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What are the physical properties of 4-Bromo-1H-pyrrolo [2,3-b] pyridine?
4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine is a kind of organic compound. Its physical properties are quite important and it is widely used in many chemical and related fields.
Looking at its properties, under normal temperature and pressure, this compound is mostly in a solid state. Its color is usually white to light yellow powder, which is convenient for preliminary identification and determination in experiments and production scenarios.
When it comes to melting point, the melting point of 4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine is within a specific range, and this melting point data is of great significance for its purification, crystallization and identification. Knowing the melting point can help the experimenter accurately control the heating temperature and achieve precise control of the physical state transition of the compound, thus ensuring the smooth progress of the experiment and production process.
Solubility is also one of the key physical properties. The compound exhibits different solubility properties in common organic solvents. For example, in some polar organic solvents such as dimethyl sulfoxide (DMSO), it has good solubility and can be uniformly dispersed and dissolved in a certain proportion. In non-polar organic solvents, the solubility is relatively poor. This solubility characteristic has a significant impact on organic synthesis, drug development and other links. In the synthesis reaction, the appropriate choice of solvent can allow the reactants to be fully contacted according to its solubility, which can improve the reaction efficiency. In drug development, solubility is closely related to the absorption and distribution of drugs in vivo.
In addition, the density of 4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine is also a specific value. The physical property of density is indispensable when it comes to material measurement, mixing and other operations. Only by accurately knowing the density can the amount of material be accurately calculated, and the proportion of each component of the reaction system is accurate, thereby ensuring the reliability and reproducibility of experimental or production results.
In summary, the physical properties of 4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine, from appearance, melting point, solubility to density, play a crucial role in its application in chemistry and related fields.
What are the common synthesis methods of 4-Bromo-1H-pyrrolo [2,3-b] pyridine?
The common synthesis methods of 4-bromo-1H-pyrrolido [2,3-b] pyridine can be roughly divided into several types. One is to introduce bromine atoms by halogenation of nitrogen-containing heterocyclic compounds as starting materials. This process requires careful selection of halogenating reagents, such as bromine, N-bromosuccinimide (NBS), etc. If bromine is used as a halogenating agent, the control of the reaction conditions is crucial, such as the reaction temperature, reaction time, and the choice of solvent, which will have a significant impact on the reaction result. Generally speaking, under the condition of low temperature and the presence of appropriate catalysts, the reaction can be promoted in the direction of the formation of the target product.
Furthermore, the synthesis is also achieved through the strategy of constructing pyrrolido [2,3-b] pyridine rings. This approach often involves a multi-step reaction. The starting material needs to have the appropriate functional group, and the cyclization reaction gradually builds the skeleton of the target molecule. For example, small molecules containing nitrogen and carbon can be used to form the basic structure of pyrrolido [2,3-b] pyridine through reaction steps such as condensation and cyclization, and then bromine atoms can be introduced at suitable positions. In this process, each step of the reaction needs to be carefully regulated to ensure the selectivity and yield of the reaction.
Another synthesis method based on transition metal catalysis. Transition metal catalysts, such as complexes of metals such as palladium and copper, can effectively promote the coupling reaction between halogenated aromatics and nitrogen-containing heterocyclic compounds. Such methods often have the advantages of mild reaction conditions and high selectivity. However, factors such as the choice and dosage of catalysts, the design of ligands, and the structure of the reaction substrates are also critical to the smooth progress of the reaction and the generation of products. The best reaction conditions can be found through repeated experiments and optimization to achieve efficient synthesis of 4-bromo-1H-pyrrolido [2,3-b] pyridine.
Where is 4-Bromo-1H-pyrrolo [2,3-b] pyridine used?
4-Bromo-1H-pyrrolido [2,3-b] pyridine, an organic compound, is used in many fields.
In the field of pharmaceutical research and development, its application is quite extensive. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. In the process of creating many new anti-cancer drugs, 4-bromo-1H-pyrrolido [2,3-b] pyridine is often used as a starting material. After a series of chemical reactions, it can precisely construct a drug structure with the ability to target specific cancer cells, helping medicine to overcome cancer problems.
In the field of materials science, this compound also has its uses. It can be chemically modified and introduced into the photoelectric material system. Due to its conjugate structure properties, it may endow the material with unique photoelectric properties, such as for the research and development of organic Light Emitting Diode (OLED) materials, or it may improve its luminous efficiency and stability, contributing to the progress of display technology.
Furthermore, in the field of organic synthetic chemistry, 4-bromo-1H-pyrrolido [2,3-b] pyridine is an important synthetic block. Chemists can use the activity of bromine atoms to construct complex and diverse organic molecules through nucleophilic substitution, coupling and other reactions, expand the variety of organic compounds, and provide rich materials for basic research and application development of organic chemistry.
In summary, 4-bromo-1H-pyrrolido [2,3-b] pyridine has shown important application value in the fields of medicine, materials science and organic synthesis, promoting the sustainable development and progress of various fields.
What is the market price of 4-Bromo-1H-pyrrolo [2,3-b] pyridine?
4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine is an important compound in the field of organic chemistry. However, its market price is difficult to describe in a nutshell. The price is influenced by many factors, such as the difficulty of the preparation process, the cost of raw materials, the amount of market demand, the size of the production scale, and the difference in the region.
If the preparation process is complicated, the technical and equipment requirements are strict, and the required raw materials are rare and expensive, the production cost will be high, and the corresponding market price will also be high. On the contrary, if the process is simple, the raw materials are easy to obtain and cheap, and the price may be relatively low.
Market demand is also a key factor. If this compound is widely used in the pharmaceutical, electronics and other industries, the demand is strong, and the supply is limited, the price will rise. If the demand is low and the supply is excessive, the price will tend to decline.
The scale of production also affects the price. In large-scale production, due to the scale effect, the unit production cost may be reduced, and the price is expected to be more affordable. However, in small-scale production, the unit cost is higher, and the price will also rise.
Furthermore, in different regions, due to differences in economic development level, logistics cost, tax policy, etc., the price will also vary. In economically developed areas, the logistics is convenient, the competition is fierce, and the price may be relatively reasonable; in remote areas, due to the high logistics cost, the market competition is small, and the price may be slightly higher.
Taking into account various factors, it is difficult to accurately estimate the market price of 4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine. To know the exact price, you need to check the chemical product trading platform, consult relevant suppliers, or refer to professional market survey reports to obtain more accurate price information.
What are the storage conditions for 4-Bromo-1H-pyrrolo [2,3-b] pyridine?
4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine is an organic compound whose storage conditions are critical to its stability and quality.
This compound should be stored in a cool, dry and well-ventilated place. Cooling can reduce its chemical reaction rate due to excessive temperature. If the temperature is too high, it may cause it to decompose and deteriorate. A dry environment is also indispensable, because moisture easily reacts with the compound or causes it to hydrolyze, thereby damaging its structure and properties. Good ventilation can avoid the accumulation of harmful gases and maintain the safety of the storage environment.
Furthermore, the 4 - Bromo - 1H - pyrrolo [2,3 - b] pyridine should be kept away from sources of fire, heat and oxidants. This is a flammable and oxidizable substance, which may be exposed to fire and heat sources, or there is a risk of combustion or explosion; it is also easy to react violently when in contact with oxidants, endangering safety.
When storing, use a sealed container. The seal can prevent the intrusion of air, moisture and impurities, and ensure the purity and stability of the compound. And the material of the container should also be paid attention to, and it should be selected not to react with it, so as not to affect the quality of the compound.
In addition, the storage area should be clearly marked with warning signs to indicate its danger, so that contacts know that they need to be careful. At the same time, there should be complete records of storage time, conditions and storage status for traceability and management. In this way, storing according to the above conditions can ensure that the 4-Bromo-1H-pyrrolo [2,3-b] pyridine maintains good quality and stability for a certain period of time.