4-amino-3-bromo-5-nitropyridine

4-Amino-3-bromo-5-nitropyridine is an important chemical substance in the field of organic synthesis. Its main uses are widely involved in many aspects of medicine, pesticides and materials science.
In the field of medicine, it is often used as a key intermediate to synthesize drug molecules with specific biological activities. Due to the unique combination of amino, bromine atoms and nitro groups in its structure, it has the ability to participate in a variety of chemical reactions and can construct complex molecular structures that are closely integrated with biological targets, so it is important for the development of new antibacterial, antitumor and antiviral drugs.
In the field of pesticide creation, 4-amino-3-bromo-5-nitropyridine is also indispensable. Through its participation in organic synthesis reactions, pesticide varieties with high-efficiency killing effects on pests or regulating effects on crop growth can be prepared. Its structural properties help to enhance the interaction between pesticides and specific enzymes or receptors in target organisms, improve the activity and selectivity of pesticides, and then reduce the impact on the environment.
In the field of materials science, this compound can be used to synthesize organic materials with special photoelectric properties. After rational molecular design and modification, materials constructed with 4-amino-3-bromo-5-nitropyridine may exhibit unique fluorescence, electrical conductivity and other properties, and show application potential in organic Light Emitting Diode (OLED), organic solar cells and other fields.
In summary, 4-amino-3-bromo-5-nitropyridine, with its unique chemical structure, plays a key role in the fields of medicine, pesticides and materials science, and contributes significantly to the progress and development of related industries.

The common methods for synthesizing 4-amino-3-bromo-5-nitropyridine are as follows.
First, pyridine is used as the starting material. The pyridine is first nitrified to introduce the nitro group into the specific position of the pyridine ring. This step requires careful selection of nitrifying reagents and reaction conditions to achieve ideal regioselectivity. Commonly used nitrifying reagents, such as a mixed acid system of concentrated nitric acid and concentrated sulfuric acid, react at a suitable temperature to locate the nitro group at the 3rd or 5th position of the pyridine ring. Subsequent bromination reactions are carried out. Bromine and appropriate catalysts can be used to introduce bromine atoms into the target position. Finally, the amino group is introduced into the pyridine ring through a suitable amination reaction to complete the synthesis of 4-amino-3-bromo-5-nitropyridine.
Second, pyridine derivatives can also be used as starters. If the starter already contains some target substituents, the rest can be gradually constructed through specific reactions. For example, if the starter contains bromine atoms, nitro and amino groups can be introduced in sequence through nitrification, amination and other reactions. In this process, the reaction conditions of each step need to be carefully regulated to ensure the smooth progress of the reaction and avoid side reactions.
Furthermore, the coupling reaction strategy of transition metal catalysis can also be used. First, pyridine derivative fragments containing specific substituents are prepared, and then these fragments are coupled through transition metal catalysis to realize the synthesis of 4-amino-3-bromo-5-nitropyridine. Commonly used transition metals such as palladium and copper can provide more accurate synthesis paths, but they require high reaction conditions and reagents.
When synthesizing this compound, it is necessary to choose a reasonable synthesis method according to the actual situation, considering the availability of raw materials, the difficulty of reaction operation, cost and other factors, in order to achieve the purpose of efficient synthesis.

4-Amino-3-bromo-5-nitropyridine, this substance is a kind of organic compound. Its physical properties are quite important and relevant to its application in many fields.
Looking at its appearance, it usually shows a white to yellow crystalline powder shape, which is easy to identify and preliminarily determine with the naked eye. Its melting point is in a specific range, about [X] ° C. The melting point is the inherent property of the substance, which is of great significance for the identification and identification of its purity. When heated to this temperature, the substance changes from solid to liquid state, and the temperature point of this phase transition process is stable and iconic.
Furthermore, solubility is also a key physical property. In common organic solvents, such as ethanol, dichloromethane, etc., it exhibits a certain solubility. In ethanol, under specific temperature and concentration conditions, it can dissolve to form a homogeneous solution. This property makes it possible to achieve specific purposes by solvent selection in organic synthesis reactions and product separation and purification processes. In water, its solubility is relatively limited, which is related to the polarity of functional groups contained in the molecular structure and the overall molecular polarity. The interaction of pyridine ring, amino group, bromine atom and nitro group makes it less hydrophilic than small molecule compounds with stronger polarity.
In addition, the stability of 4-amino-3-bromo-5-nitropyridine is also a physical property consideration. In a dry environment at room temperature and pressure, it can maintain a relatively stable state, and its structure and chemical properties are not easy to change. However, in case of extreme conditions such as high temperature, high humidity or strong light irradiation, the chemical bonds in the molecular structure may be affected, triggering decomposition or other chemical reactions, and the study of stability is of great significance to its storage and transportation.
The above physical properties, such as appearance, melting point, solubility and stability, are all indispensable key information in chemical research, chemical production and related fields, which profoundly affect the synthesis, storage, transportation and practical use efficiency of the substance.

4-Amino-3-bromo-5-nitropyridine has unique chemical properties and is worth exploring. In this compound, the amino group (-NH ²) has a certain electron donating property and can participate in many reactions. Because of its lone pair of electrons on the nitrogen atom, it is easy to bind with protons and is alkaline to a certain extent. In an acidic environment, it can protonate to form salts.
Bromine atom (-Br) is a halogen atom with high chemical activity. Under appropriate conditions, nucleophilic substitution reactions can occur, such as reactions with nucleophiles, such as alkoxides, amines, etc., bromine atoms can be replaced by corresponding groups to form new compounds, thereby expanding the chemical derivation path of the substance.
Nitro (-NO ³) is a strong electron-absorbing group, which reduces the electron cloud density of the pyridine ring, making it more difficult to occur electrophilic substitution reactions on the ring. However, it can be converted into amino groups through reduction reactions, which provides the possibility for further derivatization of the compound. For example, under the action of suitable reducing agents, nitro can be gradually reduced to nitroso and hydroxylamine groups, and finally amino groups are formed, thereby changing the electron distribution and reactivity of the molecule.
In addition, the pyridine ring of 4-amino-3-bromo-5-nitropyridine itself has aromatic properties, and the stable conjugate system makes it have special chemical stability and reactivity. Under certain conditions, the pyridine ring can undergo reactions such as addition and substitution, interact with other substituents on the ring, and derive a variety of chemical reaction paths, providing a rich material basis and reaction model for the field of organic synthesis.

4-Amino-3-bromo-5-nitropyridine is in the market, and its price range is difficult to determine. The price of this chemical often changes for various reasons. First, the source and quality are the main factors. If it is produced from a famous factory, of high quality and purity, the price may be high; if the source of impurities is secondary, the price should drop. Second, the situation of supply and demand also affects its price. If the market demand is large and the supply is small, the price will rise; if the supply exceeds the demand, the price will fall. Third, the difficulty of preparation is also related to the price. The synthesis of this product involves complicated steps, the materials used are rare, the cost increases and the price is high; if it is easy to make, the price can be cheap. < Br >
In the past, it seemed that the price per gram was between tens of yuan and hundreds of yuan. However, the market of chemical industry is changing, and the recent market may vary. If you want to confirm the price, you can visit the chemical trading network and supplier inquiry office to find out the real-time price.