As a leading 4-(4-bromo-phenyl)-pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4- (4-bromo-phenyl) pyridine?
4 - (4 - bromophenyl) pyridine has a unique chemical structure. This compound is formed by linking a pyridine ring with a bromophenyl group. The pyridine ring is a nitrogen-containing hexamembered heterocycle, which has aromatic properties. The nitrogen atom on the ring endows it with a unique electron cloud distribution and chemical activity. The nitrogen atom has a pair of unshared electron pairs, which can participate in many chemical reactions, such as nucleophilic substitution, coordination and other reactions.
The 4 - bromophenyl group connected to it is the one whose 4 positions on the benzene ring are replaced by bromine atoms. The benzene ring is also aromatic, and the electron cloud is distributed delocalized and has stable properties. The introduction of bromine atoms can change the electron cloud density of the benzene ring due to the greater electronegativity of bro The bromine atom can be used as a leaving group to participate in nucleophilic substitution reactions, or to participate in coupling reactions under metal catalysis, which greatly expands the reaction path and application scope of this compound.
4- (4-bromophenyl) pyridine, the pyridine ring and the bromophenyl group are connected through carbon-carbon bonds, and the two parts interact with each other. The electronic effect of the phenyl group can affect the electron cloud density of the pyridine ring, and vice versa. This structural feature makes the compound show potential application value in organic synthesis, medicinal chemistry, materials science and other fields. For example, in organic synthesis, it can be used as a key intermediate to build more complex structures through different reactions; in the field of medicinal chemistry, due to the characteristics of pyridine rings and bromophenyl groups, or with specific biological activities, it can be used for drug development; in materials science, its unique electronic structure may endow materials with special optical and electrical properties.
What are the main physical properties of 4- (4-bromo-phenyl) pyridine?
4- (4-bromophenyl) pyridine is also an organic compound. Its physical properties are primarily related to its properties. At room temperature, it is mostly in the form of white to light yellow crystalline powder, just like finely crushed frost and snow, with a fine appearance.
As for the melting point, it is about 117-121 ° C. Just like a specific season, when ice and snow melt, this compound gradually melts from a solid state to a liquid state in this temperature range. The characteristics of this melting point can be used to identify and purify the compound.
Its solubility is also an important physical property. In common organic solvents, such as chloroform and dichloromethane, it can be dissolved quite well, just like fish getting water, and they blend seamlessly; however, in water, the solubility is very small, just like oil floating in water, and it is difficult to miscible. This difference in solubility is crucial in the separation and extraction steps of chemical experiments and industrial production.
and its boiling point, although the exact value or experimental conditions are slightly different, it is roughly in a higher temperature range. The boiling point is the critical temperature at which a substance converts from liquid to gaseous state. At this temperature, the intermolecular binding force is difficult to control, and the substance evaporates into gas, which is related to its stability and volatility in high temperature environments.
In addition, 4- (4-bromophenyl) pyridine has a certain density. Although its value is not widely known, in the accurate stoichiometry and preparation process, the consideration of density is also indispensable, which is related to the ratio of materials and the accuracy of the reaction.
All these physical properties are key factors in many fields such as organic synthesis and drug development, which affect the way and efficiency of its application.
In which chemical reactions is 4- (4-bromo-phenyl) pyridine commonly used?
4- (4-bromophenyl) pyridine is often used in many chemical reactions in organic synthesis. It is often used as a key building block when building complex organic molecular structures.
Geinpyridine ring is basic, and the bromine atom in 4- (4-bromophenyl) pyridine is quite active, which can initiate a variety of reactions. First, in nucleophilic substitution reactions, bromine atoms are easily replaced by nucleophiles. If nucleophiles such as alkoxides and amines react with it, novel C-O and C-N bonds can be formed, which is extremely useful in the synthesis of compounds containing specific functional groups.
Furthermore, in metal-catalyzed cross-coupling reactions, 4- (4-bromophenyl) pyridine is also a common substrate. For example, Suzuki coupling reaction, under the action of palladium catalyst, it can react with aryl boronic acid to realize aryl-aryl coupling. This is an important means to construct biaryl structures, and is widely used in the field of materials science, preparation of organic optoelectronic materials, etc.
In the carbon-hydrogen bond activation reaction catalyzed by transition metals, 4- (4-bromophenyl) pyridine can selectively activate the carbon-hydrogen bond at a specific location due to the guiding action of the pyridine ring, thereby achieving precise functionalization, opening up a new path for the synthesis of complex and specific organic compounds.
In addition, in pharmaceutical chemistry research, due to its unique structure, or as a structural unit of the lead compound, it is expected to develop new drugs through subsequent chemical modification. 4- (4-bromophenyl) pyridine is used in many chemical reactions in organic synthesis, materials science, drug research and development, etc., and is commonly used in scientific research and industrial production.
What are the synthesis methods of 4- (4-bromo-phenyl) pyridine?
The synthesis of 4- (4-bromophenyl) pyridine is an important topic in the field of organic synthesis. There are many common synthesis routes.
One is to use pyridine and brominated aromatics as raw materials and achieve coupling reactions catalyzed by transition metals. Among them, the palladium-catalyzed Buchwald-Hartwig coupling reaction is quite commonly used. Under suitable reaction conditions, the palladium catalyst works synergistically with the ligand to promote the formation of carbon-nitrogen bonds between the nitrogen atom of pyridine and the aryl carbon of brominated aromatics. If a suitable palladium source, such as palladium acetate, is selected with a specific ligand, such as tri-tert-butylphosphine, and the reaction is heated in a suitable solvent in the presence of a base, the target product can be obtained.
Second, it is prepared by the conversion of functional groups of pyridine derivatives. First, the pyridine is appropriately modified, and suitable functional groups are introduced, and then bromine atoms are introduced by halogenation reaction. For example, pyridine is first metallized to introduce metal groups at specific positions in the pyridine ring, and then reacted with bromine-containing reagents to introduce bromine atoms.
Third, the cyclization reaction is used to construct the target molecular structure. A chain compound containing appropriate functional groups is used as the starting material, and the pyridine ring is formed by intramolecular cyclization reaction, and bromophenyl is introduced at the same time. This process requires fine design of the structure of the starting material and reaction conditions to ensure the smooth progress of the cyclization reaction and the selective generation of the target product.
Each synthesis method has its own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected according to the comprehensive consideration of multiple factors such as the availability of raw materials, the ease of control of reaction conditions, and the yield and purity of the product.
What are the market application fields of 4- (4-bromo-phenyl) pyridine?
4- (4-bromophenyl) pyridine, an organic compound, is widely used in today's chemical, pharmaceutical, and materials fields.
In the chemical industry, it is often a key intermediate in the synthesis of many complex organic compounds. Through specific chemical reactions, it can be ingeniously converted into various chemicals with unique functions, such as high-performance dyes. With its special structure, it can endow dyes with excellent color stability and dyeing properties, and is widely used in textiles, printing and dyeing and other industries to make fabrics more vivid and lasting.
In the field of medicine, this compound also shows important value. The study found that its structure may have certain biological activity, which can be used as a lead compound for medical researchers to explore in depth. After structural modification and optimization, it is expected to develop new drugs for the treatment of various diseases, such as some difficult diseases, and bring new hope to human health.
In the field of materials, the effect of 4- (4-bromophenyl) pyridine should not be underestimated. In organic optoelectronic materials, it can be used as a key component in the construction of high-efficiency Light Emitting Diodes, solar cells and other devices. Because its structure can effectively regulate the electronic transport and optical properties of materials, it can significantly improve the performance and efficiency of these devices, promote technological progress in related fields, and facilitate the development and application of new energy-saving and high-efficiency optoelectronic materials.
In summary, 4- (4-bromophenyl) pyridine plays an indispensable role in many fields such as chemical industry, medicine, and materials, and plays a crucial role in promoting the development of various industries.
