4-[(3-methylphenyl)amino]pyridine-3-sulfonamide

This is the chemical structure analysis of 4 - [ (3-methylphenyl) amino] pyridine-3-sulfonamide. Its structure includes a pyridine ring, and at the 3rd position of the pyridine ring, there is a sulfonamide group, that is, -SO 2O NH 2O group, which imparts specific chemical and physical properties to the compound, or affects its solubility and reactivity. At the 4th position of the pyridine ring, (3-methylphenyl) is connected by nitrogen atoms. This (3-methylphenyl) is composed of a benzene ring and a methyl group at the 3rd position. The introduction of methyl groups can change the spatial structure and electron cloud distribution of the molecule, which in turn affects the stability and lipophilicity of the molecule. In this way, the interaction of various parts together determines the unique chemical structure and properties of 4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide, which may lead to its specific applications and reactions in the fields of organic synthesis, medicinal chemistry, etc.

4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide is an organic compound. It has a wide range of uses and is often a key intermediate in the creation of new drugs in the field of medicinal chemistry. With its special chemical structure, medical researchers have carefully modified and modified it, hoping to develop drugs with excellent efficacy and mild side effects for the treatment of various diseases, such as anti-inflammation, anti-tumor, etc., which have potential application value.
In the field of materials science, this compound may be used to prepare materials with special properties. Due to the specific functional groups in its structure, it may endow materials with unique electrical, optical or mechanical properties, which can be applied to electronic devices, optical materials and many other aspects, and promote the innovation and development of related fields of technology.
Furthermore, in the field of organic synthetic chemistry, 4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide is also an important synthetic building block. Chemists can use various chemical reactions to skillfully splice it with other organic molecules to construct more complex and diverse organic compounds, expand the boundaries of organic synthesis, provide a rich material basis for the creation of new materials and new drugs, and promote the continuous development of organic chemistry.

4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide is a genus of organic compounds. Its physical properties are particularly important and are related to many characteristics of this substance. The details are as follows:
First of all, the melting point of this substance can be determined as a key basis for identification and purity judgment. However, the specific melting point value needs to be determined by precise experiments. Cover different experimental conditions, or cause slight differences. Generally speaking, the precise melting point can be obtained through rigorous experimental procedures, and this value is of great significance to the characterization of compounds.
Second words, boiling point, boiling point is also an important physical property. The boiling point of a compound is affected by many factors such as intermolecular forces and relative molecular weights. The characteristics of the intermolecular forces of 4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide determine its boiling point. To know the exact boiling point, scientific experiments must be used.
Solubility should not be ignored. In common organic solvents, its solubility may vary. In polar organic solvents, such as methanol, ethanol, or due to polar groups in the molecular structure, it shows some solubility. For non-polar organic solvents, such as n-hexane, benzene, etc., the solubility may be poor. This difference in solubility is due to the principle of "similarity and miscibility", that is, polar molecules are easily soluble in polar solvents, and non-polar molecules are easily soluble in non-polar solvents. < Br >
In terms of appearance properties, under normal circumstances, 4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide is mostly in solid form. Its color may be white to off-white, and its texture may be crystalline powder. This appearance feature can help to preliminarily identify this compound.
Density is also one of the physical properties. Although the exact density value needs to be determined by professional instruments, it is related to the degree of close packing of molecules. The regularity of molecular structure and the interaction between atoms all affect the density.
The above physical properties are of great value in the fields of chemical research, drug development, and materials science. It can help scientists understand the properties of compounds, thus laying the foundation for related applications.

To prepare 4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide, there are various methods. One method can be made of pyridine-3-sulfonyl chloride and 3-methylaniline as starting materials. First take pyridine-3-sulfonyl chloride, place it in a suitable reaction bottle, and dissolve it with an appropriate amount of inert solvent, such as dichloromethane, chloroform, etc. With stirring, slowly add 3-methylaniline dropwise, and at the same time add an appropriate amount of acid binding agent, such as triethylamine, to remove the acid generated by the reaction and promote the reaction to move to the right. After dripping, maintain a certain temperature, usually room temperature or slightly warm, when stirring the reaction for several times. After the reaction is completed, it is treated by conventional methods, such as pouring into water, separating the liquid, and the organic phase is washed with water, dried, evaporated to remove the solvent, and then purified by column chromatography to obtain the target product.
Another method can start from 3-methylaniline and protect its amino group first, such as using a protecting group such as tert-butoxycarbonyl (Boc). The protected product reacts with pyridine-3-sulfonyl chloride under conditions similar to the above. When the reaction is completed, the protecting group is removed, and the acidic conditions such as dilute hydrochloric acid and trifluoroacetic acid are used to obtain 4 - [ (3-methylphenyl) amino] pyridine-3 -sulfonamide. After further purification by recrystallization, the purity of the product can be higher.
Furthermore, pyridine-3-sulfonic acid can also be used as a starting material to convert it into a more active derivative, such as making it into an acid chloride, and then reacting with 3-methylaniline. For specific operations, pyridine-3-sulfonic acid can be obtained by reacting with thionyl chloride and other reagents to obtain pyridine-3-sulfonyl chloride, and then reacting with 3-methylaniline according to the previous method to obtain the product. The above methods have advantages and disadvantages. In actual preparation, according to the availability of raw materials, cost, product purity requirements and other factors, choose the best one.

4- [ (3-methylphenyl) amino] pyridine-3-sulfonamide is one of the chemical substances. However, the potential side effects of this substance are difficult to find in ancient books such as "Tiangong Kaiwu". Cover "Tiangong Kaiwu" for many things about process creations, rarely involved in the pharmacological side effects of such chemicals.
Today's modern medical research shows that such chemicals may have several potential side effects. First, in the digestive system, or cause gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, etc. The stomach is the root of human body transportation and transformation. If it is affected by such substances, it will cause various diseases. Second, it may affect liver function. The liver is responsible for dredging. If the drug action causes its function to be abnormal, or the transaminase is elevated, it will affect the flow of qi and blood throughout the body. Third, it may interfere with the immune system, making the body's ability to resist external evil weaker and prone to various diseases.
Although ancient books have not contained it, today's scientific research has gradually revealed the potential harm of such chemicals. When using drugs, the pros and cons should be carefully weighed to ensure human health.