4-(6-Fluoropyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

4- (6-cyanopyridine-3-yl) -6- (2-furyl-2-methylethoxy) pyridine [1,5-a] pyridine-3-formaldehyde, what is the main use of 3-methylpyridine in this substance?
3-methylpyridine is an important raw material for organic synthesis and has a wide range of uses. First, in the field of medicine, it can be used as an intermediate for the synthesis of various drugs. For example, the preparation of many antibacterial and anti-inflammatory drugs requires this as the starting material, and through a series of chemical reactions, the core structure of the drug is constructed to achieve the expected pharmacological effect. Second, in terms of pesticides, 3-methylpyridine can derive many high-efficiency pesticide ingredients. It can participate in the synthesis of pesticides, fungicides, etc. With its special chemical structure, it can poison and inhibit pests and bacteria, ensure the healthy growth of crops, and increase yield. Third, in the fragrance industry, because of its unique chemical properties, it can be properly modified and transformed to prepare various unique aroma fragrance ingredients, adding pleasant aroma to food, cosmetics, etc. Fourth, in the field of materials science, it can be used as a monomer or additive for the preparation of certain high-performance materials. By polymerizing or compounding with other compounds, the properties of materials such as mechanical properties and thermal stability can be improved, and the application scenarios of materials can be expanded. In summary, 3-methylpyridine plays a key role in many fields and is an indispensable raw material for the development of modern industry and scientific research.

To prepare 3-methylbutyric acid, 4- (6-pentenyl-3-carbonyl) -6- (2-furyl-2-acetoxy) pentene and [1,5-a] pentene and 3-methyl have many synthetic paths, and each has its own advantages and disadvantages. The following are common methods:
First, isobutyraldehyde and malonic acid are used as raw materials, and 2-methyl-2-butenic acid can be obtained by Knoevenagel condensation reaction, followed by catalytic hydrogenation to obtain 3-methylbutyric acid. The raw materials in this way are easy to purchase, and the reaction conditions are mild. However, the steps are slightly complicated, and the reaction process needs to be carefully controlled. The specific process is: isobutyric aldehyde and malonic acid are mixed in an appropriate solvent, and an organic base such as piperidine is used as a catalyst, heated and refluxed to produce 2-methyl-2-butenic acid. The key to this step is to control the amount of catalyst and the reaction temperature. If the amount of catalyst is too high or the temperature is too high, it is easy to cause side reactions to occur. Subsequent 2-methyl-2-butenic acid is placed in the presence of a suitable hydrogenation catalyst such as palladium carbon, and hydrogen is introduced for hydrogenation, and the target product 3-methylbutyric acid can be obtained. The hydrogenation reaction requires attention to hydrogen pressure, reaction temperature and catalyst activity to ensure the efficient progress of the reaction.
Second, 3-methylbutyric acid is prepared by oxidation reaction with 3-methylbutanol as raw material. Commonly used oxidants include potassium dichromate-sulfuric acid, potassium permanganate, etc. Taking potassium dichromate-sulfuric acid as an example, 3-methylbutanol is slowly added to the mixture of potassium dichromate and sulfuric acid to control the temperature for oxidation reaction. The steps of this method are simple, but potassium dichromate and other oxidants are highly toxic, and a large amount of chromium-containing wastewater is produced, which is complicated to deal with and does not match the concept of green chemistry. In this process, potassium dichromate is highly oxidizing under acidic conditions and can oxidize alcohol hydroxyl groups to carboxyl groups. However, the reaction is severe, and the dripping speed and temperature need to be strictly controlled to prevent excessive oxidation to form other by-products. After the reaction is completed, the reaction solution is separated and purified to obtain pure 3-methylbutyric acid.
Third, using isobutyronitrile as raw material, first hydrolyze to isobutyric acid, and then methylate to obtain 3-methylbutyric acid. During hydrolysis, isobutyronitrile coheats with acid or base and converts to isobutyric acid. Methylation step, select suitable methylating reagents such as iodomethane, and react with isobutyric acid under alkaline conditions. This path involves two important reactions of nitrile hydrolysis and methylation, and the reaction conditions of each step need to be precisely regulated. In the hydrolysis reaction, the concentration of acid and base, the reaction temperature and time have a great influence on the degree of hydro During the methylation reaction, the methylation reagent has high activity, and the operation needs to be cautious. The alkaline conditions also need to be properly controlled, otherwise the yield and purity of the product will be affected.

"Tiangong Kaiwu" said: "Everything in the genus of alkane has its own characteristics, and the genus of ethyl genus is also different. Today, ethane has a unique quality."
Ethane, under room temperature and pressure, is a colorless and odorless gas. Its shape is like a light cloud, floating in the air, difficult to touch. Its density is slightly lighter than that of air, so it always rises above. Its melting and boiling point is quite low, with a melting point of about -183.3 ° C and a boiling point of -88.6 ° C, which makes it mostly gaseous in ordinary environments.
And ethane is extremely insoluble in water, just like mutual exclusion with water. However, in organic solvents, it can be slightly soluble, like a fish getting water, which is the characteristic of its solubility.
When it comes to chemical properties, ethane is quite stable. Under normal conditions, it is like a humble gentleman, and it is not easy to react with others. In case of fire, it will transform into a fierce person, burn violently, release a huge amount of heat, generate carbon dioxide and water, and resemble a grand fireworks show. If under certain conditions, such as light, it encounters chlorine gas, and a substitution reaction will also occur. For example, when a dancer changes his posture on the stage, chlorine atoms replace hydrogen atoms one by one, and many new substances will be derived.
This is the physical and chemical properties of ethane, which between heaven and earth, with its unique nature, deduce the wonderful changes of matter.

Guan Jun's question is about "the price of 3-methyl butyraldehyde in the market". However, this question is quite complicated. Due to the unpredictable market conditions, the price is affected by many factors.
First, the supply of raw materials is of great significance. The preparation of 3-methyl butyraldehyde requires constant raw materials. If the raw materials are abundant, the preparation cost may be slightly reduced, which in turn affects the market price. On the contrary, raw materials are scarce, and the cost will rise, and the price will also rise.
Second, the quality of the preparation process also affects. The exquisite process can improve output efficiency, reduce energy consumption, and make the cost lower, and the price may be more affordable. If the process is crude, inefficient, and expensive, the price will remain high.
Third, the amount of market demand is the key factor. If there is strong demand for 3-methyl butyraldehyde in many industries, the supply is in short supply, and the price is bound to go up. If there is little demand and oversupply, the price will go down.
Fourth, the market competition situation should not be underestimated. There are many manufacturers in the market, and the competition is fierce. In order to compete for share, there may be price cuts. On the contrary, if the market is monopolistic, the manufacturers may control the price.
As for the exact price, it is difficult to say at the moment. Due to the rapidly changing market, it is necessary to gain real-time insight into the raw material market, manufacturer quotations, and industry trends in order to roughly clarify the price of 3-methyl butyraldehyde in the current market.

I look at this formula, it is quite complicated. Let's talk about this chemical formula first, 4- (6-cyano-3-carbonyl) -6- (2-methoxy-2-methylethoxy) allyl-3-butyric acid.
When it comes to the safety of this substance, many considerations are required. The structure of this compound contains cyano, cyano, and it is also a highly toxic group. In chemical reactions and environments, it may release cyanide ions. Once it enters the organism, it can block the respiratory chain of cells, causing concern for human and animal life. If you are not careful, it will become a disaster.
Then talk about its toxicity. In addition to the toxicity of cyanyl groups, methoxy groups, methyl ethoxy groups and other groups may also affect organisms. In animal experiments, it may cause damage to the nervous system, liver, kidneys and other organs. And in the environment, it may be difficult to degrade, accumulate in water and soil, and cause harm to the ecology.
If you imitate the literary expression of "Tiangong Kaiwu", it is probably like this: this material has a complex structure, contains cyanyl groups, and is very toxic. Although the remaining groups also have potential harm, the poison of cyanyl groups bears the brunt of it. It is a serious hazard to personal safety and ecological environment. When using it, you must be cautious and strictly follow the procedures to prevent accidents. Dispose of the waste of this material also needs to be properly, so as not to pollute the environment and leave a disaster to future generations.