3-Pyridinecarboxamide, 2-chloro-6-(trifluoromethyl)-

"Tiangong Kaiwu" is a treasure of ancient science and technology in our country, and today it answers your questions in its classical Chinese genre.
The "chemical properties of 3-dimethylindole", 3- (triethyl) -6-deuterium-2-naphthol, of which 3-dimethylindole part has many unique chemical properties.
Methylindole, its benzene ring and pyrrole ring phase merger structure, giving it a specific reactivity. In electrophilic substitution reactions, the reaction check point of methylindole is mostly in pyrrole ring due to the electron-rich properties of pyrrole ring. In the case of halogenated reagents, the halogen atom preferentially replaces the hydrogen atom at the α-position of the pyrrole ring. And due to the presence of methyl groups, its electronic effect can affect the reaction activity and check point selectivity. Methyl groups are the power supply group, which can increase the electron cloud density of the benzene ring and the pyrrole ring, making the electrophilic substitution reaction more likely to occur.
Furthermore, in terms of acidity and alkalinity, methylindole is weakly basic due to the participation of lone pairs of electrons on the pyrrole ring nitrogen atom in the conjugated system. However, compared with typical fatty amines, its alkalinity is weaker. In the case of strong acids, it can protonate to form salts, and its structure and properties also change during this process.
In addition, the chemical properties of methy It can be oxidized by specific oxidants, and the structure of pyrrole ring or benzene ring changes to form corresponding oxidation products. Under the action of suitable reducing agents, the reduction of unsaturated bonds can be achieved, and the degree of unsaturation and spatial structure of molecules can be changed.
All these, 3-methylindole shows rich and diverse chemical properties in chemical reactions, and is of great significance in organic synthesis, pharmaceutical chemistry and other fields.

Tribromoethane, 3-methyl-6- (triethylmethyl) -2-pentyne-1-ol, this substance has a wide range of uses.
In the field of medicine, it is a key raw material for the synthesis of many special drugs. Through delicate chemical reactions, it can be converted into ingredients with unique therapeutic effects, such as targeted therapies for specific diseases. In the vast world of organic synthetic chemistry, it is like a cornerstone, providing a solid support for building complex organic molecular structures. With its unique chemical structure and activity, it can participate in a variety of reaction pathways to help synthesize organic compounds with novel structures and excellent properties, which are of immeasurable value in materials science, fine chemistry and other fields.
In the field of materials science, this material is used as a starting material and can be processed through a series of processes to produce polymer materials with unique properties. These materials either have excellent thermal stability or excellent mechanical properties, and are suitable for high-end fields such as aerospace, electronics and electrical appliances. For example, in the manufacture of aerospace equipment, the required materials need to maintain stable properties in extreme environments, and the materials synthesized with this material can meet such stringent requirements.
In the fine chemical industry, it plays an important role in the preparation of high-end fine chemicals. The production of fine chemicals such as special fragrances, high-performance coatings, and new catalysts is inseparable from its participation. These fine chemicals are widely used in every corner of daily life and industrial production, improving product quality and performance, and bringing many conveniences and improvements to people's lives and industrial development.

To prepare triethylpropionamide, the method is as follows:
First take an appropriate amount of diethyl malonate and place it in a clean reaction vessel. Using sodium alcohol as a catalyst, sodium alcohol can be added to the alcohol to obtain sodium metal until it is fully reacted. Under appropriate temperature and stirring conditions, bromoethane is slowly added dropwise. In this reaction, sodium alcohol can cause the methylene hydrogen of diethyl malonate to leave, forming a carbon negative ion. The carbon negative ion nucleophilic attacks the carbon-bromo bond of bromoethane, and a nucleophilic substitution reaction occurs to generate ethylmalonate diethyl ester.
Then, the obtained ethylmalonate diethyl ester is heated with an aqueous solution of sodium hydroxide. The purpose of this step is to promote the hydrolysis of the ester group to form sodium ethylmalonate. After the hydrolysis is completed, it is acidified with dilute sulfuric acid to obtain ethylmalonate.
Then the ethylmalonate is heated to decarboxylate. At this time, the carboxyl group will be removed in the form of carbon dioxide to form propionic acid.
Subsequently, propionic acid is used as a raw material and reacted with dichlorosulfoxide to convert propionic acid into propionic acid chloride. This reaction condition is relatively mild, and dichlorosulfoxide can better convert carboxyl groups to acyl chloride groups.
Finally, take propionic acid chloride and trimethylamine in a suitable solvent, such as dichloromethane, and react under low temperature The nitrogen atom of trimethylamine has lone pair electrons, which can carry out nucleophilic attack on the carbonyl carbon of propionyl chloride, and the chloride ions leave, and finally form triethylpropionamide.
The whole process needs to pay attention to the control of reaction temperature, reagent dosage and reaction time, in order to obtain higher yield of triethylpropionamide.

"Tiangong Kaiwu" states that the price of sulfur varies from time to time and place to place, and it is difficult to have a fixed number. However, according to past market conditions and various records, the price of aminopyridine made of triethylbenzene in the market is roughly regular.
Generally speaking, those with excellent sulfur quality are quite in short supply in the market, and the price is not cheap. The method of making aminopyridine with triethylbenzene as material is complicated and expensive, so the finished product is in the market, and the price is often high.
If it is in a prosperous commercial port, the city is easy to prosper, and there are many buyers, and when the supply is abundant, each catty is worth two or three dollars of silver. However, if the supply of goods is scarce, or in case of various changes, resulting in an imbalance between supply and demand, the price may rise sharply, and it is unknown whether it reaches five or six yuan per catty.
As for remote places, inconvenient transportation, business blockage, and poor circulation of their goods, the price may be unstable due to the high and low. Or due to difficult transshipment, the cost has increased greatly, and the price is higher than elsewhere; or due to weak demand, the price is slightly lower than that of Tongdu Dayi.
And the times change, and the years are different, which also affects its price. In a good year, everything goes well, all industries are prosperous, and the city is easy to prosper, and its price may rise steadily; in a disaster year, people's livelihood is difficult, all industries wither, and the market is weak in purchasing, its price may appear to fall.
Therefore, if you want to know the exact price of triethylbenzene aminopyridine in the market, you must carefully investigate the market conditions, supply, regional differences and various reasons at the time, and comprehensively, you can get a more accurate number.

"Tiangong Kaiwu" says: "Mercury is mercury. Its color is white, it flows well, it flies in case of fire, and there is no dust. The safety precautions related to di- to six (triethyl) -tri-methylindole are quite important."
Mercury is highly toxic, and it can hurt people when touched or smelled. When using triethylmethyl) indole, it is related to the safety of mercury, and the first thing to pay attention to is its volatility. Mercury is highly volatile into mercury vapor, which is colorless and odorless, but highly toxic. If you work in a confined space, mercury vapor is easy to accumulate, inhaled into the human body, damage the nervous system, kidneys, etc., causing tremors, insomnia, memory loss, proteinuria and other diseases. Therefore, the workplace must be well ventilated, and it is best to have a fume hood to disperse mercury vapor and reduce its concentration in the air.
Furthermore, avoid skin contact. Mercury touches the skin and can be absorbed through the skin. When handling mercury-related three (triethylmethyl) indoles, you need to wear protective clothing and gloves. If the skin is accidentally contaminated, you should immediately rinse with plenty of water and seek medical treatment.
In addition, mercury sprinkling treatment also needs to be cautious. If mercury spills from the container, do not touch it with your hands. Open doors and windows quickly for ventilation, and cover with sulfur powder at the same time. Because mercury and sulfur can form mercury sulfide, this is a relatively stable compound that can reduce its toxicity and volatility. After collecting mercury sulfide, dispose of it properly and do not discard it at will.
For storage, mercury-containing tris (triethylmethyl) indole and related items should be stored in a cool and ventilated place, away from fire and heat sources, and sealed to prevent mercury volatilization.
When operating, be careful not to spill or splash mercury-containing substances, and strictly follow the operating procedures. In this way, the operation can be kept safe and the danger of mercury damage can be avoided.