4-Bromo-2-fluoro-5-methylpyridine

4-Bromo-2-fluoro-5-methylpyridine has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. With its unique chemical structure, it plays an important role in the construction of complex organic molecular structures. For example, the reaction properties of halogenated hydrocarbons can react with many nucleophiles to achieve the construction of carbon-carbon bonds and carbon-heteroatomic bonds, and then synthesize a series of organic compounds with specific biological activities or functions.
In the field of medicinal chemistry, derivatives of 4-bromo-2-fluoro-5-methylpyridine show potential medicinal value. Scientists are expected to develop new drugs by modifying and modifying their structures. For example, in the development of antibacterial drugs, some compounds derived from this basis have been experimentally verified to have significant inhibitory effects on specific pathogens, providing a promising direction for the creation of new antibacterial drugs.
In the field of materials science, it also has outstanding performance. It can be used as a starting material for the synthesis of special functional materials. For example, polymer materials with specific photoelectric properties are prepared by polymerization with other functional monomers, which are used in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices to improve the performance and efficiency of the devices.
In summary, 4-bromo-2-fluoro-5-methyl pyridine has important uses in many fields such as organic synthesis, drug development and materials science due to its unique structure, providing an important material foundation and innovation opportunity for research and development in related fields.

4-Bromo-2-fluoro-5-methylpyridine is a member of the family of organic compounds. According to its physical properties, it is mostly liquid or solid at room temperature and pressure. As for the exact form, it depends on the strength of the intermolecular force.
When talking about the melting point, the melting point of this compound is the temperature at which a substance melts from a solid state to a liquid state. However, the specific value needs to be accurately determined by experiments, and the melting point will also be affected by the amount of impurities. Generally speaking, compounds with similar structures have a high melting point if the intermolecular force is strong; otherwise, it is low.
The boiling point is the temperature at which the compound changes from a liquid state to a gas state. The boiling point of 4-bromo-2-fluoro-5-methylpyridine also needs to be obtained experimentally. Its boiling point is closely related to the intermolecular force and the relative molecular weight. The larger the relative molecular weight, the stronger the intermolecular force, and the higher the boiling point.
In terms of solubility, this compound behaves differently in different solvents. In organic solvents such as ethanol, ether, etc., or exhibits good solubility, due to the principle of "similar miscibility", its organic structure is compatible with the structure of organic solvents. However, its solubility in water may be poor, because the polarity of the molecule is quite different from that of water, and it is difficult to form effective interactions between water molecules and the compound molecules. < Br >
Density is also one of the important physical properties. Its density is indicative of the mass of the substance per unit volume. Accurate determination of the density of this compound is of great significance for many practical applications. The density is related to the degree of tight packing of molecules and the relative molecular mass.
In appearance, pure 4-bromo-2-fluoro-5-methyl pyridine, or colorless to light yellow liquid or solid, but the appearance may change due to the mixing of impurities or storage conditions.
In terms of odor, it may have a special organic odor, but the odor description is more subjective, and it is necessary to be carefully sniffed and identified under the premise of safe operation.
The physical properties of this compound have a profound impact on its application in organic synthesis, drug development and other fields. Only by knowing its physical properties can we reasonably choose the reaction conditions, separation and purification methods to achieve the expected experimental and production goals.

The chemical synthesis of 4-bromo-2-fluoro-5-methylpyridine is an important topic in the field of organic synthesis. There are various synthesis paths, one of which is described in detail below.
Starting material, 2-fluoro-5-methylpyridine can be selected. This compound can be obtained through a suitable fluorination reaction through the corresponding pyridine derivative. The fluorination reaction usually requires the selection of a suitable fluorination reagent, such as Selectfluor, etc., in a suitable solvent, at a specific temperature and reaction conditions.
After obtaining 2-fluoro-5-methylpyridine, bromine atoms can be introduced, and bromination can be used. Commonly used brominating reagents, such as N-bromosuccinimide (NBS), often use carbon tetrachloride as a solvent, and in the presence of an initiator such as benzoyl peroxide, heat or light initiates the reaction. This reaction mechanism is that the initiator produces free radicals, which promote the substitution reaction of bromine free radicals with 2-fluoro-5-methyl pyridine, so that bromine atoms are introduced at the 4-position of the pyridine ring, and finally 4-bromo-2-fluoro-5-methyl pyridine is formed.
During the reaction process, the reaction process should be closely monitored, and thin layer chromatography (TLC) can be used. After the reaction is completed, the product needs to be separated and purified. Commonly used methods, such as column chromatography, select appropriate stationary and mobile phases to achieve the purpose of purifying the product.
In addition, there are other synthetic ideas. For example, 4-bromo-2-fluoropyridine is used as the starting material, and methyl is introduced through methylation reaction. Methylation reagents can be selected from iodomethane, etc. Under alkaline conditions, such as the presence of potassium carbonate and other bases, in a suitable solvent to achieve the introduction of 5-position methyl, the target product 4-bromo-2-fluoro-5-methylpyridine can also be obtained. In short, there are various methods for synthesizing 4-bromo-2-fluoro-5-methylpyridine, and it is necessary to weigh the advantages and disadvantages of each method according to the actual situation and choose the appropriate synthesis path.

4-Bromo-2-fluoro-5-methylpyridine is on the market, and its price range is difficult to determine. The price of this chemical is affected by many factors.
First, the quantity has a great impact. If the purchase volume is huge, the merchant may give the best discount in order to promote the sale, and the price should be reduced; and if you buy a small amount, the unit price is often high.
Second, the source price is also different. Those who come from a factory with good reputation and excellent production technology have excellent quality, and the price may be high; however, if they come from a small factory, the quality may be inferior, and the price may be cheaper. But the evaluation of quality is not only about price, but also about the effectiveness of use. < Br >
Third, the supply and demand of the city is also the main reason. If the demand exceeds the supply, the price will rise; if the supply exceeds the demand, the price will fall. If the industry is in a prosperous period, the demand for this product will increase greatly, and the price will rise; if the industry is in a off-season, the demand will be less, and the price will drop.
Fourth, the difficulty of preparation is also related to the price. If the preparation process is complicated, time-consuming, and the materials used are expensive, the price will be difficult to lower; on the contrary, the process is simple and the materials used are common, and the price is expected to drop.
The price of 4-bromo-2-fluoro-5-methylpyridine on the market ranges from a few yuan to tens of yuan per gram, or even higher, so it is difficult to determine a price. To know the exact price, you need to consult the suppliers in detail, compare their quotations, and make a comprehensive judgment before you can make a suitable choice.

4-Bromo-2-fluoro-5-methylpyridine is a commonly used chemical raw material in organic synthesis. It has unique chemical activity and is related to many safety precautions. Details are as follows:
1. ** Toxicity prevention **: This compound may be toxic to a certain extent, or it may endanger the human body through inhalation, skin contact, or ingestion. When operating, be sure to wear appropriate protective equipment, such as gas masks, protective gloves, protective glasses, and laboratory clothes, etc., to avoid direct contact. After the operation, the exposed skin should be washed in time to prevent residual toxic damage.
2. ** Fire and explosion risk **: Although its flammability data may be limited, many organic compounds are flammable. When storing and using, keep away from fire sources, heat sources and strong oxidants to prevent fire and explosion accidents. The operation site should be equipped with suitable fire extinguishing equipment, and the operator should also be familiar with its use.
3. ** Storage points **: It should be stored in a cool and well-ventilated place, away from fire and heat sources. The storage container must be sealed to prevent leakage. Avoid mixing with oxidants, acids, alkalis, etc., and react violently with them. At the same time, the chemical storage regulations should be strictly followed, and labels and records should be made to facilitate management and traceability.
4. ** Emergency treatment for leakage **: In case of leakage, personnel from the leakage contaminated area should be quickly evacuated to the safe area, and quarantined, and access should be strictly restricted. Emergency personnel must wear protective equipment and respirators, and do not let leaks come into contact with combustible substances. When a small amount leaks, it can be absorbed by inert materials such as sand and vermiculite; when a large amount leaks, a dike or a pit should be built for containment, and transferred to a special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.
5. ** Operation Specifications **: The operation should be carried out in a fume hood to ensure good ventilation conditions and timely discharge of volatile harmful gases. The operation should be rigorous and meticulous to avoid leakage caused by improper operation of the container rupture, dumping, etc. And do not eat, smoke in the laboratory to prevent the intake of poisons.
In conclusion, when using 4-bromo-2-fluoro-5-methylpyridine, operators should fully understand its characteristics, strictly follow safety operating procedures, and take protective and emergency measures to ensure personal safety and environmental safety.