4-Bromo-2-hydroxypyridine

4-Bromo-2-hydroxypyridine is an organic compound with unique physical properties. Its properties are usually crystalline, mostly solid at room temperature, or white to pale yellow powder. The color varies according to the purity. The higher the purity, the more the color approaches pure white.
In terms of melting point, it is about 150-155 ° C. The melting point is an important physical constant of the substance, which is of great significance for its identification and purity judgment. 4-Bromo-2-hydroxypyridine changes from solid to liquid in this temperature range. This property can be used to purify and identify the compound.
In terms of solubility, it is slightly soluble in water. Water is a common solvent. The degree of solubility of this substance in water is limited, but it can be soluble in some organic solvents, such as methanol, ethanol, dichloromethane, etc. This difference in solubility comes from its molecular structure, which includes both hydroxyl groups that can form hydrogen bonds with water molecules, and bromine atoms and pyridine rings, which make the molecule have certain hydrophobicity, so it has better solubility in organic solvents. This property is crucial in the separation and purification steps of organic synthesis.
4-Bromo-2-hydroxypyridine also has certain sublimation properties. Although the sublimation phenomenon requires specific conditions, such as reduced pressure and moderate heating, its sublimation properties may be utilized in the separation and purification process. By controlling the conditions, the substance can be sublimated and separated from the mixture to obtain high-purity products. 4-Bromo-2-hydroxypyridine is widely used in the field of organic synthesis due to its structure containing bromine atom, hydroxyl group and pyridine ring, and can be used as a key intermediate to participate in many organic reactions and construct complex organic molecular structures.

4-Bromo-2-hydroxypyridine is also an organic compound. Its chemical properties are unique and interesting, and it is an important object for chemical study.
First of all, its acidity and alkalinity. Because there are hydroxyl groups in the molecule, it has a certain acidity. The hydrogen atom of the hydroxyl group can be partially dissociated, and in a suitable environment, it can exhibit the characteristics of an acid and neutralize with a base. And the nitrogen atom of the pyridine ring has a lone pair of electrons, making the compound slightly basic and can be combined with protons.
Describe its nucleophilic substitution reaction. Bromine atom is a good leaving group, and in this compound, it is vulnerable to attack by nucleophiles. If there are nucleophiles such as alkoxides and amines, bromine atoms can be replaced to form a series of new compounds. This reaction is widely used in the field of organic synthesis.
Then talk about its redox properties. Both pyridine rings and hydroxyl groups can participate in the redox process. Hydroxyl groups can be oxidized to higher valence functional groups such as aldehyde groups and carboxyl groups under the action of appropriate oxidants; pyridine rings can also undergo oxidation reactions under specific conditions. On the contrary, in case of suitable reducing agents, pyridine rings can be reduced, causing their electron cloud distribution and chemical activity to change.
has its complexation properties with metal ions. The nitrogen atom and the oxygen atom of the hydroxyl group both have lone pair electrons, which can form coordination bonds with metal ions to form metal complexes. Such complexes have potential applications in catalytic reactions and materials science.
In short, 4-bromo-2-hydroxypyridine has rich and diverse chemical properties and plays an important role in many fields such as organic synthesis, materials science, and medicinal chemistry, which are worthy of further investigation and study.

4-Bromo-2-hydroxypyridine is also an important compound in organic synthesis. There are several common synthesis methods.
One is to use 2-hydroxypyridine as the starting material for bromination reaction. Appropriate brominating reagents, such as bromine ($Br_2 $), can be used to replace the hydrogen atom at a specific position on the pyridine ring under suitable reaction conditions to obtain the target product. When reacting, it is necessary to pay attention to the temperature of the reaction, the choice of solvent and other factors. If the temperature is too high, side reactions such as excessive bromination may occur; the properties of the solvent will also affect the rate and selectivity of the reaction. Commonly selected solvents include halogenated hydrocarbons such as dichloromethane and carbon tetrachloride. Due to their good solubility to reactants and products, and relatively stable chemical properties, they will not cause too many side reactions with various substances in the reaction system.
The second can be started from pyridine derivatives and reacted in multiple steps to construct the target structure. First, the pyridine ring is properly functionalized, so that the pyridine ring has groups that can be further converted into hydroxyl and bromine atoms. For example, a suitable substituent is introduced first, and then the hydroxyl and bromine atoms are gradually introduced at specific positions through reaction steps such as hydrolysis and halogenation. Although there are many steps in this method, the position and type of substituents on the pyridine ring can be precisely controlled, which is suitable for situations where the purity and structure of the product are strictly required.
The third is a reaction strategy catalyzed by transition metals. The unique catalytic properties of transition metal catalysts are used to realize the construction of carbon-bromine bonds and carbon-oxygen bonds. For example, transition metal catalysts such as palladium ($Pd $) can be used to catalyze the reaction of halogenated pyridine with suitable nucleophiles with the assistance of ligands, thereby introducing hydroxyl groups on the pyridine ring. At the same time, by adjusting the structure of the reaction substrate and the reaction conditions, the retention or introduction of bromine atoms at specific positions in the pyridine ring can be achieved. This method has the advantages of mild reaction conditions and high selectivity.
There are various methods for synthesizing 4-bromo-2-hydroxypyridine, and each method has its advantages and disadvantages. In actual synthesis, the appropriate synthesis path needs to be carefully selected according to many factors such as the availability of raw materials, the purity requirements of the product, and cost considerations.

4-Bromo-2-hydroxypyridine is useful in many fields. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to the unique structure of the pyridine ring and bromine and hydroxyl groups, it is endowed with specific chemical and biological activities. It can be chemically modified to construct compounds with various pharmacological activities, or act on specific targets, participating in the process of disease treatment, such as the development and synthesis of anticancer drugs and antibacterial drugs.
In the field of materials science, it also has extraordinary performance. Due to its special molecular structure, it can be used as a building block for functional materials. Or it can be used to prepare organic luminescent materials, which can realize luminescent function under specific conditions through their electronic structure characteristics, and may have potential applications in display technology. Or it can participate in the preparation of materials with special electrical and optical properties to meet the special needs of electronic devices and other fields.
In the field of organic synthetic chemistry, 4-bromo-2-hydroxypyridine is an extremely important reaction substrate. Bromine atoms can participate in nucleophilic substitution reactions, and hydroxyl groups can also participate in many types of reactions, such as esterification, etherification, etc. With this, chemists can ingeniously design reaction pathways, construct complex organic compounds, expand the boundaries of organic synthesis, and provide an effective way to create new organic molecules.

4-Bromo-2-hydroxypyridine, the price of this product in the market is difficult to determine. Since its price often varies due to various reasons, it cannot be generalized.
First, the difficulty of its preparation has a lot to do with it. If the preparation method is complicated, all kinds of rare reagents are required, or the process is exquisite, and the requirements for equipment and craftsmen are quite high, the cost will increase, and the price will also rise.
Second, the state of market supply and demand is the key to controlling the price. If there are many people who want it, and the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the merchant will sell its goods, and the price may drop.
In addition, the purity of the product is also the main factor. The higher the purity, the more difficult it is to prepare, the more effort and cost are required, and the price will be higher.
And the origin is different, the price may vary. The difference in the cost of raw materials and taxes in various places can make the price different.
In the past, at a certain time and place, due to the improvement of the preparation method, the cost was slightly reduced, and the price between the markets also fell. However, or due to a certain accident, the raw materials were scarce, and the seekers did not decrease, and the price rose again. < Br >
Therefore, in order to know the exact market price of 4-bromo-2-hydroxypyridine, it is necessary to consider the factors of supply and demand at that time, the difficulty of preparation, product purity and origin in detail, and then a more accurate number can be obtained.