(3S)-1-benzylpyrrolidin-3-yl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)

This is the chemical structure of (3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1). Its chemical structure can be disassembled according to the name of each part.
(3S) -1-benzylpyrrolidine-3-ylmethyl, in which the pyrrolidine is a five-membered nitrogen-containing heterocycle, the 3-position is connected with 1-benzyl group in the (S) configuration, and the 3-position carbon is further connected with a methyl group.
(4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate moiety, 1,4-dihydropyridine is a six-membered nitrogen-containing heterocyclic ring, in which nitrogen and carbon at the 4th position are double bonds, the 4th position is connected with 3-nitrophenyl group in the (S) configuration, the 2nd and 6th positions are connected with methyl groups, and the 3rd and 5th positions are carboxylic acid ester structures. The whole compound is then salted in a 1:1 ratio with hydrochloric acid. This structure is cleverly combined with various groups such as nitrogen-containing heterocyclic, aryl group, ester group and salt-forming part. Each part interacts to coform this complex and specific chemical structure.

(3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1), this is an organic compound. Its physical properties are quite critical and related to many practical applications.
Looking at its appearance, it may be in the state of a crystalline powder at room temperature and pressure, with a white or off-white color. Due to the regular arrangement of molecular structures, the light reflection characteristics are so. In terms of solubility, it may exhibit certain solubility in organic solvents such as methanol and ethanol. Because there is a similar intermolecular force between the organic solute and the compound, which fits the principle of "similar miscibility". In water, its solubility may be limited. Due to the large proportion of hydrophobic groups in the molecule, it interacts weakly with water molecules.
Melting point is also an important physical property. It is speculated that the melting point of this compound may be within a specific range, which is determined by the intermolecular force and crystal structure. The stronger the intermolecular force, the greater the lattice energy, and the more energy required to destroy the crystal structure, the higher the melting point.
In addition, the stability of the compound also needs to be considered. In view of its containing nitro, ester groups and other functional groups, under certain conditions, chemical reactions may occur. If nitro is oxidizing, it will react with reducing agents or react; ester groups are catalyzed by acids or bases, or hydrolyzed.
In summary, the physical properties of (3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1) are complex and interrelated, and have far-reaching implications in the fields of organic synthesis and drug discovery.

To prepare (3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1), the method is as follows:
First take appropriate starting materials, such as pyrrolidine derivatives and dihydropyridine derivatives with specific configurations. In the reactor, dissolve the starting materials with a suitable organic solvent, such as dichloromethane or N, N-dimethylformamide, and stir well.
Then, according to the reaction process, add a suitable catalyst. This reaction needs to be carried out at a specific temperature, or at a low temperature to prevent side reactions from occurring; or at a heated reflux to promote sufficient reaction. For example, the reaction system can be maintained between 50 and 80 degrees Celsius, and the temperature can be controlled by an oil bath or a water bath. During the
reaction, closely monitor the reaction process, or use thin-layer chromatography to observe the spot change of the raw material and the product to know the reaction progress. When the reaction is basically completed, slightly cool the reaction liquid and proceed to post-treatment.
When post-treatment, or first wash the reaction liquid with a dilute acid or dilute alkali solution to remove impurities. Then extract the product with an organic solvent, collect the organic phase, and dry it with a desiccant such as anhydrous sodium sulfate. After filtering and removing the desiccant, the organic solvent is distilled under reduced pressure to obtain the crude product.
The crude product can be purified by column chromatography or recrystallization. During column chromatography, appropriate silica gel and eluent are selected to separate impurities and products; for recrystallization, a suitable solvent is selected, such as ethanol-water mixed solvent, heating to dissolve the crude product, cooling the crystallization, and filtering to obtain a pure (3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate.
Finally, the product is dissolved in a suitable organic solvent, hydrogen chloride gas is introduced or a suitable hydrochloride reagent is added. After the reaction, the target product (3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride can be obtained after treatment (1:1).

(3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1), a fine chemical substance with a wide range of uses.
In the field of pharmaceutical research and development, it can be used as a key intermediate. With its unique chemical structure, it can be converted into drug molecules with specific pharmacological activities through a series of delicate chemical reactions. For example, it can be used to synthesize drugs with potential therapeutic effects on cardiovascular diseases. By adjusting its molecular structure, it can act on specific targets in the cardiovascular system, such as affecting the activity of ion channels, and then regulating the rhythm of the heart and the tension of blood vessels, so as to achieve the purpose of treating related diseases.
In the field of organic synthetic chemistry, it is an extremely important building block. Because its structure contains multiple reactive functional groups, chemists can use it to construct more complex and diverse organic molecular structures. By ingeniously designing the reaction path, based on it, various reactions such as nucleophilic substitution and electrophilic addition can be carried out, expanding the carbon skeleton of organic molecules, providing the possibility for the synthesis of new organic materials or compounds with special properties.
Furthermore, in the study of medicinal chemistry, in-depth study of them is helpful to understand the structure-activity relationship of dihydropyridine compounds. By systematically changing the types, positions and quantities of their substituents, and observing their effects on biological activities and pharmacokinetic properties, it can lay a solid theoretical foundation for the rational design and development of more efficient and safe drugs.

(3S) -1-benzylpyrrolidine-3-ylmethyl (4S) -2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1), this is a special chemical substance, which should not be ignored due to its safety precautions.
First, caution is required in terms of chemical toxicity. This substance contains groups such as nitrophenyl, or has certain toxicity. If it is accidentally exposed, or absorbed through the skin, inhaled dust, or accidentally ingested into the human body, it may cause damage to health. If it damages the respiratory mucosa, causing cough, asthma and other discomfort; or irritates the skin, causing redness, swelling and itching; if taken by mistake, it is more likely to involve the digestive system, causing abdominal pain, vomiting and other diseases. Therefore, when operating, be sure to take protective measures, such as wearing suitable protective gloves, masks and goggles.
Second, storage conditions are also critical. Due to its nature or instability, it should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. If stored improperly, such as in a high temperature and humid environment, or mixed with other incompatible substances, or cause it to decompose, deteriorate, and even cause dangerous chemical reactions, such as combustion, explosion, etc.
Third, the use process should be standardized. During the experimental operation, it is necessary to strictly follow the established operating procedures and procedures. The dosage and reaction conditions are precisely controlled and cannot be changed at will. If chemical reactions are involved, the reaction mechanism and possible side reactions should be clearly understood to ensure safe operation and avoid accidents.
Fourth, waste disposal should not be ignored. After the experiment is completed, waste containing this substance must not be discarded at will. It should be collected and properly disposed of in accordance with relevant environmental protection regulations and laboratory regulations to prevent pollution to the environment and maintain ecological balance.