4-amino-2-bromopyridine

4-Amino-2-bromopyridine is also an organic compound. It has a wide range of uses and is an important synthetic intermediate in the field of medicinal chemistry. In the research and development of medicine, it is often necessary to construct compounds with specific structures. Due to its unique chemical structure, 4-amino-2-bromopyridine can participate in various reactions and assist in the formation of biologically active drug molecules.
In the field of pesticide chemistry, it also has key uses. It can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal properties through specific chemical reactions. Because of its structure, it can be precisely designed, making pesticides highly selective and efficient for specific target organisms, and reducing the impact on non-target organisms.
In addition, it is also involved in the field of materials science. It can be used to prepare organic materials with special photoelectric properties. Because of its nitrogen, bromine and other atoms, it endows the material with a unique electronic structure. In the research and development of organic Light Emitting Diodes, solar cells and other materials, it may improve the performance of materials such as charge transport and luminous efficiency.
In short, 4-amino-2-bromopyridine, with its special chemical structure, is an indispensable and important substance in many fields such as medicine, pesticides, and materials science, promoting technological progress and innovation in various fields.

The synthesis of 4-amino-2-bromopyridine has been investigated in the past. One method is to use 2-bromopyridine as the starting material and nitrate to obtain 2-bromo-4-nitropyridine. This step requires the selection of suitable nitrifying reagents, such as mixed acid (a mixture of nitric acid and sulfuric acid), at a specific temperature and reaction time. Due to the structural characteristics of 2-bromopyridine, the bromine atom is an ortho-para-position group. Although the electron cloud density of the benzene ring is reduced, the nitro group can still be mainly introduced into the 4-position after adjusting the reaction conditions.
Then, 2-bromo-4-nitropyridine is reduced to obtain 4-amino-2-bromopyridine. There are various reduction methods. The most common method is catalytic hydrogenation, and a suitable catalyst, such as palladium carbon (Pd/C), is selected to react in a hydrogen atmosphere. Or a chemical reduction method, such as a system composed of iron powder, zinc powder and other metals and acids, such as hydrochloric acid-iron powder system, through this reduction step, the nitro group is then converted into an amino group.
Another way is to use 2-aminopyridine as the starting material and obtain the target product through bromination reaction. In this bromination reaction, bromine or N-bromosuccinimide (NBS) can be selected as brominating reagents. If bromine is used, it is often necessary to react in an appropriate solvent, such as dichloromethane, at low temperature and in the presence of a catalyst. The catalyst can promote the polarization of bromine molecules, making it easier for bromine positive ions to attack the pyridine ring. If NBS is used, the reaction conditions are relatively mild, which can avoid excessive bromination and make it easier to control the reaction process, resulting in the preparation of 4-amino-2-bromopyridine.

4-Amino-2-bromopyridine is one of the organic compounds. Its physical properties are quite specific, let me tell them one by one.
Looking at its morphology, under room temperature and pressure, 4-amino-2-bromopyridine often takes a white to light yellow crystalline powder shape. This morphology is easy to observe and process, and is also the basis for its characteristics in many chemical reactions.
As for the melting point, it is about 127-131 ° C. The melting point is an inherent property of the substance. This specific melting point range allows 4-amino-2-bromopyridine to change from solid to liquid in a specific temperature range when heated. This property is of great significance for purity detection and reaction conditions control in organic synthesis and other fields.
In terms of solubility, 4-amino-2-bromopyridine is slightly soluble in water. This solubility characteristic is closely related to its molecular structure. The existence of pyridine rings, coupled with the substitution of amino and bromine atoms, changes the polarity of the molecule, so it is only slightly soluble in water. However, it exhibits good solubility in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. This property provides many possibilities for its solvent selection in organic synthesis reactions. In dichloromethane, it can be uniformly dispersed, which is conducive to sufficient contact and collision between reaction molecules, and then promotes the smooth progress of the reaction; in DMF, with good solubility, it can exist stably and participate in various complex chemical reactions.
In addition, 4-amino-2-bromopyridine has certain stability. When it encounters strong oxidants, strong acids or strong bases, its chemical structure may change. During storage and use, care should be taken to avoid contact with such substances to prevent deterioration.
This physical property makes 4-amino-2-bromopyridine important in the fields of medicine, pesticides and materials science. For example, in the field of medicine, due to its unique physical and chemical properties, it can be used as a key intermediate to participate in the synthesis of many drugs.

In the market of chemical raw materials, the price of 4-amino-2-bromopyridine is not fixed, but is influenced by many factors.
First, the price change of raw materials has a great impact on it. If the price of starting materials required for the synthesis of this compound, such as pyridine and its derivatives, or brominating agents, aminating agents, etc., rises, the production cost will increase, and the price of 4-amino-2-bromopyridine will also increase. On the contrary, the price of raw materials decreases, and the price of products may also have room for downward adjustment.
Second, the difference in preparation process is also related to cost and selling price. Advanced and efficient processes can improve product yields, reduce energy consumption and waste output, thus reducing unit costs and providing greater flexibility in market pricing. If the process is outdated, the yield is low and the cost is high, the product price may be high.
Third, the balance between market supply and demand is a key factor. If the market demand for 4-amino-2-bromopyridine is strong, such as the pharmaceutical industry, the demand for it as an intermediate increases sharply, and the supply is relatively insufficient, the price will rise. On the contrary, if the market is oversupplied and the demand is low, the price will fall under pressure.
Fourth, the regional distribution of manufacturers and the competitive situation are also affected. Different regions may have different product prices due to differences in labor costs, transportation costs, etc. And there are many manufacturers. When the competition is fierce, in order to seize market share, the price may tend to decline; if the market monopoly is strong, the price may remain at a high level.
Overall, its market price fluctuates frequently, often due to the dynamic changes of the above factors. If buyers want to know the real-time price, they need to communicate closely with suppliers or refer to the latest quotation information of the chemical product trading platform.

4-Amino-2-bromopyridine is an organic compound. During storage and transportation, many matters need to be paid attention to.
First stability and reactivity. This compound may be sensitive to heat, and it is easy to decompose when heated, causing danger. Therefore, it should be stored in a cool place, away from heat sources and open flames. And it has certain chemical activity, or reacts with oxidants, acids, etc., and must be stored separately from such substances to prevent accidents.
Second words storage conditions. It needs to be sealed and stored, because it may interact with moisture and oxygen in the air. Placed in a dry and well-ventilated place, it can avoid moisture and deterioration, and can also prevent the accumulation of harmful gases. Storage containers should also be suitable, and corrosion-resistant materials should be selected, such as glass or specific plastic containers, to prevent the container from reacting with compounds.
During transportation, it is necessary to follow relevant regulations and standards. Proper packaging, protection with buffer materials, to prevent packaging damage caused by collision. And the transportation environment should also be controlled to maintain suitable temperature and humidity to avoid extreme conditions. Transport personnel should be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and properly in the event of an accident.
In short, the storage and transportation of 4-amino-2-bromopyridine is related to safety and quality. All links need to be treated with caution and operated according to specifications to avoid danger and loss.