4-(Benzyloxy)pyridine-2(1H)-one

The chemical structure of 4- (benzyloxy) pyridine-2 (1H) -one is also one of the organic compounds. The structure of this compound contains a pyridine ring, which has a six-membered ring, the nitrogen atom in the ring occupies two positions, and the four positions on the ring are connected by a benzyloxy group. The so-called benzyloxy group is a group formed by connecting the benzyl group to the oxygen atom, and the benzyl group is composed of a benzyl group. The benzene ring is a six-membered carbon ring, which is aromatic. After being connected to the oxygen atom, it is connected to the four positions of the pyridine ring. One of the pyridine rings has a ketone group, which exists in the form of a carbonyl group (C = O) and is conjugated with the nitrogen atom on the ring. With this structure, 4- (benzyloxy) pyridine-2 (1H) -one has unique chemical properties and reactivity, and has important application potential in many fields such as organic synthesis and medicinal chemistry. It can be a key structural unit for building complex organic molecules, and because of its structural characteristics, it may exhibit specific biological activities, and may have promising performance in drug development.

4- (benzyloxy) pyridine-2 (1H) -one is an important compound in organic synthesis. The main synthesis methods are as follows:
One is to use pyridine-2 (1H) -one as the starting material. First, it is treated with an appropriate base agent to form the corresponding negative ion, and then nucleophilic substitution with benzyl halide, such as benzyl chloride or benzyl bromide. This reaction condition is mild, and it can occur smoothly in suitable organic solvents such as N, N-dimethylformamide (DMF) and acetonitrile at room temperature or slightly heated. The nitrogen atom of pyridine-2 (1H) -one is nucleophilic and can attack the benzyl carbon of benzyl halide, and the halogen ions leave to obtain the target product 4- (benzyloxy) pyridine-2 (1H) -one.
The second is converted by the functional group of the pyridine derivative. For example, a suitable substituted pyridine is selected, and a group that can be converted to a carbonyl group is introduced first at the 2-position, and then a benzyloxy group is introduced at the 4-position. A suitable leaving group, such as a halogen atom, can be introduced at the 4-position of the pyridine first, and then reacted with benzyl alcohol under basic conditions to introduce a benzyloxy group by a nucleophilic substitution reaction. Subsequently, the group in the 2-position is oxidized or other conversion reactions are carried out to change it to a carbonyl group to achieve the synthesis of 4- (benzyloxy) pyridine-2 (1H) -one.
The third reaction can be catalyzed by transition metals. Transition metals such as palladium and copper are used as catalysts to couple pyridine derivatives with benzyl derivatives. For example, pyridine derivatives containing halogen atoms and benzylboronic acid or their esters are heated in a suitable solvent in the presence of palladium catalysts, bases and suitable ligands. The transition metal catalysis system can effectively promote the formation of carbon-carbon bonds or carbon-heteroatomic bonds, and synthesize 4- (benzyloxy) pyridine-2 (1H) -one with high selectivity. The reaction conditions are relatively mild and the yield is relatively considerable.

4- (benzyloxy) pyridine-2 (1H) -ketones are useful in various fields such as medicine and materials science.
In the field of medicine, it can be used as an organic synthesis intermediate for the creation of novel drugs. Because of its pyridone structure, it is endowed with unique biological activities, or can be combined with specific biological targets to exhibit effects such as antibacterial, anti-inflammatory, and anti-tumor. In terms of antibacterial, it can inhibit bacterial growth by interfering with the key metabolic pathways or cell wall formation of bacteria; in terms of anti-tumor, it can block the signal transduction pathway of tumor cell proliferation and induce tumor cell apoptosis.
In the field of materials science, this compound can participate in the preparation of polymer materials. Due to the characteristics of benzyloxy and pyridyl ketones in the structure, the material may be endowed with special optical and electrical properties. For example, in photoelectric materials, the material may improve the charge transport efficiency and improve its luminous properties, so that the material can be applied in organic Light Emitting Diode (OLED), solar cells and other devices, helping to improve the efficiency and stability of the device.
In the field of pesticides, 4- (benzyloxy) pyridine-2 (1H) -one may have potential application value. With its biological activity, new pesticides may be developed for pest control, and compared with traditional pesticides, it may be more environmentally friendly and efficient, contributing to the sustainable development of agriculture.
In summary, 4- (benzyloxy) pyridine-2 (1H) -one has shown important application potential in many fields. With the deepening of research, it will be able to contribute to the development of various fields and create a new situation.

4- (benzyloxy) pyridine-2 (1H) -one, is one of the organic compounds. Its physical properties are as follows:
Under normal temperature, it is usually solid. The melting point of this compound is quite critical, which is related to its characteristics of thermal change. However, in order to accurately determine its melting point, it is necessary to borrow sophisticated instruments and standardized operating procedures. Generally speaking, the determination of the melting point can help to determine the purity of this compound. The higher the purity, the narrower the melting point range.
When it comes to solubility, it varies in organic solvents. In common organic solvents such as ethanol and dichloromethane, it may exhibit a certain solubility. Ethanol is a common polar organic solvent. 4- (benzyloxy) pyridine-2 (1H) -one is soluble due to its own structural characteristics, or it can form interaction forces such as hydrogen bonds with ethanol molecules. And dichloromethane, although its polarity is different from ethanol, may also interact with the compound due to its unique molecular structure, making it have a certain solubility. However, in water, due to its large proportion of hydrophobic parts in the molecular structure, its solubility is poor and it is difficult to miscible well with water molecules.
Its density is also one of the important physical properties. Density reflects the mass per unit volume of a substance, and this value is of great significance for studying the distribution and behavior of the compound in different systems. To know its exact density, rigorous experimental measurement is required, and precise control of external conditions such as temperature and pressure is indispensable during the measurement process. Due to changes in external conditions, or fluctuations in density values.
In addition, the refractive index of 4- (benzyloxy) pyridine-2 (1H) -one is also a parameter characterizing its optical properties. The refractive index is closely related to the electron cloud distribution and molecular structure of the compound molecule. Accurate determination of refractive index can be used to identify the compound or evaluate its purity, and is of great value in both qualitative and quantitative analysis of the compound.

4- (benzyloxy) pyridine-2 (1H) -one is one of the organic compounds. Its chemical properties are particularly important and are related to many chemical reactions.
This compound has aromatic rings and carbonyl groups, and its properties are active. The benzyloxy part of the aromatic ring has a specific electron cloud density distribution due to the presence of benzyl groups. In benzyloxy, the oxygen atom has lone pairs of electrons, which can be conjugated with adjacent aromatic rings, which changes the fluidity of the electron cloud in this part. In the electrophilic substitution reaction, benzyloxy groups are ortho and para-sites, and electrophilic reagents are introduced into the pyridine ring and ortho-sites. < Br >
Carbonyl groups are the key to the structure of pyridine-2 (1H) -ketones. Carbonyl groups have strong carbon-oxygen double bonds and are partially positively charged, making them vulnerable to nucleophilic attack. In case of nucleophilic reagents such as alcohols and amines, nucleophilic addition reactions can occur, forming new carbon-heteroatom bonds, resulting in ester and amide derivatives.
In addition, the pyridine ring is basic, and the lone pair electrons on the nitrogen atom can bind protons and react with acids to form salts. In organic synthesis, this property can be used to adjust the pH of the reaction system, or as a catalyst ligand to stabilize metal ions and promote metal catalytic reactions.
Because of its structural characteristics, 4- (benzyloxy) pyridine-2 (1H) -one is often a key intermediate in the field of organic synthesis. With its active reaction check point, it can construct complex organic molecular structures through various reaction paths. It has a wide range of uses in pharmaceutical chemistry, materials science and other fields.