4-Amino-2,3,5,6-tetrafluoropyridine

4-Amino-2,3,5,6-tetrafluoropyridine is a crucial intermediate in the field of organic synthesis and has a wide range of uses in many fields.
First, in the field of medicinal chemistry, it can be used to create new antibacterial drugs. The unique structure of this pyridine derivative can effectively act on specific targets of bacteria, interfere with normal physiological activities of bacteria, and hinder their growth and reproduction. For example, by modifying its structure, specific antibacterial drugs against drug-resistant bacteria can be developed, providing a new way to solve the increasingly serious problem of bacterial resistance.
Second, in the field of pesticide chemistry, 4-amino-2,3,5,6-tetrafluoropyridine can be used as a key raw material to prepare high-efficiency, low-toxicity and environmentally friendly pesticides. After rational molecular design and synthesis, the prepared pesticide can precisely act on the specific physiological process of pests, achieve efficient pest control, and reduce the impact on non-target organisms, which is in line with the development needs of modern green pesticides.
Third, in the field of materials science, this compound can be used to synthesize functional materials with special properties. Due to the presence of pyridine rings and fluorine atoms, the synthesized materials may have unique electrical, optical and thermal properties. For example, luminescent materials for organic Light Emitting Diodes (OLEDs) can be prepared to improve the luminous efficiency and stability of the device; high-performance polymer materials can also be synthesized to enhance the mechanical properties and chemical stability of the material.
In summary, 4-amino-2,3,5,6-tetrafluoropyridine has shown important application value in the fields of medicine, pesticides and materials due to its unique structure and properties. With the continuous progress of science and technology, its application prospects will be broader.

4-Amino-2,3,5,6-tetrafluoropyridine is a key intermediate in the field of organic synthesis, and is used in the synthesis of many fine chemical products such as pesticides and medicines. The synthesis method is as follows:
1. ** Aminolysis of halogenated pyridine **: Halogenated pyridine is used as the starting material and obtained by substitution reaction with ammonia. For example, 2,3,5,6-tetrafluoropyridine and liquid ammonia under specific pressure and temperature, and in the presence of a catalyst, the amino group in the ammonia molecule will replace the halogen atom to form 4-amino-2,3,5,6-tetrafluoropyridine. This method is relatively easy to obtain raw materials, and the reaction route is not complicated, but the reaction conditions are relatively harsh, high temperature and high pressure are required, and the equipment requirements are relatively high.
2. ** Nitration Reduction Method of Pyridine Derivatives **: The pyridine derivative is first nitrified, and the nitro group is introduced into the pyridine ring, and then the nitro group is reduced to an amino group. For example, first nitrate 2,3,5,6-tetrafluoropyridine to obtain a nitro-containing intermediate, and then use a suitable reducing agent, such as hydrogen in the presence of catalysts (such as palladium carbon, etc.), or use chemical reducing agents (such as iron powder, zinc powder, etc.) under acidic conditions to reduce the nitro group to an amino group, and finally obtain the target product. This method has a little more steps, but each step is relatively mild and the yield is considerable.
3. ** Heterocyclic construction method **: Using nitrogen-containing and fluorine-containing small molecules as raw materials, pyridine rings are constructed by multi-step reaction. For example, through specific fluoronitrile compounds and nitrogen-containing reagents, under alkali catalysis, pyridine rings are formed by cyclization reaction, and amino groups are introduced at the same time. Although this method has a wide range of raw materials, the reaction process is quite complicated, and the control of reaction conditions is extremely high, requiring fine regulation of each step of the reaction.

4-Amino-2,3,5,6-tetrafluoropyridine is a kind of organic compound. Its physical and chemical properties are unique, and it has important research and application value.
Looking at its physical properties, under normal temperature and pressure, 4-amino-2,3,5,6-tetrafluoropyridine is often white to light yellow crystalline powder. Its melting point is quite high, about 100 ° C - 105 ° C. This characteristic makes it able to maintain a stable solid state at ordinary ambient temperatures, and it is not easy to melt or evaporate due to minor changes in temperature. Furthermore, its solubility is also unique. It is slightly soluble in water, but it can be better dissolved in organic solvents such as dichloromethane, N, N-dimethylformamide, etc. This difference in solubility is related to the amino and fluorine atoms contained in the molecular structure. The amino group has a certain polarity, while the electronegativity of the fluorine atom is very strong, resulting in a change in the overall polarity of the molecule, so it exhibits such solubility characteristics.
In terms of its chemical properties, the amino groups of 4-amino-2,3,5,6-tetrafluoropyridine are more active and can participate in a variety of chemical reactions. For example, it can react with acid chloride to form corresponding amide compounds. This reaction is based on the nucleophilicity of the amino group and the electrophilicity of the carbonyl carbon of the acyl chloride. The two interact to achieve chemical transformation. At the same time, due to the existence of fluorine atoms on the pyridine ring, the electron cloud density of the pyridine ring decreases, making the nucleophilic substitution reaction on the pyridine ring more likely to occur. The electron-absorbing induction effect of the fluorine atom prompts the electron cloud on the pyridine ring to shift to the fluorine atom, which enhances the positive electricity of the pyridine ring carbon atom and makes it more vulnerable to the attack of nucleophilic reagents. This compound is often used as a key intermediate in the field of medicinal chemistry to construct many biologically active molecular structures, providing an important material basis for the development of new drugs.

Wen Jun wants to know the price range of 4-hydroxy-2,3,5,6-tetrafluoropyridine in the market. This compound, in the field of chemical industry, has a wide range of uses, but its price often changes for many reasons.
If its quality is good, and the preparation method is fine, and it is suitable for market supply and demand, its price may be relatively easy. In general, the price of this 4-hydroxy-2,3,5,6-tetrafluoropyridine per gram may be between tens of yuan and more than 100 yuan.
However, if the price of raw materials rises sharply, or the preparation process changes, resulting in a significant increase in costs, its price will also rise. And if the market supply is less than demand, the demand is large and the goods are scarce, the price is also high, or more than 200 yuan per gram.
On the contrary, if the market supply is full and the demand is weak, and the merchant wants to sell his goods quickly, the price may fall below tens of yuan per gram. In short, its price often fluctuates with the supply and demand of the market, the price of raw materials, and the difficulty of preparation, etc. It is difficult to determine the exact value. If you want to know the exact price, you can consult the merchant of chemical raw materials, or visit a professional chemical trading platform, to get the current exact price.

4-Hydroxy-2,3,5,6-tetrafluoropyridine is an extremely critical organic compound, which is widely used in many fields such as medicine and pesticides. Its storage conditions are crucial, which is related to the stability and quality of the compound.
This compound should be stored in a cool, dry and well-ventilated place. Humidity can easily make 4-hydroxy-2,3,5,6-tetrafluoropyridine absorb moisture or cause chemical reactions to cause it to deteriorate. A cool environment can effectively slow down its chemical reaction rate. If the temperature is too high, it may cause its decomposition or other adverse reactions.
Furthermore, keep away from fire, heat and oxidants. 4-Hydroxy-2,3,5,6-tetrafluoropyridine is flammable to a certain extent, in case of open flames, hot topics or the risk of combustion and explosion. The oxidizer will also react violently with the compound, threatening storage safety.
Storage containers should not be ignored, and corrosion-resistant materials should be selected, such as glass or specific plastic containers. 4-Hydroxy-2,3,5,6-tetrafluoropyridine has certain chemical activity, or reacts with some metal containers, affecting its quality.
In addition, clear warning signs should be set in the storage area, and irrelevant personnel should be strictly prohibited from approaching, and the storage area should be equipped with corresponding fire equipment and leakage emergency treatment equipment to deal with possible unexpected situations. < Br >
Follow the above storage conditions to ensure the stability and safety of 4-hydroxy-2,3,5,6-tetrafluoropyridine during storage, providing reliable quality assurance for subsequent use.