to that of this compound, it can weaken the intermolecular force and promote its dissolution.
- ** Density **: The density is related to the molecular weight and the way of molecular stacking. Because it contains heavy atoms of bromine and iodine, the molecular weight is large, and the theoretical density may be greater than that of water. However, the specific density value needs to be accurately determined by experiments.
- ** Stability **: Bromine and iodine atoms in the molecule are active check points, or participate in reactions such as substitution and elimination, which affect the stability. Benzenesulfonyl groups are relatively stable, but reactions may also occur under extreme conditions such as strong acids, strong Therefore, the compound needs to be stored under suitable conditions, such as in a dry and cool place, to avoid contact with the active substance in order to maintain its stability.

4-Bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine, which is still difficult to break in the current market prospect.
The field of chemical synthesis, due to its unique structure, may be a key intermediate for the creation of novel drugs and functional materials. In the process of drug development, there is a strong demand for small molecule compounds with specific activities. The pyrrolidine skeleton of this compound, supplemented by the modification of bromine, iodine and benzenesulfonyl groups, may endow it with the ability to specifically bind to biological targets, and has potential applications in the creation of anti-cancer, anti-infection and other drugs. Therefore, in terms of pharmaceutical R & D enterprises and scientific research institutions, it may have considerable attractiveness, which is expected to lead to an increase in related research investment, and then promote its market demand.
Re-explore the field of materials science, and there is also a strong demand for compounds with special electronic structures and optical properties in the field of organic optoelectronic materials. Bromine and iodine atoms can adjust the electron cloud distribution of molecules, while benzenesulfonyl groups can affect the accumulation mode and stability of molecules. Therefore, 4-bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine may be used to develop new organic semiconductors, light-emitting materials, etc., in display technology, optoelectronic device manufacturing and other industries, or usher in an opportunity for development.
However, it is also necessary to be clear that the road to market expansion is not smooth. The complexity of the synthesis process and the difficulty of cost control are all questions to be solved. Synthesis of this compound may require exquisite reaction routes and strict reaction conditions. If the synthesis process cannot be effectively optimized, the cost will remain high, which will hinder its large-scale production and marketing activities. In addition, the strict regulation of regulations and the competition of similar alternative products are also challenges that cannot be ignored.
In summary, 4-bromo-2-iodine-1- (benzenesulfonyl) -1H-pyrrolido [2,3-b] pyridine has potential opportunities in the field of medicine and materials, but in order to emerge in the market, it is still necessary for scientific research and industry to work together to overcome problems such as synthesis and cost in order to achieve broad prospects.