4-[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile

4 - [5 - (pyridin - 4 - yl) -4H - 1,2,4 - triazol - 3 - yl] pyridine - 2 - carbonitrile is an organic compound. This substance may have significant applications in the field of medicinal chemistry. Its structure contains pyridine and 1,2,4 - triazole groups. Such structures are often biologically active and are critical for drug development.
Looking at many drugs, the structures of pyridine and 1,2,4 - triazole often endow compounds with specific pharmacological properties. The pyridine ring has good stability and can participate in intermolecular interactions, such as the formation of hydrogen bonds with biological targets, π-π stacking, etc., which helps the compound to bind to specific receptors or enzymes to achieve specific physiological effects. The 1,2,4-triazole ring also has unique electronic properties and biological activities, which can regulate the lipophilic, acid-base and interaction mode of the compound with biological macromolecules.
In this compound, two pyridine rings are connected by the triazole ring, or form a special spatial structure to enhance affinity with biological targets. This structure may make it selective for specific disease-related targets, such as proteins and enzymes involved in cell signaling, inflammatory responses or tumor development. Therefore, 4 - [5 - (pyridin - 4 - yl) -4H - 1, 2, 4 - triazol - 3 - yl] pyridine - 2 - carbonitrile or innovative drug research and development, such as anti-tumor, anti-inflammatory, antiviral and other fields, provide direction for the research of lead compounds and help create new high-efficiency and low-toxicity drugs.

To prepare 4- [5- (pyridine-4-yl) -4H-1,2,4-triazole-3-yl] pyridine-2-formonitrile, the method of organic synthesis is often followed.
First take pyridine-4-formaldehyde and amino guanidine bicarbonate, and react with a suitable solvent, such as alcohol, in a heated reflux state. This step aims to obtain 5- (pyridine-4-yl) -4H-1,2,4-triazole-3-amine. The activity of pyridine-4-formaldehyde is quite good, and the amino group in the amino guanidine bicarbonate has nucleophilicity. When the two meet, they gradually form 5- (pyridine-4-yl) -4H-1,2,4-triazole-3-amine through various reactions such as nucleophilic addition and cyclization. Next, the resulting 5- (pyridine-4-yl) -4H-1,2,4-triazole-3-amine and 2-chloropyridine-4-formonitrile were obtained, and the reaction was heated and stirred in an organic solvent such as N, N-dimethylformamide with a base as a catalyst, such as potassium carbonate. The chlorine atom of 2-chloropyridine-4-formonitrile is active, and the amino nucleophilic attack of 5- (pyridine-4-yl) -4H-1,2,4-triazole-3-amine, the chlorine atom leaves, and through the nucleophilic substitution reaction, the final result is 4- [5- (pyridine-4-yl) -4H-1,2,4-triazole-3-yl] pyridine-2-formonitrile.
Or another way. First, 2-cyanopyridine is used as the starting material, through halogenation reaction, the pyridine ring is introduced into the halogen atom at a specific position, such as bromine atom, to prepare 2-cyano-4-bromine pyridine. Then 2-cyano-4-bromopyridine and 5- (pyridine-4-yl) -4H-1,2,4-triazole-3-boronic acid, with a palladium catalyst, such as tetra (triphenylphosphine) palladium, in an alkaline environment, such as sodium carbonate in an aqueous solution mixed with an organic solvent, through Suzuki coupling reaction, the target product can also be obtained 4- [5- (pyridine-4-yl) -4H-1,2,4-triazole-3-yl] pyridine-2-formonitrile. Each of these two methods has its own advantages and disadvantages, depending on the ease of availability of raw materials, reaction conditions, and the high or low yield.

4- [5- (pyridine-4-yl) -4H-1,2,4-triazole-3-yl] pyridine-2-formonitrile is an organic compound. Its physical and chemical properties are quite critical and have far-reaching implications for its applications in various fields.
Looking at its properties, this compound is mostly in solid form at room temperature and pressure. Its intermolecular forces make the molecules arranged in an orderly manner, resulting in a fixed shape and volume.
Melting point is also an important property. After determination, its melting point is in a specific temperature range. At this temperature, the solid and liquid states reach equilibrium, and the molecules gain enough energy to break free from the lattice binding and change their structure. The melting point is closely related to the intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. If the force is strong, the melting point is high.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and dichloromethane. Because the molecular structure contains polar parts and non-polar parts, it can be miscible with organic solvents with appropriate polarity according to the principle of similar compatibility. However, the solubility in water is poor. Due to its overall structure hydrophobic, the force between water molecules and compounds is weak.
Stability cannot be ignored either. Under normal conditions, the compound is structurally stable, and the chemical bonds within the molecule are strong, making it difficult to react spontaneously. However, in case of extreme conditions such as strong acids, strong bases or high temperatures, the chemical bonds may be affected, triggering decomposition or other chemical reactions. Strong acids and bases can provide protons or hydroxide ions to attack the active parts of the molecule; high temperature increases the kinetic energy of the molecule, intensifies the vibration of chemical bonds, and makes it easy to break.
The physicochemical properties of this compound provide an important basis for its synthesis, separation, purification and application, and are of great value in the fields of medicinal chemistry, materials science and other fields.

Today there is a product named 4- [5- (pyridine-4-yl) -4H-1,2,4-triazole-3-yl] pyridine-2-formonitrile, but its market price is not yet known. This substance may be a relatively uncommon chemical that is rarely circulated in ordinary stores, so its price is difficult to find.
If you want to know its exact price, you can check it carefully on various chemical trading platforms, such as Gade Chemical Network, Mobell Chemical, etc. Such platforms often gather many chemical products and their quotations, or you can get some. Or ask various chemical suppliers, who specialize in this industry, are familiar with the market, or can tell a detailed price. However, its price is also influenced by many factors, such as the cost of production, the situation of supply and demand, the quality of quality, and even changes in market conditions, which can make its price fluctuate. Therefore, in order to obtain an accurate price, it needs to be verified by many parties and compared in detail before it can be obtained.

Today, there are 4- [5- (pyridine-4-yl) -4H-1,2,4-triazole-3-yl] pyridine-2-formonitrile, and the manufacturers of this compound are difficult to find in detail. However, in today's chemical industry, many specialized pharmaceutical and chemical raw material manufacturers may be involved in the manufacture of this product.
In large-scale chemical production places, such as East China, North China and other chemical industries, there are many powerful enterprises. They are well-equipped and technically skilled, and often involved in the production of various fine chemicals. This compound may be among them.
There are also some companies that focus on the synthesis of heterocyclic compounds. With their profound research and development skills and professional production processes, they also have the ability to produce such compounds containing pyridine and triazole structures.
If you want to know the exact manufacturer, you need to check the chemical product directory, industry exhibition materials, or consult senior practitioners in the chemical industry to obtain more accurate information. There are many chemical production enterprises, and the product categories often change with market demand and research and development progress. Therefore, if you want to get the whole picture, you need to explore it in many ways, which cannot be ignored.