4-Amino-2-hydroxypyridine

4 - Amino - 2 - hydroxypyridine is an organic compound with unique chemical properties, which are detailed as follows:
1. ** Acid and basic **: This compound is amphoteric because it contains amino groups (\ (- NH_ {2}\)) and hydroxyl groups (\ (-OH\)). Amino groups can bind protons and are alkaline; hydroxyl groups can dissociate protons under certain conditions and are acidic. In different acid-base environments, it can exist in different ionic forms, affecting its solubility and reactivity. For example, in acidic solutions, the amino group is easily protonated and becomes a positively charged ammonium ion (\ (- NH_ {3 }^{+}\)）； in alkaline solutions, the hydroxyl group can lose protons and generate negatively charged oxygen negative ions (\ (- O ^{-}\)）。
2. ** Nucleophilic **: The nitrogen atom of the amino group has a lone pair of electrons, so that 4-Amino-2-hydroxypyridine has nucleophilicity, which can attack the electrophilic reagents and participate in nucleophilic substitution. Like in some halogenated hydrocarbon reactions, the nitrogen atom of the amino group will attack the carbon atom of the halogenated hydrocarbon, and the halogen atom will leave, thus forming a new carbon-nitrogen bond.
3. ** Coordination ability **: With the lone pair electrons on nitrogen and oxygen atoms, this compound can be used as a ligand to coordinate with metal ions to form complexes. This property is widely used in the fields of catalysis and materials science. For example, after coordinating with transition metal ions, it may change the electron cloud density and spatial structure of metal ions, which may affect the catalytic activity and optical properties of the complexes.
4. ** tautomerism **: Due to the existence of movable protons and double bonds in the molecule, 4-Amino-2-hydroxypyridine can undergo tautomerism. There are mainly enol and keto tautomerism, which will affect its chemical properties and reaction paths. Under certain reaction conditions, the ratio of enol to ketone will change, and the active intermediates participating in the reaction will also vary due to tautomerism.
5. ** Conjugation Effect **: The pyridine ring forms a conjugated system with amino and hydroxyl groups, and the electron cloud is delocalized throughout the molecule. This enhances the stability of the molecule, and also affects the electron cloud density of each atom, which changes the physical and chemical properties of the compound. For example, the presence of a conjugated system affects the absorption spectrum of the compound, so that it has an absorption peak at a specific wavelength, which can be used for analytical detection.

4-Amino-2-hydroxypyridine is an organic compound with a wide range of uses in many fields. Its common uses are as follows:
First, in the field of medicine, this compound has a wide range of uses. Because of its specific chemical structure and biological activity, it is often a key intermediate in drug development. By modifying and modifying its structure, a variety of compounds with pharmacological activities can be created, such as antibacterial, anti-inflammatory and anti-tumor drugs. For example, in the synthesis of some new antibacterial drugs, 4-Amino-2-hydroxypyridine is used as the starting material, and through a series of chemical reactions, a drug molecule with high inhibitory effect on specific pathogens is constructed.
Second, in the field of materials science, 4-Amino-2-hydroxypyridine also has important applications. Because it contains amino and hydroxyl groups, it can participate in many polymerization reactions and is used to prepare functional polymer materials. For example, polymerization with specific monomers can generate polymers with special optical and electrical properties, which are very useful in optoelectronic materials, sensors, etc. Such polymer materials can be applied to organic Light Emitting Diodes (OLEDs) to improve their luminous efficiency and stability; they can also be used as sensor-sensitive materials for highly sensitive detection of specific substances.
Third, in the field of agriculture, 4-Amino-2-hydroxypyridine can be used as a raw material for pesticide synthesis. After chemical transformation, pesticide products with insecticidal, bactericidal or herbicidal activities are made, which can help crop pest control and weed control, and ensure agricultural production. For example, after the development of new herbicides, 4-Amino-2-hydroxypyridine can produce herbicides that can precisely inhibit weed growth and are safe for agricultural crops after a series of reactions.
Fourth, in the field of organic synthesis, 4-Amino-2-hydroxypyridine, as an important intermediate, can participate in the construction of many complex organic molecules. Due to its unique chemical activity, it can react with a variety of reagents such as nucleophilic substitution and electrophilic substitution, providing the possibility for the synthesis of organic compounds with diverse structures and promoting the development of organic synthesis chemistry.

4-Amino-2-hydroxypyridine is also an organic compound. Its synthesis method has been studied by chemists throughout the ages, and there are many methods.
First, pyridine is used as the starting material. Introduce protective groups into the appropriate position of pyridine to prevent interference from other check points during the reaction. Then, through nitrification, introduce nitro groups into the pyridine ring. This process requires careful temperature control and reaction conditions. Due to the high activity of nitrification, side reactions are prone to occur. After obtaining nitropyridine derivatives, nitro groups are converted into amino groups by reduction. Commonly used reducing agents such as iron and hydrochloric acid, hydrogen and catalysts, etc. After the hydroxylation reaction, the hydroxyl group is introduced at a suitable position, which can be achieved by means of nucleophilic substitution. Although this route is slightly complicated, the raw materials are easy to obtain, and the reaction conditions are not extremely harsh, it is often the choice for synthesis.
Second, natural products or simple derivatives containing pyridine rings are used as the starting materials. For example, some plant extracts or specific pyridine derivatives have some of the required functional groups in their structures, and only need to be modified. After appropriate functional group conversion reactions, such as acylation, hydrolysis, oxidation-reduction, etc., the structure of the target molecule is gradually constructed. This approach may reduce the reaction steps and improve the synthesis efficiency because the starting material has a certain structural basis, but the source of the starting materials may be limited, depending on the situation.
Third, the heterocyclic synthesis strategy is used. By multi-component reaction, small molecule compounds containing atoms such as nitrogen and oxygen are constructed in one step under suitable catalyst and reaction conditions, and amino and hydroxyl groups are introduced at the same time. This kind of reaction has high atomic economy and simple steps. However, it requires high reaction conditions and catalysts, and requires fine regulation to obtain the ideal yield.
This method has its own advantages and disadvantages. During the synthesis, chemists should weigh the choices according to the actual needs, raw material availability, cost and reaction conditions to achieve the purpose of efficient and economical synthesis of 4-amino-2-hydroxypyridine.

4-Amino-2-hydroxypyridine is in the market, and its price range is difficult to determine. This is due to the complex market conditions, and the price varies with many factors.
Looking at the market conditions of the past, the source of materials, the state of demand and supply, and the progress of manufacturing are all the main reasons. If the material is abundant, the production is convenient, and the supply exceeds the demand, the price may decrease. On the contrary, if the material is rare, it is not easy to make, and the demand exceeds the supply, the price will rise.
And it is very useful in various fields such as chemical industry and medicine. In chemical industry, it is an essential material for synthesis; in medicine, or the development of drugs. The wide range of uses also makes its price affected. < Br >
Based on past market conditions, the price per kilogram may range from a few hundred to several thousand yuan. However, this is only a guess, not an exact number. The market is like flowing water, changing rapidly. To know the exact price, you need to consult the real-time quotation of chemical material suppliers and cities before you can get it.

4 - Amino - 2 - hydroxypyridine is an organic compound with specific chemical properties. Its storage conditions are quite important, which is related to the stability and quality of this substance.
According to its characteristics, it should be stored in a cool place. This is because the temperature is too high, or the molecular movement is intensified, triggering a chemical reaction and causing it to deteriorate. And it must be dry and protected from humid environments. Because moisture is prone to reactions such as hydrolysis, the structure and purity of the compound are damaged.
Furthermore, it should be placed in a well-ventilated place. This can prevent the accumulation of harmful gases, keep the storage environment safe, and prevent it from reacting with components in the air.
When stored, it should also be separated from oxidants, acids, etc.
In summary, 4-Amino-2-hydroxypyridine should be stored in a cool, dry and ventilated place, and isolated from oxidants and acids, so as to ensure its quality and stability, and play its due role in subsequent use.