4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4- (4-aminophenoxy) -N-methylpyridine-2-formamide, this is an organic compound. Its main use is often found in the field of medicinal chemistry.
In drug development, such compounds may have unique biological activities and can be used as lead compounds. After modification and optimization, they may become drugs for treating specific diseases. Because their structure contains specific functional groups, or they can interact with targets in vivo, such as binding to specific proteins, enzymes, etc., affecting physiological and biochemical processes in vivo.
In the field of organic synthesis, it can also be a key intermediate. With its structural properties, it can participate in many organic reactions, and through further reaction transformation, more complex organic molecular structures can be constructed, providing a foundation for the synthesis of new functional materials and the total synthesis of natural products. The characteristics and reactivity of this compound provide organic synthesis chemists with the possibility to explore new synthesis paths and methods and prepare compounds with special properties.

4- (4-aminophenoxy) -N-methylpyridine-2-formamide, this is an organic compound. Its chemical properties are unique and related to many chemical properties. Today, I will describe it in detail.
First, its physical properties are usually white to light yellow solids with a certain melting point. Due to the molecular structure containing groups such as benzene ring, pyridine ring and amide group, it has specific solubility in common organic solvents. For example, in polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it has good solubility, because these solvents and compound molecules can form hydrogen bonds or other intermolecular forces. In non-polar solvents such as n-hexane, the solubility is very small.
Discussing its chemical properties, the amide group is an important active site of the compound. The carbonyl group in the amide group has a certain electrophilicity and can react with nucleophiles. When encountering strong nucleophiles such as lithium aluminum hydride (LiAlH), the carbonyl group can be reduced to an alcoholic hydroxyl group, that is, the amide group can be converted into the corresponding amine group. And the amino group in the compound is nucleophilic and can participate in nucleophilic substitution reactions. For example, when reacting with halogenated hydrocarbons, the hydrogen on the amino group can be replaced by a hydrocarbon group to form an N-hydrocarbyl product.
And because it contains benzene rings and pyridine rings, both are aromatic. The benzene ring can undergo typical electrophilic substitution reactions, such as nitration reaction. Under the mixing of concentrated sulfuric acid and concentrated nitric acid, the hydrogen on the benzene ring can be replaced by nitro groups. Although the electron cloud density distribution of the pyridine ring is different from that of the benzene ring, the electrophilic substitution reaction can also occur. However, the reactivity is slightly lower than that of the benzene ring, and the reaction check point is mostly at the β-position of the pyridine ring.
In addition, the stability of the compound is also worth mentioning. Under normal conditions, the structure is relatively stable. However, under extreme conditions such as strong acid, strong base or high temperature, the molecular structure may change. If heated in a strong base solution for a long time, the amide group may hydrolyze to form corresponding carboxylic acids and amines.
In summary, 4- (4-aminophenoxy) -N-methylpyridine-2-formamide exhibits rich and diverse chemical properties due to its special molecular structure, and has potential application value in organic synthesis and other fields.

The synthesis method of 4- (4-aminophenoxy) -N-methylpyridine-2-formamide often involves several paths. First, it can be started from a compound containing the structure of pyridine-2-formamide and reacted with a reagent containing 4-aminophenoxy. In this process, appropriate reaction conditions need to be selected, such as adding a specific catalyst in a suitable solvent, controlling the temperature and reaction time, so that the two can be effectively combined to obtain the target product.
Furthermore, pyridine-2-carboxylic acid can also be used as a starting material to convert it into a more active derivative, such as acid chloride or acid anhydride. Subsequently, it is reacted with 4-aminophenol derivatives and methylamine derivatives. In this step, the regulation of reactivity and selectivity is crucial, and the reaction conditions need to be carefully selected to avoid unnecessary side reactions and improve the purity and yield of the product.
In addition, some synthesis methods use transition metal-catalyzed reactions. For example, palladium, copper and other metal catalysts catalyze the coupling reaction between pyridine-containing ring substrates and phenoxy and amino-containing substrates. This method can precisely construct the required carbon-nitrogen or carbon-oxygen bonds, but the reaction conditions are strict, and the amount of metal catalyst, the selection of ligands and the reaction environment need to be strictly controlled to ensure that the reaction is efficient and selective.
In short, the synthesis of 4- (4-aminophenoxy) -N-methylpyridine-2-formamide requires comprehensive consideration of various factors such as the availability of raw materials, the difficulty of reaction, the purity and yield of the product, and the appropriate synthesis method should be carefully selected in order to achieve a satisfactory synthesis effect.

There is a question today, what is the market price of 4- (4-aminophenoxy) -N-methylpyridine-2-formamide. Although this compound is not widely known, it may have specific uses in the field of chemical and pharmaceutical research and development.
It is not easy to know its price. The price often varies due to many reasons. The first one to bear the brunt is its purity. For high purity, the preparation is more difficult, the cost is also high, and the price is not cheap; for low purity, the preparation is slightly easier, and the price is slightly cheaper.
Furthermore, the supply and demand of the market also affect its price. If there are many people who need it, but there are few people who produce it, the price will increase; on the contrary, if the supply exceeds the demand, the price may drop.
In addition, the difference between manufacturers also makes the price different. Products from large factories, or due to state-of-the-art equipment and strict quality control, have higher prices; products from small factories, or due to cost control, have slightly lower prices.
Then I checked "Tiangong Kaiwu", but I didn't see this compound, because at the time of its publication, there was no such chemical product. To know its exact price today, when you consult chemical raw material suppliers, or check chemical product trading platforms, you can get a more accurate price.

4- (4-aminophenoxy) -N-methylpyridine-2-formamide is related to safety and toxicity, and it needs to be carefully studied.
In terms of safety, multiple considerations are required. During production and preparation, participating craftsmen must wear appropriate protective equipment, such as masks, gloves, etc., to protect against possible hazards. It can damage human health due to its percutaneous penetration or entry into the respiratory tract. During storage, it should be placed in a cool, dry and well-ventilated place to avoid fire and heat to avoid deterioration or danger.
As for toxicity, there is no detailed and conclusive research. However, compounds with similar analogical structures may have certain toxicity. Or cytotoxic, interfering with the normal metabolism and proliferation of cells, causing cell damage and even apoptosis. Or neurotoxic, affecting the function of the nervous system, causing dizziness, fatigue, insomnia and other symptoms. Or harmful to the reproductive system, interfering with the formation and development of germ cells.
Although there is no sufficient evidence of its toxicity, it should still be used with caution. After thorough experiments to explore its effects on organisms, its safe dose and potential harm should be clarified. Users should also follow strict procedures and must not be negligent to protect personal and environmental safety.