4-(1-Methyl-1H-Pyrazol-4-Yl)Pyridine

4- (1-methyl-1H-pyrazole-4-yl) pyridine is one of the organic compounds. It has a wide range of uses and plays an important role in many fields.
In the field of medicinal chemistry, this compound is often used as a key intermediate for the synthesis of biologically active drug molecules. Due to its specific chemical structure, it can interact with specific targets in organisms, thereby exhibiting potential pharmacological activity. In the development of drugs such as antibacterial, anti-inflammatory, and anti-tumor, 4- (1-methyl-1H-pyrazole-4-yl) pyridine may participate in the construction of the core skeleton of drug molecules. After modification and optimization, it can enhance the affinity and selectivity of drugs to targets and improve drug efficacy.
In the field of materials science, it also has good performance. It can be used as a building block for the preparation of functional materials, such as organic optoelectronic materials. With its unique electronic structure and optical properties, it can optimize the charge transport performance and luminous efficiency of materials in the development of organic Light Emitting Diode (OLED), organic solar cells and other devices, and promote the improvement of material properties and device innovation.
In addition, in the field of pesticide chemistry, this compound also has potential application value. Pesticide ingredients with insecticidal, bactericidal, and weeding properties may be derived, providing novel and effective means for agricultural pest control and promoting sustainable agricultural development.
In short, 4- (1-methyl-1H-pyrazole-4-yl) pyridine, with its unique chemical structure, has shown important uses in many fields such as medicine, materials, and pesticides. With the continuous progress of science and technology, its application prospects may be broader.

The method of synthesizing 4- (1-methyl-1H-pyrazole-4-yl) pyridine is an important matter in organic synthetic chemistry. This compound has a wide range of uses and is used in the fields of medicine, pesticides and materials science. The common ways to prepare this compound are as follows.
First, using pyridine as the starting material, a halogen atom is introduced at a specific position in the pyridine ring through a halogenation reaction, and then a metal-catalyzed coupling reaction is used to connect it with 1-methyl-1H-pyrazole-4-borate or its derivatives. This process requires careful selection of suitable metal catalysts, such as palladium, nickel, etc., and their ligands to ensure efficient and selective reactions. For example, using tetra (triphenylphosphine) palladium as a catalyst, under basic conditions, pyridine halide reacts with 1-methyl-1H-pyrazole-4-borate in an organic solvent to obtain the target product.
Second, it can also start from 1-methyl-1H-pyrazole, modify the pyrazole ring first, introduce a suitable functional group, and then react with pyridine derivatives. For example, 1-methyl-1H-pyrazole is converted into an intermediate containing active halogen atoms through acylation, halogenation and other steps, and then nucleophilic substitution reaction occurs with pyridine derivatives under alkali catalysis to generate 4- (1-methyl-1H-pyrazole-4-yl) pyridine.
Furthermore, the cyclization strategy is also a feasible method. By designing suitable linear precursors, it can undergo intramolecular cyclization reaction under specific conditions. For example, using chain compounds containing pyridine and pyrazole structural fragments as raw materials, with the help of suitable reagents and reaction conditions, the intracellular ring formation is promoted to construct the structure of the target product. This process requires fine regulation of reaction conditions, such as temperature, solvent, reactant ratio, etc., to ensure that the cyclization reaction proceeds smoothly and the yield is considerable.
There are various methods for synthesizing 4- (1-methyl-1H-pyrazole-4-yl) pyridine, and each method has its advantages and disadvantages. Researchers should carefully select the appropriate synthesis route according to actual needs, considering factors such as the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, etc.

4- (1-methyl-1H-pyrazole-4-yl) pyridine is one of the organic compounds. Its physical and chemical properties are worth exploring.
Looking at its physical properties, under normal circumstances, this substance is mostly in a solid state, with nearly colorless color or slightly different light color, depending on its purity and crystal form. The determination of its melting point can be one of the important indicators for identifying this substance. After many experimental investigations, it can be seen that its melting point roughly falls within a specific range. This range is in fine chemical and chemical analysis, and is the key to distinguish the purity of this substance. Furthermore, the boiling point is also an important item of its physical properties. The level of boiling point is related to the phase transition under different temperature conditions. This property is of great significance in the process of distillation and separation in chemical production.
In terms of chemical properties, in the molecular structure of 4- (1-methyl-1H-pyrazole-4-yl) pyridine, the pyridine ring coexists with the pyridine ring, giving it unique chemical activity. Pyridine ring is weakly basic and can react with acid substances to form corresponding salts. The substituent on the pyrazole ring, that is, 1-methyl, affects the electron cloud distribution and spatial structure of the whole molecule, thereby affecting its chemical activity. In the field of organic synthesis, this substance is often used as a key intermediate, which can introduce different functional groups through various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., to construct organic compounds with more complex structures. And because of its nitrogen-containing heterocyclic structure, it has also attracted much attention in the field of medicinal chemistry, or can be used as a lead compound to develop new drugs through structural modification and optimization.

4 - (1 - Methyl - 1H - Pyrazol - 4 - Yl) Pyridine is an organic compound, which is difficult to determine in the market price range. This is due to the interaction of many factors, resulting in uncertain price fluctuations.
First, the difficulty of production and preparation is deeply affected by the price. If the synthesis steps are complicated, special raw materials or harsh reaction conditions are required, the cost will rise, and the price will also rise. If the preparation of this compound requires multiple steps of reaction and precise control of the reaction conditions, the scarcity of raw materials is difficult to find, the cost is high, and the market price will be high.
Second, the amount of market demand also affects the price. If there is strong demand in the fields of medicine, materials science, etc., the supply exceeds the demand, and the price is easy to rise; on the contrary, the demand is sluggish, the supply exceeds the demand, and the price tends to fall.
Third, the fluctuation of raw material prices is closely related to the price of the compound. The price of raw materials is directly transmitted to the price of the finished product due to changes in market supply and demand, origin, season, etc.
Fourth, the scale of production cannot be ignored. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price may have downward space; in small-scale production, the unit cost is high, and the price is correspondingly higher.
Although it is difficult to determine the exact price range, it is possible to find relevant ways to obtain clues. Or consult professional chemical product suppliers, or consult the quotations of chemical product trading platforms, or refer to the prices of similar compounds in academic literature and industry reports for analogous speculation. However, the prices obtained are for reference only, and the actual prices vary according to specific transaction situations and market dynamics.

4- (1-methyl-1H-pyrazole-4-yl) pyridine is one of the organic compounds. The Quality Standards involved are crucial and relate to the purity, impurity limit, and physical and chemical properties of this compound.
The first discussion is on purity, which is the basis for measuring the quality of the compound. High purity 4- (1-methyl-1H-pyrazole-4-yl) pyridine, when it reaches a specific value, if measured by high performance liquid chromatography, its purity often needs to reach 98% or more to be qualified. The limit of impurities should not be underestimated. Among them, organic impurities, such as related isomers, degradation products, etc., need to be strictly controlled, and their limits are usually determined by specific detection methods to prevent impurities from affecting the properties and uses of compounds.
In terms of physical and chemical properties, the determination of melting point is quite critical. 4- (1-methyl-1H-pyrazole-4-yl) pyridine should have a specific melting point range, generally around a certain range, such as XX ° C - XX ° C, which can be accurately measured by melting point instrument. In addition, its solubility is also an important indicator. In common organic solvents, such as ethanol and dichloromethane, it should have certain solubility characteristics. This characteristic has a great impact on its application in synthesis, preparation and other processes.
Re-examine the moisture content of this compound, the moisture content of this compound needs to be maintained within a certain limit. Excessive moisture may damage its stability or affect the progress of related chemical reactions. Its moisture content is often measured by the Karl Fischer method, and the limit may be below XX%.
The content of heavy metals also needs to be strictly controlled. Due to the residue of heavy metals or the harm to the environment and organisms, the limit is extremely low by suitable methods, such as atomic absorption spectrometry, to ensure its safety.
In summary, the Quality Standard of 4- (1-methyl-1H-pyrazole-4-yl) pyridine is composed of multiple factors such as purity, impurity limit, physical and chemical properties, moisture and heavy metal content. All factors are strict to obtain high-quality products to meet the needs of all parties.