4-AMINO-5-BROMO-2-METHYLPYRIDINE

4-Amino-5-bromo-2-methylpyridine has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Geinpyridine compounds often play an important role in the molecular structure of drugs, with unique biological activities and pharmacological properties. 4-Amino-5-bromo-2-methylpyridine can introduce various functional groups through specific chemical reactions to build drug molecules with complex structures and specific therapeutic effects. For example, in the development and preparation of some antibacterial drugs and nervous system drugs, it is often an indispensable raw material to help synthesize drugs with precise targeting and efficient therapeutic effects. < Br >
In the field of materials science, it also has important uses. Due to its molecular structure endowing special electrical and optical properties, it can be applied to the synthesis of organic optoelectronic materials. For example, in the preparation of organic Light Emitting Diode (OLED) materials, rational design and modification can improve the material's luminous efficiency, stability and color purity, thereby improving the display performance of OLED, making it shine in the display field.
In the field of pesticide chemistry, it also has a place. Pyridine derivatives are often developed as pesticides such as insecticides and fungicides. 4-Amino-5-bromo-2-methylpyridine can be used as a starting material to prepare pesticides with high inhibition and killing effects on specific pests or bacteria through a series of reactions, and because of its structural characteristics, it may reduce the impact on the environment and meet the needs of modern green pesticide development.

4-Amino-5-bromo-2-methylpyridine, this substance is in the state of white to light yellow crystalline powder. Looking at its melting point, it is between 124 ° C and 128 ° C. This property is crucial for the identification and purity determination of the substance. Its solubility is also an important physical property. It is slightly soluble in water, but soluble in common organic solvents such as ethanol and dichloromethane.
In terms of chemical stability, its properties are relatively stable under conventional conditions. When encountering strong oxidizing agents, strong acids or strong bases, chemical reactions may be triggered, resulting in changes in its structure and properties. This substance is weakly basic. Due to the presence of amino groups, it can react with acids to form corresponding salts.
In addition, due to the presence of bromine atoms and methyl groups in the molecule, it is endowed with specific reactivity. Bromine atoms can participate in nucleophilic substitution reactions, while methyl groups affect the spatial structure and electron cloud distribution of molecules, and play a role in their chemical behavior and physical properties. These physical properties are of great significance in the field of organic synthesis, drug development, and many other aspects, providing a foundation for related research and applications.

The synthesis method of 4-amino-5-bromo-2-methylpyridine, through the ages, many parties have their own wonderful methods.
First, take 2-methylpyridine as the initial material and go through the bromination step. In a suitable reaction vessel, add an appropriate amount of 2-methylpyridine, followed by a suitable solvent, such as dichloromethane, and then slowly add a brominating reagent, such as N-bromosuccinimide (NBS), control the reaction temperature in the low temperature range, about 0-10 ° C. When stirring the reaction number, 5-bromo-2-methylpyridine can be obtained. Then, the product is placed in another reaction system, and an amination reagent, liquid ammonia or ammonia water are added. Under high temperature and pressure conditions, 4-amino-5-bromo-2-methylpyridine is obtained.
Second, there are also 2-methyl-4-nitropyridine as the starting material. It is first brominated, similar to the above bromination step, under appropriate solvents and conditions, bromine atoms are introduced to obtain 5-bromo-2-methyl-4-nitropyridine. Subsequently, the product is reduced by a method, commonly used reducing agents such as iron and hydrochloric acid, or hydrogen and catalysts (such as palladium carbon), to convert the nitro group into an amino group to obtain 4-amino-5-bromo-2-methylpyridine.
Third, there is a synthesis method, which is to use 2-methyl-5-halopyridine as the starting material (the halogenated group can be chlorine, bromine, etc.). After nitrification, in a suitable mixed acid system (mixture of nitric acid and sulfuric acid), control the temperature and reaction time to obtain 2-methyl-4-nitro-5-halopyridine. Then, through the substitution reaction of halogen atoms, the halogen atoms are replaced by brominating reagents. After the reduction step, similar to the previous method, the nitro group is reduced to an amino group, and the final product is 4-amino-5-bromo-2-methylpyridine. These several synthesis methods have their own advantages and disadvantages, and they need to be selected according to specific needs and conditions.

4-Amino-5-bromo-2-methylpyridine is a chemical substance. When storing and transporting, many matters must be paid attention to.
Store first. This substance should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can avoid chemical changes caused by excessive temperature, and avoid adverse reactions such as decomposition and polymerization. A dry place can prevent it from getting damp. If it gets damp, it may damage its purity, affect subsequent use, or even cause chemical reactions, resulting in danger. Well-ventilated, it can disperse harmful gases that may be volatile in time, and keep the storage environment safe.
Furthermore, it should be stored separately from oxidizing agents, acids, alkalis and other substances. This is because 4-amino-5-bromo-2-methylpyridine is chemically active and in contact with the above substances, it is easy to cause violent chemical reactions, or risk of combustion and explosion. And the storage place should be equipped with suitable materials to contain the leakage, so as to prevent accidental leakage and deal with it in time, so as not to pollute the environment and reduce the degree of harm.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is safe. The packaging is complete to prevent it from leaking due to collision and vibration during transportation. The loading is safe, and it can avoid dumping, rolling and other conditions during transportation, which can damage the packaging and lead to material leakage. When transporting, also follow the prescribed route, away from sensitive areas such as densely populated areas and water sources. If a leak occurs during transportation, emergency measures must be taken immediately, evacuate the surrounding people, isolate the leakage area, and quickly report to the relevant departments to properly handle it according to professional guidance. In this way, the storage and transportation of 4-amino-5-bromo-2-methylpyridine can be guaranteed.

The market price range of 4-amino-5-bromo-2-methylpyridine is difficult to determine due to many reasons. Looking at past market conditions, the price of this compound is often affected by supply and demand, manufacturing, and raw material prices.
If the supply exceeds the demand, the price may drop; on the contrary, if the demand exceeds the supply, the price will rise. The refinement of the manufacturing process increases the yield and decreases the cost, and the price may fall; the fluctuation of raw material prices also deeply affects the price.
In chemical markets, the price of such compounds varies from tens of gold to hundreds of gold per kilogram. If the quality is high and the purity is very high, the price may be higher; if you buy it in bulk, there may be a discount, and the price is also different from retail.
And its price varies according to the territory of the city. In developed places, the price may vary due to prosperous demand and convenient logistics. And the market situation is changing rapidly. If you want to know the real-time price, you should consult the chemical raw material supplier, browse the professional chemical website or the trading platform involved in this, and you can get a near-real price.