3-Pyridinecarboxylic acid, 5-chloro-6-hydroxy-

3-Pyridinecarboxylic acid, 5-chloro-6-hydroxyl, is a kind of organic compound. This compound has unique chemical properties. In its structure, the pyridine ring is the core, with a carboxyl group at the 3rd position, and the chlorine atom and the hydroxyl group at the 5th and 6th positions are respectively.
In terms of its physical properties, it may be solid at room temperature, because it contains polar groups, it may have a certain solubility in polar solvents. The presence of hydroxyl groups can cause the formation of hydrogen bonds between molecules, which affects its melting point, boiling point and other properties.
In terms of chemical properties, carboxyl groups are acidic and can neutralize with bases to form corresponding carboxylate. This is because carboxyl groups can ionize hydrogen ions. Chlorine atoms can participate in nucleophilic substitution reactions. Because chlorine atoms have certain electronegativity, the carbon atoms they connect have partial positive electricity and are vulnerable to attack by nucleophilic reagents. Hydroxyl groups are also active and can undergo esterification reactions, and under the action of catalysts with acids, ester compounds are formed. And the compound may have potential uses in materials science and other fields because it contains conjugated systems or has certain optical and electrical properties. At the same time, the nitrogen atoms on its pyridine ring can provide lone pairs of electrons, which can form coordination compounds with metal ions, etc., showing a variety of chemical behaviors, which may have application value in catalysis, medicine, etc.

3-Pyridinecarboxylic acid, 5-chloro-6-hydroxy, is widely used. In the field of medicine, it is often an important intermediate for drug synthesis. Because of its special chemical structure, it can be synthesized through a series of chemical reactions to obtain pharmaceutical ingredients with specific pharmacological activities, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs, which is of great significance to human health.
In the chemical industry, it is also significantly used. Or it can be used as a key raw material for organic synthesis, participating in the preparation of various functional organic compounds, used in the manufacture of dyes, pigments, fragrances and other fine chemicals. Its unique molecular structure endows the synthesized products with different properties and characteristics, enhancing the quality and application value of chemical products.
Furthermore, in the field of scientific research, it is used as a special chemical reagent for researchers to deeply explore the relationship between chemical reaction mechanism, molecular structure and properties. By participating in chemical reactions, it can gain insight into the mysteries of chemical processes, provide strong support for the development of chemical disciplines, and help the birth of new theories and methods to promote the continuous progress of the chemical field.

To prepare 5-chloro-6-hydroxy-3-pyridinecarboxylic acid, the following ancient method can be followed.
First take pyridine as the group, pyridine, with aromatic heterocyclic structure, chemical activity, is the main material for synthesis. Introduce a carboxyl group at the 3-position of pyridine. In this step, a suitable carboxylation reagent can be used, such as a specific halogenated acid and pyridine under the catalysis of a suitable base. The nucleophilic substitution reaction is carried out, and the reaction temperature, duration and material ratio are controlled to stabilize the carboxyl group at the 3-position.
Then, introduce a chlorine atom at the 5-position. Chlorine-containing reagents, such as chlorination agents, are often used to replace hydrogen at the 5-position with chlorine atoms under the condition of catalyst assistance. This catalyst needs to be carefully selected, considering its activity, selectivity and impact on the reaction system, and the reaction environment needs to be precisely controlled to prevent excessive chlorination or halogenation at other sites.
As for the introduction of 6-position hydroxyl groups, or the method of nucleophilic substitution can be used to react with pyridine derivatives with hydroxyl-containing nucleophiles. However, it should be noted in this step that due to the electron cloud distribution of the pyridine ring, the check point of nucleophilic substitution may have a selective direction, so a suitable activating group or protecting group needs to be used to introduce hydroxyl groups to the 6-position. Or a convertible group can be introduced into the 6-position first, and then chemically converted to form a hydroxyl group.
After each step of the reaction, a delicate separation and purification technique must be used to remove its impurities to obtain a pure product. For example, by distillation, recrystallization, column chromatography, etc., according to the different properties of the product and the impurities, the purity of the product is suitable for subsequent reactions. In this way, 5-chloro-6-hydroxy-3-pyridinecarboxylic acid can be prepared through a multi-step delicate reaction.

I look at your question, but I am inquiring about the price range of 3-pyridyl carboxylic acid, 5-chloro-6-hydroxyl group in the market. However, we do not have detailed price information, and it is difficult to tell you the exact price range.
These compounds may be useful in the fields of chemical raw materials, pharmaceutical intermediates, etc. The price is often influenced by many factors, the first being the cost of raw materials. If the raw materials required for preparation are scarce or expensive, the price of the finished product will also be affected by it.
Furthermore, the difficulty of the production process also affects the price. If the preparation requires complex technology, high-end equipment and fine operation, the production cost will increase greatly, which will cause the market price to rise.
The relationship between supply and demand in the market is also key. If there are many buyers, the demand is strong, and the supply is limited, the price will tend to rise; on the contrary, if the supply is sufficient and the demand is few, the price may drop.
In addition, different manufacturers and brands may have different prices due to their quality control and brand reputation.
If you want to know the exact price range, you can go to the chemical product trading platform and chemical suppliers for details, and you can also refer to industry reports and market survey data, so that relatively accurate price information may be obtained.

3-Pyridinecarboxylic acid, 5-chloro-6-hydroxy, its safety and risk are related to many aspects. If this substance is used in industrial processes, it should be considered in the operating environment and its impact on the craftsman. In a closed place, if it evaporates and disperses, inhalation can cause airway injuries, mild coughing, chest tightness, severe or lung disease.
Look at its contact with the skin, or there is a risk of irritation. If the skin is delicate, it may cause redness, swelling and itching. Accidentally entering the eyes can cause damage to the eyes, such as tingling, blurred vision, etc.
Talking about the risk, in terms of the environment, if this substance is not properly disposed of and flows into rivers, lakes and seas, it may cause disaster to aquatic organisms. Or cause aberration and death of fish, shellfish and other organisms, and then mess with the ecological balance.
And its chemical properties or activity, when stored, in case of improper conditions, such as high temperature, strong earthquake, or sudden chemical reaction, the risk of fire and explosion, endangering the safety of surrounding people, animals and buildings.
When using this substance, it is necessary to strictly abide by the procedures and prepare protective equipment, such as gas masks, protective gloves, goggles, etc. Storage should also be carefully placed in a cool, dry and ventilated place, and stored separately from other things to prevent accidents. Only in this way can the risk be reduced and the safety is guaranteed.