4 Amino 3 Bromo 5 Iodopyridine
pyridine pyrrole pyrazine piperidine piperazine

4-Amino-3-bromo-5-iodopyridine

    Specifications

    HS Code

    307557

    Chemical Formula C5H4BrIN2
    Molecular Weight 309.907
    Appearance Solid (likely a powder or crystalline solid, color may vary based on purity)
    Solubility In Water Low solubility, as it is an organic heterocyclic compound with non - polar groups (the pyridine ring and halogen atoms)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate due to its organic nature
    Pka The amino group may have a pKa value in the range of 9 - 11 (approximate for pyridine - based amines)
    Stability Stable under normal conditions, but sensitive to strong reducing agents, oxidizing agents, and high - energy radiation due to the presence of halogens and the amino group

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    General Information
    Where to Buy 4-Amino-3-bromo-5-iodopyridine in China?
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    Frequently Asked Questions

    As a leading 4-Amino-3-bromo-5-iodopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Amino-3-bromo-5-iodopyridine?
    4-Amino-3-bromo-5-iodopyridine is an important intermediate in organic synthesis. In the field of medicinal chemistry, it has a wide range of uses. It is often used to construct compounds with specific biological activities, paving the way for the creation of new drugs. Due to the unique reactivity of amino, bromine and iodine atoms in its structure, it can be cleverly connected with other functional groups through various chemical reactions, and then a series of drug molecules with novel structures can be derived.
    In the field of materials science, 4-amino-3-bromo-5-iodopyridine has also emerged. It can be used as a building block to participate in the preparation of organic materials with special optoelectronic properties. Its unique molecular structure endows materials with unique electrical and optical properties, and it is expected to be applied to cutting-edge fields such as organic Light Emitting Diodes and solar cells, contributing to material innovation.
    Furthermore, in the fine chemical industry, this compound is used as a key raw material for the synthesis of fine chemicals with special functions. With carefully designed reaction routes, it can be converted into various high-value-added products, such as special dyes, fragrances and high-performance additives, to help upgrade fine chemical products.
    In summary, 4-amino-3-bromo-5-iodopyridine, with its unique structure and reactivity, plays an indispensable role in many fields such as medicine, materials, and fine chemicals, promoting technological progress and innovation in various fields.
    What are 4-Amino-3-bromo-5-iodopyridine synthesis methods?
    The common methods for synthesizing 4-amino-3-bromo-5-iodopyridine include the following.
    First, pyridine is used as the starting material. Pyridine is first aminylated, and an amino group can be introduced into the pyridine ring through a suitable nucleophilic substitution reagent. Subsequently, bromine atoms are introduced at specific locations using brominating reagents, such as bromine or N-bromosuccinimide (NBS). Finally, iodine atoms are introduced using an iodizing reagent, such as potassium iodide in combination with an appropriate oxidizing agent. This process requires precise control of reaction conditions, such as temperature, reaction time, and the amount of reagents, to ensure that the reaction can selectively replace at the target position. < Br >
    Second, start from the pyridine derivative containing the desired substituent. If a pyridine derivative with some target substituents can be found, the target molecule can be constructed by selective functional group transformation. For example, if there are pyridine derivatives containing amino and bromine groups, iodine atoms can be introduced at specific positions through suitable iodine substitution reactions. During the reaction, attention should be paid to selecting suitable reaction solvents, bases and catalysts to promote the smooth progress of the reaction and improve the purity and yield of the product.
    Third, the coupling reaction catalyzed by transition metals. Transition metal catalysts such as palladium and copper can be used to couple pyridine substrates containing amino groups with bromine and iodine substitutes. Such reactions usually have high selectivity and efficiency, but the reaction system needs to be carefully optimized, including the type and dosage of metal catalysts, the selection of ligands, the type of bases, etc., to achieve efficient synthesis of 4-amino-3-bromo-5-iodopyridine. And in the post-treatment stage of the reaction, suitable separation and purification methods, such as column chromatography, need to be used to obtain high-purity products.
    What are the physical properties of 4-Amino-3-bromo-5-iodopyridine?
    4-Amino-3-bromo-5-iodopyridine is a kind of organic compound. Its physical properties are quite critical and it has applications in chemical, pharmaceutical and other fields, so it is important to clarify its properties.
    The appearance of this compound is often white to light yellow crystalline powder. Looking at its color and shape are the main points of preliminary identification. Under normal temperature and pressure, this material is relatively stable, and it may decompose under extreme conditions such as hot topics and open flames, which releases toxic gases such as hydrogen bromide, hydrogen iodide and nitrogen oxides.
    When it comes to solubility, 4-amino-3-bromo-5-iodopyridine is slightly soluble in water. This property makes it difficult to disperse in large quantities in water, but it has relatively good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). In organic solvents, its molecules interact with solvent molecules to achieve a certain degree of dispersion and dissolution, which is of great significance for many chemical reactions, because many organic reactions need to be carried out efficiently in homogeneous systems.
    Furthermore, the melting point is also one of its important physical properties. Its melting point is about a certain range (the specific value may vary slightly due to different experimental conditions). The determination of the melting point can not only be used to identify the purity of the compound, but also indicate its state change under different temperature conditions. When the temperature rises near the melting point, the compound will change from solid to liquid state, and this state change needs to be carefully considered in the process of material processing, pharmaceutical preparation, etc.
    The physical properties of 4-amino-3-bromo-5-iodopyridine, such as appearance, stability, solubility and melting point, are interrelated and affect its performance in various practical application scenarios. It is of great value in research and production practice in related fields.
    4-Amino-3-bromo-5-iodopyridine in what areas
    4-Amino-3-bromo-5-iodopyridine is useful in various fields. In the field of medicinal chemistry, it is a key synthetic building block. Based on it, a variety of biologically active compounds can be prepared, such as antibacterial, antiviral and anti-cancer drugs. Due to its unique chemical structure, it can precisely bind to specific targets in organisms, thus achieving the effect of treating diseases.
    In the field of materials science, 4-amino-3-bromo-5-iodopyridine can also be used. It can be used to prepare functional materials, such as optoelectronic materials. Due to its specific functional groups, the material is endowed with special optical and electrical properties, which may have potential applications in the preparation of organic Light Emitting Diode (OLED) and solar cells, which can optimize device performance and improve efficiency.
    Furthermore, in the field of organic synthetic chemistry, it is an important reaction intermediate. With its structural characteristics, it can participate in many organic reactions, such as coupling reactions, substitution reactions, etc. With this, complex organic molecular structures can be constructed, providing an effective way for the synthesis of new organic compounds, promoting the development of organic synthetic chemistry, and expanding the types and functions of compounds.
    What is the market outlook for 4-Amino-3-bromo-5-iodopyridine?
    4-Amino-3-bromo-5-iodopyridine, this is an organic compound. Looking at its market prospects, many factors are intertwined.
    In the field of medicine, organic compounds are often key intermediates in drug synthesis. At present, the research and development of innovative drugs continues to advance, and the demand for intermediates with unique structures is increasing. 4-Amino-3-bromo-5-iodopyridine may find a place in the creation of new drugs due to its specific chemical structure. If a pharmaceutical company develops a new drug with a specific mechanism of action, such bromine, iodine and aminopyridine units may be required in its structure to achieve the desired pharmacological activity, which will generate demand for this compound.
    In the field of materials science, with the development of electronic and optical materials, organic compounds with special optoelectronic properties have attracted much attention. The structure of the pyridine derivative may endow it with unique optoelectronic properties, or it may be used to prepare organic Light Emitting Diodes (OLEDs), solar cells and other materials. With the expansion of the market size of such materials, the potential demand for 4-amino-3-bromo-5-iodine pyridine may also rise.
    However, its market prospects also pose challenges. The difficulty and cost of synthesizing this compound may exist. If the synthesis steps are complicated and the yield is poor, it will lead to high production costs and limit its large-scale application. And the market competition situation also needs to be considered. If there are many similar or alternative compounds, 4-amino-3-bromo-5-iodopyridine wants to seize market share, it must highlight its own advantages.
    Overall, 4-amino-3-bromo-5-iodopyridine has potential opportunities in the fields of medicine and materials science. However, it is necessary to overcome the problems of synthesis and competition in order to seek broad development space in the market.