3-pyridinecarboxylic acid, 5-bromo-6-methoxy-, methyl ester

3-Pyridinecarboxylic acid, 5-bromo-6-methoxyl-, methyl ester, this substance has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate, assisting in the synthesis of many drugs. Due to the unique structure of this compound, it has specific chemical activities and reaction check points, and can be transformed into a variety of organic reactions to build complex and biologically active molecular structures. The synthesis path of many drugs for the treatment of specific diseases often involves the participation of this substance, either as a starting material or as an important reaction participant, which has a profound impact on the construction and activity shaping of drug molecules.
In the field of materials science, it also has applications. Due to its structural characteristics, it can be used as a building unit to participate in the preparation of functional materials. For example, in the synthesis of some organic optoelectronic materials, by rational design and modification, it can be introduced into the material skeleton, which can endow the material with unique optoelectronic properties, such as adjusting the emission wavelength, improving the charge transfer efficiency, etc., providing the possibility for the development of new optoelectronic materials.
In the field of fine chemicals, its importance cannot be underestimated. It can be used to prepare special chemicals and additives to give specific properties to products. For example, in the synthesis of some high-end coatings and plastic additives, its participation can improve key performance indicators such as product weathering resistance and stability, and enhance product quality and market competitiveness.

Methyl 5-bromo-6-methoxy-3-pyridinecarboxylate, in the form of white to pale yellow crystalline powder. Looking at its melting point, about [X] ° C, this value is quite important for identification and purity discrimination. In terms of solubility, it is slightly soluble in water, but can be better dissolved in common organic solvents such as dichloromethane, chloroform, acetone, etc. This property is of great significance in its extraction, separation and reaction operations. Under normal temperature and pressure, this substance is quite stable. In case of open flame and hot topic, it will be dangerous to burn. Therefore, when storing and using, it should be kept away from fire and heat sources. Furthermore, it is sensitive to light, and long-term light exposure may cause it to decompose. It should be stored in a cool, dry and dark place. Due to its specific chemical structure and activity, this substance is often a key intermediate for the synthesis of new drugs in the field of medicinal chemistry, and it has also emerged in the fields of materials science and plays a unique role.

Methyl 5-bromo-6-methoxy-3-pyridinecarboxylate, which has many chemical properties. Its appearance is mostly in the form of a crystalline powder, with a white or nearly white color, which is conducive to its observation and processing in many chemical operations.
When it comes to solubility, it is quite soluble in organic solvents such as methanol, ethanol, and dichloromethane. This property is of great significance in organic synthesis, allowing it to fully contact and react with other reagents in a homogeneous system. For example, in the subsequent treatment steps of some esterification reactions, its solubility in specific organic solvents is used to achieve separation from impurities.
In terms of stability, it is usually quite stable. However, when encountering strong oxidizing agents, strong acids and bases, the structure is easily damaged. For example, in a strongly acidic environment, the ester group may hydrolyze, causing the compound to transform into a corresponding acid; under strong alkaline conditions, not only the ester group hydrolysis, but also the pyridine ring may be affected, triggering reactions such as ring opening.
From the perspective of reactivity, its bromine atom is highly active and can participate in many nucleophilic substitution reactions. For example, when reacting with sodium alcohol, the bromine atom can be replaced by an alkoxy group to form a new compound containing a pyridine structure. This reaction is commonly used in the construction of complex organic molecular structures. The methoxy group at the 6-position has an influence on the electron cloud density distribution of the pyridine ring due to the electron supply effect, making the adjacent and para-positions of the pyridine ring more prone to electrophilic substitution.
In addition, the ester group is also a check point for reactivity, and can be hydrolyzed under the catalysis of acid or base to generate 5-bromo-6-methoxy-3-pyridinecarboxylic acid, which can be further used in the preparation of amides, acyl chloride and other derivatives, which are widely used in the field of organic synthesis.

The synthesis of 3-pyridinecarboxylic acid, 5-bromo-6-methoxyl-, and methyl ester is the key content of organic synthesis. To synthesize this substance, you can start from multiple ways.
First, pyridine is used as the initial raw material. The bromination reaction of pyridine is carried out first, and the bromine atom is introduced at the 5 position of pyridine. This process requires the selection of suitable brominating reagents and reaction conditions. Brominating reagents such as liquid bromine, N-bromosuccinimide (NBS), etc., reaction conditions such as temperature and solvent selection have a great influence on the yield and selectivity of the reaction. After the preparation of 5-bromopyridine is completed, the methoxylation reaction is carried out. 5-Bromo-6-methoxy pyridine can be obtained by reacting with reagents such as sodium methoxide and introducing methoxy groups at the 6th position. Finally, the product is combined with methanol and appropriate esterification reagents, such as concentrated sulfuric acid or dicyclohexylcarbodiimide (DCC), to achieve methylesterification of carboxyl groups, and the final product is 3-pyridinecarboxylic acid, 5-bromo-6-methoxyl-, methyl ester.
Second, it can also be started from other compounds containing pyridine structures. If the starting material already has some of the desired substituents, only the steps of functional group conversion and the introduction of remaining substituents are required to achieve the purpose of synthesis. For example, if there are methoxypyridine derivatives, bromine atoms can be introduced first, and then esterification reaction can be carried out.
During the synthesis process, the monitoring of each step of the reaction is also crucial. Thin-layer chromatography (TLC), nuclear magnetic resonance (NMR), mass spectrometry (MS) and other means can be used to monitor the reaction process in real time to confirm the structure and purity of the product, so as to adjust the reaction conditions in time to improve the synthesis efficiency and product quality.

I don't know the price range of 3-pyridinecarboxylic acid, 5-bromo-6-methoxyl-, methyl ester in the market. However, if you want to know the price of this product, you can ask for it from several places. First, ask chemical merchants, shops selling chemical raw materials in the city, or have this product, and ask for the price, you can get the approximate. Second, ask for it on the online platform of chemical product trading. There are many merchants listing the price on such platforms. After detailed investigation, you can also know the price. Third, visit the organization or website of professional chemical information, which often collects information on market prices, or can get a more accurate price range. I'm sorry I can't tell you the exact market price range of 3-pyridinecarboxylic acid, 5-bromo-6-methoxyl-, methyl ester. I hope this method will be helpful for you to ask for prices.