4-Amino-3-bromo-2-chloropyridine

4-Amino-3-bromo-2-chloropyridine is an important intermediate in organic synthesis. It has a wide range of uses and has made great contributions to the field of medicinal chemistry.
The unique structure of 4-amino-3-bromo-2-chloropyridine allows it to participate in a variety of chemical reactions to construct complex medicinal active molecules. For example, or with other compounds containing specific functional groups, through condensation, substitution and other reactions, derivatives with novel structures can be obtained. These derivatives may show good effects on the treatment of specific diseases, such as antibacterial, anti-inflammatory, and anti-tumor genera.
In the field of pesticide chemistry, it is also a key raw material. In today's agriculture, there is a growing demand for high-efficiency, low-toxicity and environmentally friendly pesticides. 4-Amino-3-bromo-2-chloropyridine can be synthesized into pesticide ingredients with unique mechanisms of action through a series of reactions. It can precisely act on the specific physiological processes of pests, or interfere with the nervous system of pests, or inhibit their growth and development, achieving the purpose of effective pest control, while having little impact on the environment and non-target organisms.
Furthermore, in the field of materials science, although the application is slightly inferior to the first two, it also has potential. Or can participate in the synthesis of special functional materials, such as photoelectric materials. Its structural properties or endow materials with unique optical and electrical properties, which contribute to the development of materials science.
Overall, 4-amino-3-bromo-2-chloropyridine, with its unique chemical structure, is an indispensable and important substance in many fields such as medicine, pesticides, and materials science. It is of great significance to promote technological progress and development in various fields.

There are several methods for synthesizing 4-amino-3-bromo-2-chloropyridine. One method is to take pyridine as the starting material first, and use halogenation to act on the pyridine ring in sequence with a brominating agent and a chlorinating agent. If liquid bromine and pyridine are mixed in a suitable solvent, supplemented by a catalyst, and the temperature and reaction time are controlled, 3-bromo-pyridine can be obtained. Next, under specific reaction conditions, 3-bromo-2-chloropyridine is further chlorinated with a chlorinating agent, such as chlorine gas or a chlorination reagent, to obtain 3-bromo-2-chloropyridine. Finally, the amination reagent, such as ammonia derivatives or other amino-containing reagents, is reacted with 3-bromo-2-chloropyridine, and 4-amino-3-bromo-2-chloropyridine is obtained through the substitution process.
In the second method, the pyridine can be aminated first to obtain 4-aminopyridine. Later, bromine and chlorine atoms are introduced at specific positions of 4-aminopyridine by bromination and chlorination. However, this process needs to pay attention to the control of the reaction conditions at each step to prevent the growth of side reactions. When brominating, the appropriate brominating agent and reaction environment need to be selected so that the bromine atoms fall accurately at the target position. The same is true of chlorination. After precise regulation, 4-aminopyridine is gradually converted into 4-amino-3-bromo-2-chloropyridine.
There are other pyridine derivatives as starting materials, and the synthesis of 4-amino-3-bromo-2-chloropyridine can also be achieved through a series of functional group conversion and modification. However, no matter what method, the reaction conditions and reagent selection need to be carefully considered to obtain satisfactory yield and purity. Each step of the reaction needs to consider the influence of temperature, solvent, catalyst and other factors, so that the reaction proceeds according to the expected path to form the synthesis of this compound.

4-Amino-3-bromo-2-chloropyridine is one of the organic compounds. Its physical and chemical properties are worth studying in detail.
Looking at its physical properties, at room temperature, this substance is mostly in a solid state, but the exact physical form may vary depending on the preparation method and purity. The genera of its melting point and boiling point are very important for the identification and separation of this compound. Sadly, there is no detailed data to give exact values. However, with similar pyridine derivatives, the melting point may be between tens and hundreds of degrees Celsius, and the boiling point should also be at a higher temperature. The presence of pyridine rings enhances the intermolecular force.
As for solubility, 4-amino-3-bromo-2-chloropyridine may have a certain solubility in organic solvents, such as dichloromethane, ethanol, etc. Due to the fact that it has both polar amino groups and halogen atoms in its molecules, it can dissolve with some organic solvents by intermolecular forces. The solubility in water may be limited. Due to the hydrophobicity of the whole molecule, the pyridine ring and halogen atoms dominate.
On its chemical properties, the presence of amino groups makes this compound alkaline. The nitrogen atom of the amino group has lone pairs of electrons, which can accept protons and react with acids to form salts. And the amino group is also a nucleophilic group, which can participate in many nucleophilic substitution reactions. Halogen atoms, i.e. bromine and chlorine, are highly active. Under appropriate conditions, nucleophilic substitution can occur, providing the possibility for the introduction of other functional groups. For example, when reacting with nucleophiles such as alkoxides and amines, halogen atoms can be replaced to construct more complex organic molecular structures.
And because of the conjugated system of the pyridine ring, 4-amino-3-bromo-2-chloropyridine has certain stability. At the same time, this conjugated system also affects the distribution of its electron cloud, making the reaction check point activity on the pyridine ring different. In the electrophilic substitution reaction, the localization effect of the substituent needs to be carefully considered.

The price of 4-amino-3-bromo-2-chloropyridine in the market often varies due to many reasons, and it is difficult to be sure. Looking at the market conditions in the past, the price of such fine chemicals depends on their purity, supply sources, and market supply and demand.
If its purity is extremely high, it can reach the high-grade purity required for experimental research, and the price may be very high. Because of its difficulty in preparation, the process requirements are strict, and the cost is high, the price also rises. Or tens of gold to more than a hundred gold per gram.
However, if the purity is only suitable for general industrial use, the price should be slightly reduced. However, it also depends on the supply and demand of the market. If the supply exceeds the demand, the merchant sells the goods, or reduces the price to sell, and the price may be reduced to a few gold per gram. If the demand exceeds the supply, even for industrial grade ones, the price will rise, or to more than ten gold per gram.
The distance of the supply source and the cost of logistics also have an impact. If the supply is close, the cost is saved, and the price may be slightly lower; if it is shipped from a long distance, plus the cost of logistics, the price may increase.
To sum up, the price of 4-amino-3-bromo-2-chloropyridine in the market depends on the purity, supply and demand, and supply sources. The price per gram may be more than a few gold to a few hundred gold, which is difficult to generalize.

4-Amino-3-bromo-2-chloropyridine is a kind of organic compound. Its storage conditions are crucial and related to the quality and stability of this compound.
Store this compound in a cool place. Cover it in a cool place, the temperature is relatively low, which can slow down its chemical reaction rate. If it is exposed to high temperature, the molecular movement intensifies, and it is easy to cause the compound to decompose and deteriorate. If the sun is like fire on a hot summer day, if this compound is exposed to high temperature, its structure may be damaged and its function will be lost. Therefore, choose a cool place, such as a shady warehouse, and the indoor temperature should be maintained at 15-25 degrees Celsius, so that it can be kept stable.
Next time, a dry environment is required. Moisture is the enemy of many compounds, and 4-amino-3-bromo-2-chloropyridine is no exception. Moisture can easily trigger hydrolysis reactions, breaking chemical bonds of compounds. If the storage place is filled with water vapor, if it is placed in a water town, the rate of hydrolysis will increase. Therefore, when placed in a dry place, a desiccant can be prepared on the side of the storage container to absorb the surrounding water vapor and maintain the dryness of the environment.
Furthermore, this material should be sealed and stored. All kinds of gases in the air, such as oxygen, carbon dioxide, etc., may react chemically with 4-amino-3-bromo-2-chloropyridine. Sealed, it can prevent the intrusion of air. For example, in a closed glass bottle, the bottle mouth is sealed with wax or rubber stopper, which can prevent air from penetrating and protect the compound.
In addition, the storage place should be away from fire sources and oxidants. This compound may be flammable and dangerous in case of fire, and the oxidant is prone to oxidation reaction with the like, causing its properties to change. Therefore, it should be placed away from the fire source and should not be stored in a chamber with the oxidant to avoid the risk of accidents. In this way, by adhering to the general principles of storage, 4-amino-3-bromo-2-chloropyridine can be maintained for a long time without losing its properties.