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What are the chemical properties of 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-cyanoethyl) ester 5-methyl ester
3- (2,3-dihydroxybenzyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-hydroxyethyl) ester 5-methyl ester This is a class of organic compounds with a specific chemical structure. Its chemical properties contain many aspects.
From the perspective of the ester group in the structure, under alkaline conditions, hydrolysis is prone to occur. In case of strong bases such as sodium hydroxide, the ester bond will break and the corresponding alcohol and carboxylate will be formed. For example, when heated in an aqueous sodium hydroxide solution, the ester group of 3- (2-hydroxyethyl) ester will hydrolyze to produce 2-hydroxyethanol and carboxylate salts related to 3,5-dicarboxylic acids; the ester group hydrolysis of 5-methyl ester will generate methanol and corresponding carboxylate.
The part of the dihydropyridine ring in the structure has certain reductivity. Because it is in an unsaturated state, it is easily oxidized by oxidants and can react with some weak oxidants such as bromine water to fade the bromine water, and the pyridine ring will be converted into a more stable pyridine structure.
Furthermore, the hydroxyl group in the structure has the typical properties of alcohols. It can react with active metals such as sodium to generate hydrogen and corresponding sodium alcohol. At the same time, in the presence of acidic catalysts, esterification can occur with carboxylic acids, and more ester compounds can be derived.
The methyl group is relatively stable, but under specific strong oxidation conditions, such as long-term co-heating with acidic potassium permanganate solution, methyl groups may be oxidized to carboxyl groups.
The chemical properties of this compound are rich, providing many possibilities for research and application in organic synthesis and related fields.
What are the uses of 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-cyanoethyl) ester 5-methyl ester
Fu4 - (2,3 - dihydroxyphenyl) - 2,6 - dimethyl - 1,4 - dihydropyridine - 3,5 - dicarboxylic acid 3 - (2 - hydroxyethyl) ester 5 - methyl ester has a wide range of uses.
In the field of medicine, this compound is often a key component of cardiovascular drugs. The structural properties of 1,4 - dihydropyridine can effectively act on calcium ion channels on cell membranes. For example, it can precisely regulate calcium ion influx, which in turn affects myocardial contractility, heart rate and vascular smooth muscle tone. Therefore, it can be used to treat diseases such as hypertension, by dilating blood vessels and reducing peripheral vascular resistance, so as to achieve the purpose of lowering blood pressure. It is also commonly used in the treatment of angina pectoris, improving myocardial blood supply and relieving pain caused by myocardial ischemia.
In the field of organic synthesis, it also has important value. Because its molecules contain multiple active functional groups, such as hydroxyl groups, ester groups, etc., it can act as key intermediates. With the reactivity of these functional groups, organic compounds with more complex structures and more unique functions can be derived through various organic reactions such as esterification and substitution, providing rich raw materials and pathways for the development of organic synthesis chemistry.
In addition, in the early stages of drug development, this compound serves as a lead compound for the creation of new drugs. Scientists can improve its pharmacological activity and reduce toxic and side effects by means of structural modification and optimization based on its basic structure, and then develop new drugs with better efficacy and higher safety. All of these demonstrate the important uses of 4- (2,3-dihydroxyphenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-hydroxyethyl) ester 5-methyl ester in many fields.
What is the synthesis method of 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-cyanoethyl) ester 5-methyl ester
To prepare 4- (2,3-dihydroxybenzyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-hydroxyethyl) ester 5-methyl ester, the synthesis method is as follows:
First take an appropriate amount of 2,3-dihydroxybenzaldehyde, with a specific methyl-containing reagent, under suitable reaction conditions, such as in a specific solvent, at a certain temperature and under the action of a catalyst, carry out a condensation reaction to introduce 2,6-dimethyl groups to obtain intermediates containing corresponding structures.
Subsequently, the intermediate product is cyclized with the pyridine ring-containing precursor reagent in a basic environment or a specific catalytic system, and the 1,4-dihydropyridine ring structure is constructed to generate the intermediate product containing 4- (2,3-dihydroxybenzyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid structure.
Next, select a suitable esterification reagent, such as 2-hydroxy ethanol and methanol, and esterify with the carboxyl group of the above intermediate under the corresponding catalytic conditions. First, 2-hydroxyethanol is esterified with one of the carboxyl groups under acid catalysis or other suitable conditions to form a 3- (2-hydroxyethyl) ester; then methanol is esterified with another carboxyl group under similar or specific optimized conditions to obtain 5-methyl ester, thereby completing the synthesis of 4- (2,3-dihydroxybenzyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-hydroxyethyl) ester 5-methyl ester. Each step of the reaction requires strict control of reaction conditions, such as temperature, reaction time, reagent dosage, etc., to ensure the efficiency of the reaction and the purity of the product.
What is the market outlook for 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-cyanoethyl) ester 5-methyl ester?
The structure of this compound, 4- (2,3-dihydrobenzyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-hydroxyethyl) ester 5-methyl ester, has considerable market prospects.
This compound may have extraordinary applications in the field of medicine. The unique combination of groups in its structure makes the exploration of pharmacological activity full of possibilities. Dihydropyridine ring, benzyl, methyl, hydroxyethyl ester and methyl ester interact with each other, or can show affinity for specific biological targets, and are expected to be developed as drugs for the treatment of diseases such as cardiovascular diseases and nervous system diseases. Today, there are many patients with cardiovascular and nervous system diseases, and the market demand for related new drugs is strong. If it can be successfully developed, it will be able to occupy a certain market share.
In the chemical industry, this compound may be used as an intermediary for organic synthesis. Its complex and unique structure can be converted into other functional materials or fine chemicals by chemical modification. The chemical industry has a continuous demand for novel intermediates to meet the needs of product diversification, so it also has potential opportunities in the chemical raw material market.
Furthermore, with the progress of scientific research, the understanding of the structure-activity relationship of compounds has deepened. The structural characteristics of this compound may attract the attention of many scientific research teams, stimulate research enthusiasm, and thus promote the development of related academic research. The research results can feed back to the industry and further expand market applications.
Although facing challenges such as complex synthesis processes and cost control, with its potential value in the fields of medicine and chemical industry, with time, optimizing the production process and reducing costs, it will surely emerge in the market and have a bright future.
What is the safety of 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2-cyanoethyl) ester 5-methyl ester
"Tianwen Kaiwu" said: "The safety of Fu 4- (2,3-dioxybenzyl) -2,6-dimethyl-1,4-dioxycyclohexane-3,5-dicarboxylic acid 3- (2-oxyethyl) ester 5-methyl ester is related to many things. This compound has a complex structure and contains a variety of groups.
Among them, the characteristics of dioxybenzyl and dimethyl groups affect their stability and reactivity. The existence of dioxycyclohexane structure may make the molecule rigid to a certain extent, but it also affects its spatial arrangement.
In terms of chemical principles, such compounds may undergo reactions such as hydrolysis and oxidation under different environments. In case of acid-base environment, ester groups are easy to hydrolyze, causing structural changes, or generating products with different activities, which in turn affects safety. And contain oxidizing groups, in an oxidizing atmosphere, or be further oxidized, leading to a series of side reactions.
From the perspective of application scenarios, if used in the field of medicine, it is necessary to consider its impact on organisms. Such as whether it can pass through biological membranes, interact with biological macromolecules, etc. Because it contains a variety of special groups, or combine with proteins, nucleic acids, etc., it affects physiological functions. If used in the field of materials, stability and safety are related to material life and performance. < Br >
In summary, the safety of this compound needs to be investigated through many experiments, and its chemical properties, reaction characteristics, biological and material applications can be analyzed in multiple dimensions to clarify its safety picture. "