As a leading 4-[3-MethoxyPropoxy]-3-Methyl-2-ChloromethylPyridineHcl supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4- [3-MethoxyPropoxy] -3-Methyl-2-ChloromethylPyridineHcl?
4 - [3-methoxypropoxy] - 3-methyl-2-chloromethylpyridine hydrochloride, this is an organic compound. It is widely used in the field of medicine, or as an intermediate for drug synthesis. Because the construction of drug molecules often depends on many specific structural fragments, the chemical structure of this compound may be ingeniously integrated into drug molecules through chemical reactions, giving drugs specific pharmacological activity.
It is also of great value in the field of pesticides. Or as a pesticide active ingredient, with its unique chemical properties, it acts on the nervous system and respiratory system of pests to achieve the effect of pest control; or as an important raw material for pesticide synthesis, helping to synthesize high-efficiency, low-toxicity and environmentally friendly pesticide products.
Furthermore, in the field of organic synthetic chemistry, it is often a key intermediate. Chemists can construct more complex and diverse organic molecular structures by performing various reactions on their functional groups, such as substitution reactions, addition reactions, etc., laying the foundation for the development of new materials and the preparation of fine chemicals. Because of its unique structure, it can introduce specific chemical groups and spatial configurations for subsequent reactions, expanding the possibility of organic synthesis.
What are the chemical properties of 4- [3-MethoxyPropoxy] -3-Methyl-2-ChloromethylPyridineHcl
4 - [3-methoxypropoxy] - 3-methyl-2-chloromethylpyridine hydrochloride is one of the organic compounds. It has unique chemical properties, and the following are described in detail.
First of all, the solubility of this compound is quite good in organic solvents, such as ethanol, dichloromethane, etc. Because there are polar groups in the molecule, such as methoxy, chloromethyl and pyridine rings, it can be well dissolved with organic solvents through intermolecular forces, such as van der Waals force, hydrogen bonds, etc.
Besides stability, under normal conditions, the compound is relatively stable. When exposed to strong acids, strong bases or high temperature environments, chemical reactions may occur. Although the pyridine ring is relatively stable, chloromethyl has high reactivity. Under the action of strong bases, nucleophilic substitution reactions are prone to occur, and chlorine atoms may be replaced by other nucleophilic reagents. At high temperatures, the chemical bonds in the molecule may also be broken and rearranged, resulting in changes in its chemical structure.
Its acidity, due to hydrochloride salts, has a certain degree of acidity. In aqueous solutions, hydrogen ions can be ionized, making the solution acidic. This acidity is used in some chemical reactions or as a catalyst to promote the reaction process.
In terms of reactivity, the dechloromethyl group can undergo nucleophilic substitution reaction, and the oxygen atom of the methoxy group has a lone pair of electrons, which can participate in the reaction as a nucleophilic reagent, or form a coordination bond with metal ions. The nitrogen atom on the pyridine ring also has certain reactivity, and under specific conditions, it can undergo protonation reaction or react with electrophilic reagents.
4- [3-methoxypropoxy] -3-methyl-2-chloromethylpyridine hydrochloride has rich and diverse chemical properties. It has important applications and research value in organic synthesis, medicinal chemistry and other fields due to its unique properties.
What is the production process of 4- [3-MethoxyPropoxy] -3-Methyl-2-ChloromethylPyridineHcl
The production process of 4 - [3-methoxypropoxy] - 3-methyl-2-chloromethylpyridine hydrochloride is particularly complicated and elegant.
The first to bear the brunt, the selection and purification of raw materials is crucial. Select high-purity pyridine derivatives, 3-methoxypropanol, chloromethylation reagents, etc. as starting materials. Pyridine derivatives need to be recrystallized many times to remove impurities and ensure that their purity reaches above 95 before they can proceed to the next step.
Then, the key reaction steps are carried out. First, the pyridine derivative is mixed with an appropriate amount of alkaline agent, and stirred evenly at a specific temperature to create an alkaline environment to facilitate subsequent reactions. Then 3-methoxypropanol is slowly added dropwise. During this process, the temperature should be strictly controlled between 30 and 35 degrees Celsius to prevent the growth of side reactions. After the dropwise addition is completed, the temperature is raised to 60 to 65 degrees Celsius, and the reaction continues for about five hours, so that the two are fully condensed to form an intermediate product.
After the intermediate product is formed, the temperature is cooled to 20 to 25 degrees Celsius, and the chloromethylation reagent is slowly added. After the addition, the reaction is continued at this temperature for about three hours to promote the successful introduction of chloromethyl into the molecular structure. This step of the reaction needs to be carried out in a nitrogen-protected atmosphere to prevent the oxidation of the product.
After the reaction is completed, the reaction solution is separated and purified. First, the organic solvent is extracted, the organic phase is stratified, and dried with anhydrous sodium sulfate to remove the moisture. Then, the organic solvent is recovered by reduced pressure distillation and the crude product is obtained. The crude product is separated by column chromatography, eluted with a suitable eluent, the target fraction is collected, and the solvent is removed by rotary evaporation to obtain a pure 4- [3-methoxypropoxy] -3-methyl-2-chloromethylpyridine.
Finally, the product is dissolved in an appropriate amount of alcohol solvent and passed into dry hydrogen chloride gas until the reaction solution reaches a saturated state. Let stand for crystallization, filter, wash the crystals with cold alcohol, vacuum dry, and finally obtain the finished product of 4- [3-methoxypropoxy] - 3-methyl-2-chloromethylpyridine hydrochloride. The whole production process, each step is closely linked, and the temperature, material ratio, reaction time and other factors need to be precisely controlled to obtain high-quality products.
4- [3-MethoxyPropoxy] -3-Methyl-2-ChloromethylPyridineHcl What are the precautions in storage and transportation
4 - [3-methoxypropoxy] - 3-methyl-2-chloromethylpyridine hydrochloride is an important compound in the field of fine chemicals. When storing and transporting, many matters must be paid attention to.
First, the storage should be selected in a dry, cool and well-ventilated place. This compound is prone to moisture and deterioration. If the storage environment humidity is too high, the moisture or chemical reactions such as hydrolysis will damage its quality and purity. Therefore, the warehouse should be equipped with a humidity control device to keep the relative humidity in a suitable range.
Second, temperature control is also critical. High temperature or cause the compound to decompose, volatilize or accelerate chemical reactions, affecting performance. It should be stored in an environment with stable temperature. Generally speaking, 5-25 ° C is more suitable, and it should be avoided from direct sunlight. Due to light or luminescent chemical reactions, its structure will be damaged.
Third, during transportation, ensure that the packaging is intact. The compound may be corrosive and irritating to a certain extent. If the packaging is damaged, it will leak or endanger the safety of transporters and pollute the environment. Packaging materials should be selected that can effectively protect and resist certain external shocks.
Fourth, it should be stored and transported separately from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with these substances or react violently, causing serious accidents such as fire and explosion.
Fifth, the storage and transportation places should be equipped with corresponding emergency treatment equipment and protective equipment. In the event of leakage and other accidents, the staff can take effective measures in a timely manner to reduce the harm.
Storage and transportation of 4- [3-methoxypropoxy] - 3-methyl-2-chloromethylpyridine hydrochloride must be operated in strict accordance with specifications, and all links must be treated with caution to ensure personnel safety and compound quality.
What is the market price range for 4- [3-MethoxyPropoxy] -3-Methyl-2-ChloromethylPyridineHcl
I am unable to determine the market price range of 4 - [3 - methoxypropoxy] - 3 - methyl - 2 - chloromethylpyridine hydrochloride. This compound may have applications in chemical industry, pharmaceutical research and development, etc., but its price is affected by many factors.
First, purity is the key factor. High purity is expensive due to the complex preparation process, and the price must be higher than that of low purity. If used in pharmaceutical synthesis, the purity requirements are strict, and the price will rise.
Second, the market supply and demand situation has a great impact. If the market demand is strong and the supply is limited, such as in the critical stage of new drug research and development, the demand for this compound will surge, and the price will rise; on the contrary, when the supply exceeds the demand, the price may fall.
Third, the preparation cost also affects the price. The cost of raw materials, production equipment input, labor costs, etc. are all included. Raw materials are scarce or the preparation process is cumbersome, the cost increases, and the price will also change accordingly.
Fourth, different suppliers have different pricing strategies. Large suppliers may be able to provide relatively favorable prices due to their economies of scale; small suppliers may have different prices due to different cost structures.
And the market price is in dynamic changes. Over time, technological progress, market structure changes, etc., will make its price fluctuate. To know the exact market price range, consult professional chemical product trading platforms, suppliers, or research relevant industry reports to obtain more accurate information.