4-amino-3-iodopyridine

4-Amino-3-iodopyridine, which is 4-amino-3-iodopyridine, has a wide range of uses and is particularly critical in the field of medicinal chemistry.
First, it is used to create new antibacterial drugs. Many bacteria are gradually resistant to common antibacterial agents, so it is urgent to develop new antibacterial drugs. 4-amino-3-iodopyridine can be used as a key intermediate, and compounds with unique antibacterial mechanisms can be constructed by organic synthesis. In its molecular structure, amino and iodine atoms give special chemical activity, which can precisely act on specific targets of bacteria and interfere with the normal physiological metabolism of bacteria to achieve antibacterial effect.
Second, it also has important uses in the research and development of anti-tumor drugs. Cancer diseases pose a serious threat to human health, and the search for high-efficiency and low-toxicity anti-tumor drugs is a research hotspot. 4-Amino-3-iodopyridine may interact with specific biomacromolecules of tumor cells due to its structural properties, such as embedding DNA double strands, which affects DNA replication and transcription of tumor cells, thereby inhibiting tumor cell proliferation and inducing apoptosis.
Furthermore, it has also emerged in the field of materials science. With the development of science and technology, the demand for special functional materials is increasing. 4-Amino-3-iodopyridine can be modified and polymerized appropriately, or materials with special electrical and optical properties can be prepared. For example, its iodine atoms exist or can change the electronic cloud distribution of the material, giving the material unique optoelectronic properties, which can be used to manufacture organic Light Emitting Diodes, sensors and other optoelectronic devices.
In addition, in terms of pesticide chemistry, 4-amino-3-iodopyridine can be used to synthesize new pesticides. For agricultural pests and diseases, it is crucial to design and synthesize pesticides with high selectivity and low toxicity. Pesticides synthesized from it may specifically act on specific targets of pests or pathogens, effectively prevent and control agricultural pests, and have little impact on the environment and non-target organisms, which is in line with the needs of modern green agriculture development.

4-Amino-3-iodopyridine is an organic compound whose physical properties are particularly important for the application and properties of this substance. It is described in detail as follows:
From its appearance, it is often solid, which is caused by intermolecular forces, so that it remains solid at room temperature and pressure. Its color is mostly white to light yellow, which is due to the absorption and reflection properties of molecular structures.
The melting point is about 140-145 ° C. When the temperature rises to the melting point, the molecule gains enough energy to overcome the lattice energy, the lattice structure disintegrates, and the substance changes from solid to liquid. This melting point value is related to the intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., which together affect the melting point.
In terms of boiling point, due to the relative molecular weight and intermolecular forces of the compound, it is about 340-350 ° C. At this temperature, the kinetic energy of the molecule increases significantly, which is sufficient to overcome the intermolecular forces in the liquid phase and transform into the gas phase.
Solubility is also a key property. 4-amino-3-iodopyridine has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This is because these organic solvents and the compound molecules can form similar intermolecular forces, following the principle of "similar miscibility". The solubility in water is relatively poor, due to the difference in the type and strength of the intermolecular forces between water and the compound.
The density is about 2.06 g/cm ³. This value reflects the mass per unit volume of the substance and is closely related to the molecular structure, which affects its distribution and behavior in the mixture.
In addition, the compound has certain stability, but due to the activity of amino and iodine atoms, under certain conditions, such as high temperature, strong acid, strong base environment or when encountering specific reagents, chemical reactions may occur, which may affect its physical properties.
In summary, the physical properties of 4-amino-3-iodopyridine, such as appearance, melting point, boiling point, solubility, density, etc., are determined by its molecular structure, and these properties have a profound impact on its application in chemical synthesis, drug development, and many other fields.

The synthesis of 4-amino-3-iodopyridine has always been an important topic in organic synthetic chemistry. There are many methods, and each has its advantages and disadvantages. Today, I will describe several common methods in detail.
First, pyridine is used as the starting material, and iodine atoms are introduced through halogenation reaction. Pyridine can be reacted with iodine and appropriate oxidants, such as hydrogen peroxide or periodic acid, in a specific solvent, such as glacial acetic acid or dichloromethane, at a suitable temperature and reaction time, to generate 3-iodopyridine. Then, 3-iodopyridine is aminated. 4-Amino-3-iodopyridine is obtained by nucleophilic substitution of 3-iodopyridine with ammonia or an organic amine in the presence of a catalyst such as copper under high temperature and pressure.
Second, 4-aminopyridine is used as the starting material to introduce iodine atoms through a halogenation reaction. This reaction usually requires a suitable solvent, such as tetrahydrofuran or dimethylformamide, and a suitable halogenating agent, such as N-iodosuccinimide (NIS), at low temperature and in the presence of a base. The base can be selected from potassium carbonate or triethylamine, etc., which can guide the iodine atom to selectively enter the 3-position to obtain the target product 4-amino-3-iodopyridine.
Third, the cross-coupling reaction catalyzed by transition metals can be used. For example, with 4-halopyridine (e.g. 4-chloropyridine or 4-bromopyridine) and an iodine source, such as cuprous iodide, in the presence of transition metal catalysts such as palladium or nickel and suitable ligands such as bis (diphenylphosphine) ethane (dppe) or 2-dicyclohexylphosphine-2 ', 6' -dimethoxybiphenyl (SPhos), under the action of a suitable solvent and base, a coupling reaction occurs to introduce iodine atoms, and then through the amination step, 4-amino-3-iodopyridine is obtained.
The above synthesis methods each have their own applicable scenarios and conditions. In actual operation, it is necessary to choose carefully according to many factors such as the availability of raw materials, the difficulty of reaction, cost and yield.

4-Amino-3-iodopyridine is a unique organic compound with considerable applications in various fields.
In the field of medicinal chemistry, it plays a key role. The unique structure of the geinpyridine ring with amino and iodine atoms endows the compound with excellent biological activity. It can be used as a drug intermediate to help synthesize a variety of biologically active molecules. For example, modified by specific chemical reactions, it may be able to create drugs with high affinity and selectivity for specific disease targets. For some abnormal signaling pathways related to cancer, drugs synthesized based on this may be precisely blocked and inhibit the proliferation and spread of cancer cells. Or for neurological diseases, with its structural properties, the development of drugs that can modulate neurotransmitter transmission and repair nerve damage.
In the field of materials science, 4-amino-3-iodopyridine is also useful. Due to the introduction of iodine atoms, its electrical and optical properties are unique. It can participate in the preparation of new photoelectric materials, such as intermediates of organic Light Emitting Diodes (OLEDs). Its unique electronic structure may optimize the luminous efficiency and stability of OLEDs, promoting display technology to a higher level. In the development of solar cell materials, or with its structural advantages, it can improve the efficiency of light absorption and charge transfer, contributing to the development of clean energy.
In the field of organic synthetic chemistry, this compound is an important building block for the construction of complex organic molecules. Amino and iodine atoms can initiate multiple chemical reactions, such as nucleophilic substitution, coupling reactions, etc. By ingeniously designing reaction paths, chemists can use 4-amino-3-iodopyridine as the starting material to construct organic molecules with complex structures and unique functions, greatly expanding the boundaries of organic synthesis and injecting new vitality into the development of organic chemistry.

4-Amino-3-iodopyridine is one of the organic compounds. In today's chemical and pharmaceutical fields, its market prospects are quite promising.
From a chemical perspective, this compound is an important synthesis intermediate. It can be converted into a variety of high-value-added fine chemicals through various chemical reactions. For example, in the synthesis of new materials, 4-amino-3-iodopyridine can participate in the construction of special molecular structures, giving the material unique physical and chemical properties, such as enhancing the stability and conductivity of the material. With the rapid development of materials science, the demand for materials with special properties is increasing day by day, and the market demand for 4-amino-3-iodine pyridine as a key raw material for synthesis will also increase.
In the field of medicine, the potential of this compound cannot be underestimated. Numerous studies have shown that pyridine compounds containing iodine and amino groups often have significant biological activities. 4-amino-3-iodine pyridine may be used as a lead compound, and new drugs can be developed through structural modification and optimization. Today, the pharmaceutical industry has a strong desire for innovative drugs to deal with various difficult diseases. The unique chemical structure of 4-amino-3-iodopyridine makes it very likely to become an important starting material for the development of new antibacterial and anticancer drugs. Therefore, with the deepening of pharmaceutical research and development, its application prospects in the pharmaceutical market are extremely broad.
Furthermore, considering from the market supply and demand level, although its current output may not reach a very high scale, with the gradual release of downstream industry demand, its production scale is expected to gradually expand. Production technology has also been continuously optimized, and costs may be reduced, thereby enhancing its market competitiveness. In this way, both the chemical industry's demand for it as an intermediate and the pharmaceutical industry's demand for it as a potential drug raw material will promote the continued expansion of the 4-amino-3-iodopyridine market.
In summary, 4-amino-3-iodopyridine has great development potential in the chemical and pharmaceutical fields, and its market prospects are promising. Over time, it will surely emerge in related industries and occupy an important position.