4 Amino 2 6 Dibromopyridine
pyridine pyrrole pyrazine piperidine piperazine

4-Amino-2,6-dibromopyridine

    Specifications

    HS Code

    139126

    Chemical Formula C5H4Br2N2
    Molar Mass 251.907 g/mol
    Appearance Solid
    Color Off - white to light yellow
    Melting Point 148 - 152 °C
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in polar organic solvents like DMSO, DMF
    Pka The amino group has a pKa around 5 - 6 (approximate, for the conjugate acid)
    Stability Stable under normal conditions but can react with strong oxidizing and reducing agents, also sensitive to moisture over long - term storage

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    General Information
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    Frequently Asked Questions

    As a leading 4-Amino-2,6-dibromopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Amino-2,6-dibromopyridine?
    4-Amino-2,6-dibromopyridine is an important member of organic compounds. It has a wide range of uses and is mostly used as a key intermediate in the synthesis of drugs in the field of medicinal chemistry. When developing new antimicrobial drugs, this compound can be ingeniously introduced into the molecular structure of the drug through a series of chemical reactions, giving the drug unique antibacterial activity and providing a strong help to overcome the problem of bacterial infection.
    In the field of materials science, it also plays an important role. It can participate in the preparation of materials with special photoelectric properties, such as in the field of organic Light Emitting Diode (OLED). By means of structural modification and chemical reaction, the luminous characteristics of the material can be regulated, the luminous efficiency and color purity of OLED can be improved, and the image quality of the display device can be clearer and brighter.
    In addition, in terms of pesticide chemistry, 4-amino-2,6-dibromopyridine can be used as a raw material for synthesizing high-efficiency and low-toxicity pesticides. After rational design and reaction, the prepared pesticide can accurately act on pests, effectively control crop diseases and pests, ensure a bumper grain harvest, and have little impact on the environment, which is in line with the needs of green agriculture development. In short, due to its unique structure and chemical properties, this compound has important application value in many fields, promoting the continuous progress and development of related industries.
    What are the physical properties of 4-Amino-2,6-dibromopyridine?
    4-Amino-2,6-dibromopyridine is also an organic compound. It has unique physical properties and is worth exploring.
    In terms of its properties, under room temperature, it often shows a white-like to light yellow crystalline powder. Looking at it, the color is uniform and the texture is fine. This morphology is conducive to its full contact and reaction with other substances in many chemical reactions, laying the foundation for the synthesis of specific products.
    As for the melting point, it is about 175-179 ° C. The characteristics of the melting point are extremely critical for the identification, purification and application of substances. Based on this melting point, the purity of the substance can be determined by the method of melting point determination. If the melting point of the sample is similar to the standard melting point and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting point deviation is large and the melting range is wide, the purity is not good and needs to be further purified.
    In terms of solubility, 4-amino-2,6-dibromopyridine is slightly soluble in water. For water, common solvents are also common solvents. The poor solubility of this compound in water is due to the characteristics of its molecular structure. The interaction between the groups in the molecule and water molecules is weak, so it is difficult to dissolve in water. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, with its good solubility, it can be used for extraction, separation and other operations; after being dissolved in DMF, it can participate in some specific organic synthesis reactions, and the excellent solubility and relatively stable chemical properties of DMF can promote the smooth progress of the reaction.
    In addition, the stability of 4-amino-2,6-dibromopyridine is also considerable. Under normal environmental conditions, it can maintain the stability of its own chemical structure and is not prone to spontaneous decomposition, polymerization and other reactions. When exposed to extreme chemical environments such as strong oxidants, strong acids or strong bases, its structure may be affected and corresponding chemical changes will occur.
    These physical properties are interrelated and jointly determine the application mode and scope of 4-amino-2,6-dibromopyridine in many fields such as organic synthesis and drug development, which are of great significance to chemical research and industrial production.
    What is the chemical synthesis method of 4-Amino-2,6-dibromopyridine?
    The chemical synthesis of 4-amino-2,6-dibromopyridine is a key research in the field of organic synthesis. This compound has important uses in many fields such as medicinal chemistry and materials science.
    In the past, the synthesis of 4-amino-2,6-dibromopyridine often used pyridine as the starting material. The pyridine is first brominated, and bromine atoms are introduced at the 2nd and 6th positions of the pyridine ring. The commonly used brominating reagent is bromine (Br ²). In the presence of suitable catalysts such as iron powder or iron tribromide, bromine can react efficiently with pyridine to form 2,6-dibromopyridine. This reaction requires attention to the control of reaction conditions, such as temperature, ratio of reactants, etc., to improve the yield and purity of 2,6-dibromopyridine.
    Then, the amination reaction of 2,6-dibromopyridine is performed. The common amination method is to react with 2,6-dibromopyridine with ammonia gas or an amino-containing reagent. With the assistance of an appropriate base and catalyst, the amino group can replace the bromine atom on the pyridine ring to form the target product 4-amino-2,6-dibromopyridine. This step also requires careful regulation of the reaction conditions to ensure that the reaction proceeds in the desired direction and avoids the occurrence of side reactions.
    There is another synthetic way, which can start from other nitrogen-containing heterocyclic compounds and gradually construct the structure of 4-amino-2,6-dibromopyridine through a series of functional group transformation. However, no matter what method, it is necessary to comprehensively consider many factors such as reaction conditions, raw material cost, yield and product purity in order to achieve an efficient and economical synthesis goal.
    What are the precautions for 4-Amino-2,6-dibromopyridine in storage and transportation?
    4-Amino-2,6-dibromopyridine is a class of organic chemicals. When storing and transporting, many matters must be paid attention to.
    First words storage. This chemical should be placed in a cool and dry place. Because of the cool environment, it can slow down the rate of its chemical change. If it is exposed to high temperature, it may cause a reaction and cause it to deteriorate. A dry environment is also important, because moisture may react with it. For example, some substances containing amino groups are easily hydrolyzed in water, so it is crucial to avoid moisture. And it must be sealed and stored to prevent contact with oxygen, carbon dioxide and other gases in the air. Oxygen may cause oxidation, and carbon dioxide may react with it, damaging its quality.
    Further transportation. When handling, be sure to handle it with care. This chemical may have a certain sensitivity. If it is subjected to violent vibration or impact, it may be dangerous, such as causing an explosion and other extreme conditions. The transportation tool should also be clean and dry, and there should be no other chemical residues to avoid cross-reaction with it. At the same time, the transportation process should ensure that the temperature is relatively stable and avoid large temperature fluctuations.
    In addition, whether it is storage or transportation, it is necessary to strictly follow the relevant safety norms and regulations. Operators should also be familiar with its nature and safety precautions, and wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to ensure safety. In this way, the safe and secure storage and transportation of 4-amino-2,6-dibromopyridine can be achieved.
    What are the safety risks associated with 4-Amino-2,6-dibromopyridine?
    4-Amino-2,6-dibromopyridine is an organic compound, and its associated safety risks need to be discussed in detail.
    Those who bear the brunt of it may be irritating. If it comes into contact with the skin, it may cause skin discomfort, such as redness, itching, or even rash. If it is not carefully entered into the eyes, it will cause damage to the eyes, cause pain, redness, and swelling, and in severe cases, affect vision.
    In the respiratory tract, inhalation of its dust or volatile gaseous substances can irritate the respiratory tract, causing cough, asthma, and people who are sensitive to the respiratory tract are more susceptible to respiratory discomfort symptoms.
    Furthermore, 4-amino-2,6-dibromopyridine also has a latent risk in the environment. When it degrades in the natural environment, it may generate harmful metabolites, which affect the ecological balance and cause harm to soil and water organisms.
    When handling this object, it must be fully protected. Operators should wear protective clothing, gloves and protective glasses to avoid skin-to-eye contact. Operate in a well-ventilated place, preferably in a fume hood to prevent inhalation. In case of inadvertent contact, skin contamination should be rinsed with plenty of water immediately; in eye contact, rinse quickly with running water and seek medical attention immediately.
    In addition, the waste of this compound cannot be discarded at will, and it needs to be properly disposed of in accordance with relevant regulations to reduce the harm to the environment. Only by fully understanding and following safety procedures can the safety risks posed by 4-amino-2,6-dibromopyridine be effectively avoided.