4-(benzyloxy)pyridine 1-oxide

4- (benzyloxy) pyridine-1 -oxide is one of the organic compounds. Its main use, covering a wide range, is particularly critical in the field of organic synthesis.
First, in pharmaceutical chemistry, often used as an important intermediate. Due to its structural properties, it can be converted into biologically active compounds through many chemical reactions, or used to develop new drugs and treat various diseases.
Second, in the field of materials science, it also has its uses. Or can participate in the preparation of special materials, such as materials with specific photoelectric properties. Because of its chemical structure endowed with unique properties, or can change the molecular arrangement and interaction of materials, thereby improving the properties of materials.
Third, in the field of catalytic chemistry, it also shows potential value. It can be used as a ligand to complex with metal ions to form a high-efficiency catalyst to promote specific chemical reactions and improve reaction efficiency and selectivity.
Furthermore, in the production of fine chemicals, it can be used to synthesize various fine chemicals, such as fragrances, dyes, etc. Through ingenious synthesis paths, it can be converted into products that meet different needs, enriching the variety of chemical products.
The multi-faceted uses of this compound demonstrate its important position in the modern chemical industry and related scientific research fields, and it is an indispensable chemical substance.

There are many ways to synthesize 4- (benzyloxy) pyridine-1-oxide. First, it can be started from 4-hydroxypyridine-1-oxide. First, it is reacted with benzyl halide, such as benzyl chloride or benzyl bromide, in an alkaline environment. Commonly used bases include potassium carbonate, sodium carbonate, etc. In suitable solvents, such as N, N-dimethylformamide (DMF), acetone, etc., heating and stirring, this hydroxyl group will undergo nucleophilic substitution reaction with benzyl halide to obtain the target product 4- (benzyloxy) pyridine-1-oxide.
Furthermore, it is also possible to start from pyridine. First, pyridine is oxidized to pyridine-1-oxide with peroxides, such as m-chloroperoxybenzoic acid (m-CPBA). Subsequently, the 4-position of pyridine-1-oxide is hydroxylated, which can be achieved by suitable hydroxylating reagents. Then, the 4-hydroxypyridine-1-oxide is reacted with benzylating reagents, as above, by nucleophilic substitution to obtain 4- (benzyloxy) pyridine-1-oxide.
Another approach can be used for metal-catalyzed reactions. For example, palladium catalysis is used to react 4-halogenated pyridine-1-oxide with benzyl alcohol in the presence of a base and suitable ligands. The palladium catalyst can be selected from palladium acetate and other ligands such as tri-tert-butylphosphine. The base can be used such as cesium carbonate. Heating in a suitable solvent and metal-catalyzed coupling reaction can also successfully synthesize 4- (benzyloxy) pyridine-1-oxide. Each method has its own advantages and disadvantages, and it is necessary to choose the suitable one according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield.

4- (benzyloxy) pyridine-1 -oxide is a kind of organic compound. Its physical and chemical properties are quite important and are involved in many chemical fields.
Looking at its physical properties, under normal temperature and pressure, this compound is mostly in a solid state. Its melting point, boiling point and other properties have a great impact on its existence and form under different conditions, as well as the separation and purification process. Melting point, which is an important indicator for determining its purity, is pure 4- (benzyloxy) pyridine-1 -oxide, with a relatively fixed melting point. If impurities are contained, the melting point may decrease and the melting range may widen. The boiling point is related to its vaporization temperature under heating conditions, which is of great significance in separation operations such as distillation.
In terms of solubility, the solubility of 4 - (benzyloxy) pyridine-1 - oxides in organic solvents varies. Common organic solvents such as ethanol and dichloromethane have different solubility to them. In ethanol, or due to intermolecular forces, it can exhibit a certain solubility, which is conducive to the reaction and separation of it in the solution system.
In terms of its chemical properties, the presence of the pyridine ring in this compound gives it a certain alkalinity. The nitrogen atom of the pyridine ring can accept protons and react with acids. And the presence of benzyloxy groups makes the compound have unique reactivity. In the benzoxy group, the benzyl group can undergo reactions such as oxidation and substitution. The hydrogen atom on the pyridine ring can also participate in electrophilic substitution reactions, such as halogenation reactions, under suitable conditions. The structure of its 1-oxide affects the electron cloud distribution of the pyridine ring, thereby changing its reactivity and selectivity. In the field of organic synthesis, this compound is often used as an important intermediate, and by virtue of its physicochemical properties, it participates in the construction of a variety of complex organic compounds.

4 - (benzyloxy) pyridine-1 - oxide, the price range of this product in the market is difficult to determine. The price is determined by many factors, such as the source of materials, the simplicity of the production method, the supply and demand of the market, and even the changes of the times.
If the material is widely available and easy to obtain, the preparation method is simple, and the market demand is not abundant, the price may be inexpensive. On the contrary, if the material is thin and difficult to harvest, the production method is complicated, and there are many needs, the price will be high.
The market conditions in the past can also be used as a lesson for today. However, the market is impermanent and the price is irregular. Looking at the past, it is difficult to determine the current price. Or consult the chemical industry's merchants and industry to get the general idea. However, the price may change from time to time and change from the market, so it is difficult to give an exact price range.
Although the range of its price is not clear, it can be known how to ask for the price, or in the chemical market or online trading, consult a number of companies in detail, compare its price and measure its quality, and get a near-real price.

4 - (benzyloxy) pyridine-1 - oxide, the derivation of this substance, many related. It can be chemically reacted to obtain different products.
In terms of nucleophilic substitution, the benzyloxy group can be attacked by nucleophilic reagents, causing the benzyl group to leave and introducing a different group. If it reacts with halogenated hydrocarbons, ether derivatives can be obtained. This reaction mechanism is clear. The nucleophilic reagent is rich in electrons and tends to benzyloxy carbon, causing the benzyl group to leave in a suitable leaving ground state, and new bonds are formed.
Oxidation reactions can also be related to it. The oxides of nitrogen on the pyridine ring can be further oxidized, which can change the electron cloud density of the pyridine ring, thereby affecting its reactivity. Under certain conditions, the specific position of the pyridine ring may be oxidized to open the ring, resulting in various nitrogen-containing oxidation products.
Reduction reaction is also a derivation path. The nitrogen-oxygen bond of pyridine-1-oxide can be reduced to return nitrogen to the low-priced state. This process may change the polar and spatial structure of the molecule, resulting in products with different properties.
In addition, the benzyl group or pyridine ring of 4- (benzyloxy) pyridine-1-oxide can be modified by various organic reactions. For example, benzyl can be catalyzed by hydrogenation to remove benzyl to obtain 4-hydroxypyridine-1-oxide; pyridine rings can be electrophilically substituted to introduce substituents at specific positions to expand the types of their derivatives. These reactions, depending on the reactants and reaction conditions, have different products, which add diverse possibilities for organic synthesis.