4-BROMO-2-(DIMETHYLAMINO)PYRIDINE

4-Bromo-2- (dimethylamino) pyridine, this is an organic compound. Its chemical properties are unique and have a variety of remarkable characteristics.
First of all, its structure, the pyridine ring is the core, and the bromine atom and dimethylamino are connected to the specific position of the pyridine ring. This structure endows it with unique electronic effects and steric resistance, which has a great impact on the chemical properties.
In terms of reactivity, amino groups have electron-giving properties, which can increase the electron cloud density of the pyridine ring, especially in the amino o and para-positions. Therefore, the electrophilic substitution reactivity increases and it is more susceptible to attack by electrophilic reagents. For example, in the case of halogenated reagents, halogenation reactions can occur at specific positions in the pyridine ring under suitable conditions, and the reaction check point has a certain selectivity due to the amino localization effect.
Bromine atoms are active and can participate in a variety of reactions. In nucleophilic substitution reactions, bromine atoms can be replaced by many nucleophilic reagents. For example, when reacting with nucleophilic reagents such as alkoxides and amines, bromine leaves to form corresponding substituted products, thereby realizing structural modification and derivatization of compounds.
This compound also has certain alkalinity. Dimethylamino nitrogen atoms have lone pairs of electrons, which can bind protons and exhibit alkalinity. In acidic environments, it can form salts with acids. This property may have applications in separation, purification and control of specific reaction conditions.
In addition, its solubility also needs to be concerned. Because the molecule has both polar groups (amino groups) and non-polar moieties (pyridine rings, bromine atoms), the solubility in organic solvents may vary depending on the polarity of the solvent. Generally speaking, it has a certain solubility in polar organic solvents such as ethanol and acetone, but low solubility in non-polar solvents. This solubility characteristic is an important consideration in the synthesis, separation and application of compounds.

4-Bromo-2- (dimethylamino) pyridine is an important raw material for organic synthesis. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the creation of new drugs. Due to its unique structure, it can participate in a variety of chemical reactions, help build complex drug molecular structures, and then open up new avenues for the treatment and drug development of diseases.
In the field of materials science, it also has extraordinary functions. It can be used to prepare materials with special properties or optimize the properties of existing materials. With its chemical activity, it can intervene in the synthesis process of materials, so that materials can obtain better stability, conductivity or optical properties, and contribute significantly to the development and improvement of new materials.
In the field of organic catalysis, 4-bromo-2- (dimethylamino) pyridine can be used as a high-efficiency catalyst. It can effectively catalyze many organic reactions, improve the reaction rate and yield, and has good selectivity. Under the concept of green chemistry, this efficient and selective catalytic property has increasingly highlighted its important value, helping to achieve a more environmentally friendly and efficient organic synthesis process and promoting the sustainable development and progress of organic synthesis chemistry.

The synthesis method of 4-bromo-2- (dimethylamino) pyridine, although the ancient book "Tiangong Kaiwu" does not contain this substance, it can be done by modern organic synthesis methods.
First, 2-aminopyridine is used as the starting material. Shilling 2-aminopyridine reacts with bromine in an appropriate solvent, such as glacial acetic acid. During the reaction, the temperature should be controlled at a low temperature, such as 0-5 ° C, and bromine is slowly added dropwise to achieve a 4-position selective bromide to obtain 4-bromo-2-aminopyridine. In this step, attention should be paid to the strong oxidizing and corrosive properties of bromine, and the operation should be cautious. < Br >
times, 4-bromo-2-aminopyridine is reacted with dimethyl sulfate. This reaction is better carried out in an alkaline environment, such as potassium carbonate as a base, and refluxed in an organic solvent such as acetonitrile. Dimethyl sulfate provides methyl and reacts with amino to form dimethylamino, resulting in 4-bromo-2 - (dimethylamino) pyridine. However, dimethyl sulfate is highly toxic and must be operated in a well-ventilated environment with strict protection.
Second, 2-chloropyridine can also be used as a starting point. First react with copper bromide in the presence of a suitable ligand, such as 1,10-o-phenanthroline, in a high-boiling solvent, such as N, N-dimethylformamide, by heating to achieve the 4-position bromide, resulting in 4-bromo-2-chloropyridine.
Then, 4-bromo-2-chloropyridine reacts with dimethylamine. With a suitable catalyst, such as potassium iodide, in a suitable solvent, such as ethanol, heated and refluxed, the chlorine atom is replaced by dimethylamino, and the final product is 4-bromo-2 - (dimethylamino) pyridine. When operating, pay attention to the pungent odor and corrosiveness of dimethylamine and take protective measures.

4-Bromo-2- (dimethylamino) pyridine is a very important raw material and intermediate in organic synthesis. During storage and transportation, pay attention to the following things:
First, when storing, it must be placed in a cool, dry and well-ventilated place. This substance is quite sensitive to moisture and is highly susceptible to moisture and deterioration, so it should be kept away from water sources and humid places. If it is placed in a humid environment, it may cause chemical reactions such as hydrolysis, which will affect its quality and performance.
Second, it needs to be strictly sealed and stored. Because it is volatile and easy to react with oxygen, carbon dioxide and other substances in the air, sealed storage can effectively avoid excessive contact with air. You can choose a suitable sealed container, such as a glass bottle with a sealed lid, or a sealed plastic container.
Third, the storage temperature should also be strictly controlled. Generally speaking, it is recommended to store in a low temperature environment, usually in the range of -20 ° C to 25 ° C. If the temperature is too high, it may accelerate its decomposition or cause other chemical reactions; if the temperature is too low, it can inhibit the reaction, or cause it to solidify, inconvenient to use, and some low temperature environments may cause physical morphological changes and affect its chemical activity.
Fourth, when transporting, ensure that the packaging is firm. To prevent the packaging from being damaged due to bumps and collisions during transportation, resulting in material leakage. At the same time, the transportation tool should also be kept dry and clean to avoid mixing with other substances that may react with it.
Fifth, be sure to follow relevant transportation and storage regulations. Because it may belong to the category of hazardous chemicals, transportation and storage must comply with specific regulations and standards to ensure the safety of personnel and the environment. During handling, operators should also take protective measures, such as wearing gloves, goggles, etc., to prevent contact with skin and eyes and cause injury.

4-Bromo-2- (dimethylamino) pyridine, the price of this product in the market is difficult to be fixed, and its price often changes for many reasons.
First, the amount of production is related to its price. If the product is abundant and the supply in the market exceeds the demand, the price may decline; if the product is scarce and the supply exceeds the demand, the price will rise.
Second, the rise and fall of demand is also the main reason. If many industries have urgent demand for it at a certain time, it will be used in chemical synthesis, pharmaceutical research and development, etc., and the demand will be prosperous and the price will be high; if the demand is flat, the price will also decline.
Third, the quality affects the price. Those with high quality have few impurities and high purity, and the price is not cheap; if the quality is slightly inferior, the price is correspondingly lower.
Fourth, the distance of transportation and the amount of cost also affect the price. If the origin is far away from the user, the transportation cost is high, and the cost is added, the price will increase; if the origin is similar, the transportation is convenient, and the cost is saved or cheap.
According to past market conditions, the price of this product may be between tens of yuan and hundreds of yuan per gram. However, this is only a rough figure. The current price must be consulted in detail with the supplier of chemical raw materials, or carefully checked on the chemical product trading platform, before the exact number can be obtained. Due to the fickle market conditions, the real-time price cannot be assumed.