3 Pyridinecarboxylic Acid 2 5 Dichloro Methyl Ester
pyridine pyrrole pyrazine piperidine piperazine

3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester

    Specifications

    HS Code

    797218

    Chemical Formula C7H5Cl2NO2
    Molecular Weight 206.026
    Appearance Solid (likely white or off - white powder)
    Odor Typical organic ester - like odor (assumed)
    Solubility In Water Low (due to non - polar groups)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

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    General Information
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    Frequently Asked Questions

    As a leading 3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester
    3-Pyridinecarboxylic acid, 2,5-dichloro-, methyl ester, this is an organic compound. Its main uses are quite extensive. In the field of medicinal chemistry, it is often used as a key intermediate to assist in the synthesis of many drugs. For example, when developing certain drugs with specific physiological activities, it is like the cornerstone of building an elaborate drug molecule building, participating in complex synthesis steps, and contributing to the construction of molecular structures with precise pharmacological effects.
    In the field of materials science, it also plays an important role. It can be used as a raw material for the preparation of materials with special properties, and through specific chemical reactions, it can be transformed into materials with unique physical and chemical properties. For example, in the creation of new polymer materials, it can endow materials with unique electrical, optical or mechanical properties, so as to meet the needs of different fields for special materials.
    In organic synthetic chemistry, it is like an active "chemical dancer". With its unique chemical structure, it participates in various organic reactions, providing the possibility for the synthesis of more organic compounds with novel structures and specific functions. It promotes the continuous development of organic synthetic chemistry and expands the variety and application boundaries of organic compounds.
    What are the physical properties of 3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester
    3-Pyridinecarboxylic acid, 2,5-dichloro-, methyl ester, the physical properties of this substance are as follows:
    Its appearance is often white to off-white crystalline powder. In terms of melting point, it is in a specific temperature range, which helps to distinguish and purify the substance. In terms of solubility, it exhibits a specific dissolution behavior in organic solvents. For example, in common organic solvents such as ethanol and acetone, it has a certain solubility and can dissolve to form a uniform solution. This property is of great significance in the process of chemical synthesis and separation. It can realize the dissolution, extraction and recrystallization of the substance with the help of suitable solvents. In water, its solubility is relatively low, which also affects its application in different environments. In terms of density,
    has a specific value, which reflects the mass of the substance per unit volume, and is of guiding significance for container selection and material quantity calculation in chemical production, storage and transportation. In addition, its stability is good under general conditions, but it is necessary to avoid contact with strong oxidizing agents, strong acids, strong bases and other substances, because it may occur chemical reactions, change the original properties of the substance, and affect its use efficiency. Understanding these physical properties is essential for the correct use of this substance in chemical, pharmaceutical and other fields, and can help optimize production processes and improve product quality.
    3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester
    Methyl 2,5-dichloro-3-pyridinecarboxylate, this substance is colorless to light yellow liquid or crystalline, with a special odor. Its boiling point properties are that the melting point is between [X] ° C and [X] ° C, and the boiling point is [X] ° C under specific pressure. The substance is slightly soluble in water and has good solubility in most organic solvents such as ethanol, ether, and acetone.
    From the perspective of chemical activity, its pyridine ring and ester group give it unique reactivity. Pyridine cyclic nitrogen atoms have certain alkalinity and can react with acids to form corresponding salts; ester groups can be hydrolyzed under acid or base catalysis, and 2,5-dichloro-3-pyridinecarboxylic acid and methanol are generated during acid catalysis. Base-catalyzed hydrolysis is more thorough, and the products are 2,5-dichloro-3-pyridinecarboxylate and methanol. At the same time, because of its chlorine atoms, under appropriate conditions, it can participate in nucleophilic substitution reactions. The chlorine atoms are replaced by other nucleophiles, and a variety of pyridine derivatives are derived, which are used in the synthesis of fine chemicals such as medicine and pesticides.
    In terms of stability, it is relatively stable at room temperature and pressure, but in case of open flame, hot topic may cause combustion, and contact with strong oxidants will cause violent reactions, so it is necessary to avoid such substances when storing and using them. Store in a cool, well-ventilated place, away from fire and heat sources.
    What is the preparation method of 3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester
    To prepare methyl 2,5-dichloro-3-pyridinecarboxylate, the following method can be followed.
    Take 2,5-dichloro-3-pyridinecarboxylic acid as the starting material. This compound can be obtained by halogenation of specific pyridine derivatives. When halogenating, careful selection of halogenating reagents and reaction conditions is required to ensure the precise introduction of chlorine atoms at the 2,5 positions of the pyridine ring.
    After obtaining 2,5-dichloro-3-pyridinecarboxylic acid, mix it with methanol, add an appropriate amount of catalyst, and perform esterification reaction. Commonly used catalysts, such as concentrated sulfuric acid, p-toluenesulfonic acid, etc. During the reaction, it is necessary to pay attention to the control of temperature, usually under appropriate heating and reflux conditions, so that the reaction is sufficient. Although concentrated sulfuric acid has high catalytic activity, it is highly corrosive, so the operation must be careful; p-toluenesulfonic acid is relatively mild and can effectively catalyze this reaction.
    Another way is to protect the carboxyl group of picolinecarboxylic acid with a suitable protective group, then carry out halogenation reaction, and then deprotect the group and esterify it. This strategy can avoid the side reactions that may occur during the halogenation process, and improve the selectivity and yield of the reaction.
    After the reaction is completed, it is separated and purified to obtain a pure methyl 2,5-dichloro-3-pyridinecarboxylate. The commonly used methods for separation include extraction, distillation, column chromatography, etc. Extraction can take advantage of the difference in solubility between products and impurities in different solvents to separate products; distillation can achieve the separation of products and impurities according to the different boiling points; column chromatography can achieve the purpose of separation according to the difference in adsorption and distribution coefficients between products and impurities in the stationary phase and mobile phase.
    All of the above methods require the experimenter to weigh and choose according to the actual conditions, such as the availability of raw materials, the conditions of equipment, and the requirements for product purity. Only by careful operation can satisfactory results be obtained.
    3-pyridinecarboxylic acid, 2,5-dichloro-, methyl ester in the process of use
    3-Pyridinecarboxylic acid, 2,5-dichloro-, methyl ester. When using this substance, all precautions are very important.
    Bear the brunt of it, and safety protection must not be ignored. Because of its toxicity and irritation, it is necessary to wear suitable protective equipment, such as gloves, goggles and gas masks, to prevent contact with the skin, eyes and respiratory tract. If you accidentally touch it, you should immediately rinse it with plenty of water. In serious cases, you must seek medical attention urgently.
    Furthermore, storage should also be cautious. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent it from deteriorating or causing danger. At the same time, it should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed to avoid chemical reactions.
    During the operation, it is crucial to accurately control the reaction conditions. Factors such as temperature, pressure, reaction time, etc. will all affect the reaction effect. Be sure to strictly follow the established operating procedures, and must not change parameters without authorization. In addition, pay close attention to the reaction process, detect abnormal conditions in time and dispose of them properly.
    In addition, waste disposal cannot be ignored. It must not be discarded at will, and must be handled harmlessly by professional institutions in accordance with relevant regulations to avoid pollution to the environment.
    In summary, when using 3-pyridinecarboxylic acid, 2,5-dichloro-, and methyl ester, all of the above things should be treated with caution and must not be taken lightly to ensure the safety and smooth operation.