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What is the chemical structure of 4- (4- { (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) carbonyl} amino-2-fluorophenoxy) -2-pyridineformamide
To know the chemical structure of this substance, it is necessary to first understand the details of the groups involved. Many groups are mentioned here, such as "1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl", which is the key part.
From the above, it is inferred that this substance should be formed by connecting a specific number of groups with the arrangement. " 4- (4- { (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) carbonyl} amino-2-fluorophenoxy) - 2-indoleacetic acid ", this expression implies the connection order and bonding mode between the groups.
Its core structure or around the indole ring to expand, 1,5-dimethyl, 3-oxo, 2-benzyl and other groups are sequentially connected to the indole ring at specific positions. The "4-group" is connected to the carbonyl group, which in turn is connected to the amino group, and this amino group is associated with the fluorine-containing phenoxy group. Finally, this structure is partially connected to indoleacetic acid to form a complete chemical structure.
As a whole, the chemical structure of this compound is complex, composed of multiple different groups connected by specific chemical bonds. The properties and interactions of each group together determine the chemical properties and reactivity of this compound.
What is the main use of 4- (4- { (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) carbonyl} amino-2-fluorophenoxy) -2-pyridineformamide
4 - (4 - { (1.5 - dimethyl - 3 - oxide - 2 - phenyl - 2.3 - dihydro - 1H - pyrrole - 4 - yl) carbonyl} amino - 2 - fluorophenoxy) - 2 - pyrrolidinyl acetamide, its main use is in the field of medicine, with multiple effects.
This compound plays a key role in drug development. First, it may regulate the physiological process of the body by virtue of its effect on specific biological targets. For example, intervention in certain signaling pathways shows important value in disease treatment. In terms of neurological diseases, it can modulate neurotransmitter transmission and improve neurological function, such as for the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Second, in the field of anti-tumor, it may play an anti-cancer effect by inhibiting the proliferation of tumor cells and inducing their apoptosis. For a variety of tumors such as lung cancer and breast cancer, after in-depth research and clinical trials, it is expected to become a new type of anti-cancer drug. Third, in the treatment of cardiovascular diseases, it may have a positive impact on physiological processes such as vasodilation and blood pressure regulation, and help the treatment of hypertension, coronary heart disease and other diseases.
In modern pharmaceutical chemistry, such complex compounds endow them with diverse biological activities due to their unique chemical structures and properties. With the help of advanced technology, researchers have deeply explored the interaction mode between it and biological macromolecules, thereby optimizing the structure, improving the efficacy and reducing toxic and side effects. With the continuous deepening of research, the compound and its derivatives may bring more benefits to human health.
What is the safety of 4- (4- { (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) carbonyl} amino-2-fluorophenoxy) -2-pyridineformamide
The structure of this substance is quite complex. According to the structure, this is an organic compound containing a variety of specific groups. Its safety considerations need to be analyzed from multiple aspects.
From the perspective of group characteristics, groups such as 2-methoxy-3-oxo-2-phenylacetamide-2,3-dihydro-1H-indole-4-yl partially contain heteroatom functional groups such as nitrogen and oxygen, or make the compound have certain polarity and reactivity. The presence of methoxy groups may affect the lipid solubility of molecules and the distribution of electron clouds, or react with other substances such as nucleophilic substitution. The oxo, amide and other groups also have specific chemical activities, under certain conditions or participate in oxidation, hydrolysis and other processes.
From the perspective of stability, in such complex structures, if some chemical bonds are in a special electronic environment, or unstable under specific acid-base, temperature, and light conditions. For example, the structural part containing dihydroindole, its unsaturated bonds may undergo addition and oxidation reactions under oxidizing agents, high temperatures, etc., causing structural changes, or generating potentially toxic products.
From a toxicological point of view, although there is no direct toxicological data, the analogy contains similar group compounds, and some substances containing phenylacetamide structures may have certain neurotoxicity and reproductive toxicity. Because it contains multiple different groups, or after being absorbed by the skin, respiratory tract, and digestive tract, it undergoes metabolic transformation in the body, generates active metabolites, and interacts with biological macromolecules such as proteins and nucleic acids, interfering with normal physiological processes.
In summary, the compound may pose certain safety risks due to its complex structure and group characteristics. However, the exact safety needs to be determined through rigorous toxicological experiments, such as acute toxicity, chronic toxicity, genetic toxicity, teratogenicity, carcinogenicity, etc., and environmental safety assessments, and its degradability and bioaccumulation in different environmental media can be fully and accurately determined.
What is the production process of 4- (4- { (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) carbonyl} amino-2-fluorophenoxy) -2-pyridineformamide
To obtain this product, the method is as follows:
First view of this formula 4 dollars -\% 284 -\% 7B\% 281,5 - dimethyl - 3 - oxo - 2 - benzyl - 2,3 - dihydro - 1H - indole - 4 - group\% 29aldehyde group\% 7D hydroxy - 2 - chlorobenzoxy $, urgent, is for $1,5 - dimethyl - 3 - oxo - 2 - benzyl - 2,3 - dihydro - 1H - indole - 4 < Br >
First take an appropriate amount of a compound containing $1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl $, and add a specific reagent to a suitable reaction vessel to create an appropriate reaction environment to convert the aldehyde group according to the established reaction path. For example, a suitable reducing agent can be selected to reduce the aldehyde group to a hydroxyl group under mild conditions. This step requires precise control of the reaction temperature and time. The temperature should be maintained in a specific range, and the time should also be strictly controlled to ensure that the reaction is sufficient and not excessive.
For the $2-chlorobenzoxy $part, a suitable reaction substrate should be selected and introduced into the treated compound containing $1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl $through a specific chemical reaction. In this process, the choice of solvent is very critical. It is necessary to choose a solvent that can promote the smooth progress of the reaction according to the reaction characteristics, and it is necessary to pay attention to the side reactions that may occur during the reaction process, and adjust the reaction conditions in time to inhibit it.
Follow-up steps, when focusing on the stability and reactivity of the overall structure of 4 dollars -\% 284 -\% 7B\% 281,5 - dimethyl - 3 - oxo - 2 - benzyl - 2,3 - dihydro - 1H - indole - 4 - group\% 29aldehyde group\% 7D hydroxy - 2 - chlorobenzoxy $. Further modifications and adjustments may be required, such as protection and deprotection of certain groups, to achieve the efficient preparation of the target product 2 dollars - p-methoxyphenylacetic acid $. In the entire preparation process, each step of the reaction requires fine operation, strict control of the reaction conditions, and the use of modern analytical and testing methods, such as chromatography, spectroscopy, and other technologies, to monitor the reaction process and product purity in real time, in order to ensure the quality and yield of the final product.
What are the advantages of 4- (4- { (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) carbonyl} amino-2-fluorophenoxy) -2-pyridineformamide over other similar products?
4 - (4 - { (1,5 - dimethyl - 3 - oxo - 2 - benzyl - 2,3 - dihydro - 1H - indole - 4 - yl) carbonyl} amino - 2 - fluorophenoxy) - 2 - indolylacetic acid Compared with other similar products, its advantages are:
This compound has a unique structure, in which dimethyl, benzyl, indole and other groups cooperate with each other, giving it specific physical and chemical properties. In terms of biological activity, its unique structure may give it higher affinity and selectivity to specific targets in organisms. For example, the presence of 1,5-dimethyl and 2-benzyl groups may be able to optimize the binding mode of the molecule to the receptor and enhance its effect.
In terms of stability, the conjugated system formed by the oxygen group in the molecule and the surrounding atoms may improve its chemical stability and reduce the possibility of degradation under physiological environment or storage conditions, so as to maintain more durable activity in practical applications.
Furthermore, the introduction of 2-fluorophenoxy, the special electronic effect of fluorine atoms may change the electron cloud distribution of the whole molecule, affecting the balance of lipophilicity and hydrophilicity, which helps the compound to better penetrate the biofilm, improve bioavailability, and enable it to reach the site of action more effectively in the body.
In summary, 4- (4- { (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) carbonyl} amino-2-fluorophenoxy) -2 -indolylacetic acid exhibits advantages over other similar products in terms of biological activity, stability and bioavailability due to its unique molecular structure.