4-Bromo-2-chloropyridine 98%

4-Bromo-2-chloropyridine, with a content of 98%, is widely used. In the field of medicinal chemistry, it is often used as a key intermediate. Pharmaceutical synthesis is like a delicate tapestry, and the structure of many drug molecules needs to be gradually built according to specific intermediates. Due to its unique chemical structure, 4-bromo-2-chloropyridine can be combined with different reagents through various reactions, such as nucleophilic substitution reactions, paving the way for the creation of novel and biologically active compounds. It has been seen in the development of many antibacterial, anti-inflammatory and anti-tumor drugs, just like an indispensable cornerstone for building a magnificent building.
In the field of pesticide chemistry, it also plays an important role. Pesticides are designed to effectively control pests and diseases and ensure the growth of crops. 4-Bromo-2-chloropyridine can participate in the synthesis of many high-efficiency, low-toxicity and environmentally friendly pesticides. For example, after being modified by a specific reaction, it can be derived from compounds with high selective toxicity to specific pests, which can not only accurately target pests, but also minimize the adverse effects on non-target organisms and the environment, and contribute to the sustainable development of agriculture.
In addition, in the field of materials science, it also has certain applications. With the advancement of science and technology, the demand for new materials is increasing day by day. 4-Bromo-2-chloropyridine can be used as a starting material for the construction of certain functional materials. After a series of complex chemical transformations, materials with unique electrical, optical or mechanical properties can be prepared and applied to many cutting-edge fields such as electronic devices and optical instruments, promoting the development of materials science to new heights.

4-Bromo-2-chloropyridine, with a content of 98%, the market price often fluctuates due to a variety of reasons. Looking at the market of chemical materials in the past, the price of such fine chemicals often depends on factors such as the abundance of raw materials, the difficulty of preparation, and the amount of demand.
If the raw materials are full, the price may be stable and easy. However, if the raw materials are rare, the supply is difficult, and the cost will rise, and the price will also be high. If the preparation method is complicated and requires special methods and expensive tools, the price will not be cheap. The complex process is labor-intensive and time-consuming, and the cost will increase.
Furthermore, market demand is the key. The demand is strong, the supply is in short supply, and the price may rise sharply; if the demand is sluggish, the supply exceeds the demand, and the price will decline.
According to the price trend of chemical materials contained in books such as Tiangong Kaiwu in the past, the price of 4-bromo-2-chloropyridine with 98% content may be around tens of yuan to hundreds yuan per gram in the market. However, this is only an approximate number. The actual price depends on the current market conditions, or varies from time to time, so it is difficult to determine.

To prepare 4-bromo-2-chloropyridine, the preparation method is quite exquisite. Take the pyridine as the base first, because its ring is active and can start the end of the reaction. Dissolve the pyridine in a suitable solvent, such as aprotic dichloromethane, which can stabilize the reaction environment and help the reaction to run smoothly.
The first step is halogenation, adding a bromine source, such as liquid bromine, and Lewis acid such as iron tribromide as the catalyst. Under the catalysis of bromine ions, electrophilic attacks the pyridine ring. Due to the electron absorption of pyridine nitrogen, the electron cloud density at the β site is slightly higher, and bromine preferentially occupies the site, resulting in 2-bromopyridine. In this step, the temperature needs to be controlled at a low temperature, about 0 ° C to 5 ° C, to prevent the generation of side reactions, such as the formation of polybrominated compounds.
In the next step, 2-bromopyridine is used as the substrate, and the chlorine source is replaced, such as thionyl chloride, and the catalytic Lewis acid is also added, such as anhydrous zinc chloride. At moderate temperature, about 60 ° C to 80 ° C, the chlorine atom is replaced by nucleophilic, and the bromine of 2-bromopyridine is replaced to obtain the target substance 4-bromopyridine. During this step of reaction, time monitoring is required. By thin-layer chromatography, the consumption of raw materials and the generation of products can be observed.
After the reaction is completed, First separate the liquid, remove the organic phase containing the product in the lower layer, then wash it with an alkali solution such as sodium bicarbonate, remove the unwanted acid, and then dry it with a desiccant such as anhydrous sodium sulfate. Finally, after reduced pressure distillation, according to the boiling point of the product, the purified 4-bromo-2-chloropyridine can be obtained, which can reach 98% purity. The whole process, each step of the conditions needs to be strictly controlled to obtain a high-purity product.

4-Bromo-2-chloropyridine, content 98%, the Quality Standard of this chemical is related to many important aspects. One is the appearance, which should usually appear as a white to off-white crystalline powder with uniform texture and no obvious color differences and impurities visible. The second is the purity, which is established at 98% purity and needs to be determined by rigorous analytical methods, such as high-performance liquid chromatography (HPLC), to accurately determine the content of its main components, and the remaining impurity content should be strictly controlled, so as not to affect its performance and application. The third is the melting point. The substance has a specific melting point range. The value should be within the corresponding standard range when accurately measured by the melting point tester, which can assist in judging its purity and crystal structure. The fourth is the moisture content. The amount of moisture has a great impact on its stability and reactivity. It is often determined by Karl Fischer's method and should be maintained at a low level to ensure the stability of the product. There is also pH, which needs to be maintained within a certain range to avoid adverse effects on subsequent reactions or use. It is mostly tested by acid-base titration and other methods. In addition, the content of heavy metals cannot be ignored, because it may affect the safety and quality of the product. It should be tested by atomic absorption spectroscopy and other methods to ensure that it meets strict limit requirements. Many of these Quality Standards are designed to ensure the quality of 4-bromo-2-chloropyridine, so that it can play a stable and reliable role in various fields.

4-Bromo-2-chloropyridine, with a content of 98%, requires careful attention during storage and transportation. This is an organic compound with certain chemical activity.
When storing, the first environment is dry. Moisture can easily cause chemical reactions and cause deterioration, so it is necessary to choose a dry and well-ventilated place. In the warehouse, the humidity should be controlled at a low level, and it should be kept away from water sources, sinks and other places that are prone to moisture.
Temperature is also critical. The substance may be sensitive to temperature, high temperature or accelerate decomposition, polymerization and other reactions, so it is generally suitable to store in a cool place, and the temperature is usually not more than 30 ° C.
Furthermore, because it is a chemical, the storage place needs to be isolated from oxidants, reducing agents, acids, alkalis and other substances. Such substances come into contact with it, or react violently, and even cause serious accidents such as explosions and fires.
During transportation, the packaging must be sturdy. Use packaging containers of suitable materials to prevent damage to the packaging due to vibration and collision, resulting in material leakage. Transportation vehicles should also be kept clean, free of other chemical residues, to avoid cross-contamination.
At the same time, transportation personnel must be professionally trained and familiar with the characteristics of 4-bromo-2-chloropyridine and emergency treatment methods. In the event of leakage and other situations, they can respond quickly and properly to reduce hazards. And transportation route planning should not be ignored. Sensitive areas such as water conservation areas and densely populated areas should be avoided to ensure transportation safety.